Insulin action
Maternal cigarette smoke exposure contributes to glucose intolerance and decreased brain insulin action in mice offspring independent of maternal diet.
... to insulin was evident in the hypothalamus. Interestingly, insulin receptors and signaling pathways are present in the hypothalamus, specifically in the arcuate nucleus, where NPY and POMC are predominantly ...
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Insulin Action in Peripheral Glucose Uptake - The Molecular Perspective Acção Periférica da Insulina na Captação de Glucose – a Perspectiva Molecular
... Although insulin presents different effects in different target-organs, one can consider that its major role in extra- hepatic tissues, such as skeletal muscle and adipose tissue, is to promote glucose ...of ...
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Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.
... impaired insulin secretion and insulin action, both of which precede and predict the onset of disease (Weyer et ...on insulin action, obesity is a major risk factor for the ...
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Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action.
... of insulin/IGF1-R in response to insulin is influenced by the number of receptors at the cell ...for insulin sensitivity and it has been shown that mutations in the InsR gene that impair the ...
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DYSFUNCTION INVOLVED IN THE DEREGULATION OF POSTPRANDIAL WHOLE-BODY INSULIN SENSITIVITY: A ROAD TO DIABETES AND ASSOCIATED PATHOLOGIES
... absolute insulin deficiency (Dotta and Eisenbarth, 1989; Muir et ...exogenous insulin for survival, and are prone to ketoacidosis, coma and ...in insulin action (insulin resistance) ...
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Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal.
... highly insulin resistant when compared with the lean subjects despite significant weight loss, improved glycaemic control and metabolic ...the insulin dose response profile to those observed in lean ...
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BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
... the insulin action mechanism, increasing the activity of its receptor, leading to translocation of the glucose transporters (GLUT4) to the plasmatic membrane of the skeletal muscles (Howlett and Bailey, ...
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Arq Bras Endocrinol Metab vol.58 número6
... Physiologically, when supplied to the cells, FFA is utili- zed to produce structural lipids and is disposed by mi- tochondrial oxidation (resulting in the production of ATP and heat), and/or by storage as ...
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Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance.
... of insulin, with a tendency toward a stronger effect of medium prepared from db/db than from Swiss mice ...2C). Insulin was still able to increase 473 Ser Akt phosphorylation in the presence of CM proteins ...
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Melatonin as metabolic regulator of sertoli cells
... 21 diabetes (T2D) show not only a decrease in the diurnal melatonin serum levels (Peschke, E. et al., 2006; Tutuncu, N. B. et al., 2005) but also of nocturnal melatonin serum levels, when compared to non-diabetic ...
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A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats
... and an angiotensin-converting enzyme in- hibitor attenuated the magnitude of the blood pressure elevation and improved insulin sen- sitivity in fructose-fed rats (28-30). Although several reports indicate fructose ...
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Engaging with participatory inquiry orientations
... of action research could also be explained by its ...of action research, Reason and Bradbury (2008) locate it with the work of Lewin (1946) and other social science scho- lars by the end of the Second World ...
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Secreção da insulina: efeito autócrino da insulina e modulação por ácidos graxos.
... The insulin receptor β-subunit, which con- tains an intrinsic tyrosine kinase activity, undergoes tyrosyl autophospho- rylation and is activated in response to insulin binding to the extracellular ...in ...
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Use of a small peptide fragment as an inhibitor of insulin fibrillation process: a study by high and low resolution spectroscopy.
... of insulin was predominantly characterized by intra residue and sequential NOEs between backbone proton and side chain proton resonances (Figure S1), clearly indicating that the peptide is highly flexible in ...
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Biphasic modulation of insulin receptor substrate-1 during goitrogenesis
... concerted action of TSH and insulin and/or insulin-like growth factor I (IGF-I), which function as co-mito- genic factors ...and insulin (IR) receptors in thyrocytes in culture and in human ...
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Recombinant human growth hormone and rosiglitazone for abdominal fat accumulation in HIV-infected patients with insulin resistance: a randomized, double-blind, placebo-controlled, factorial trial.
... Both study drugs have fallen out of favor since the design and conduct of our study. Growth hormone did not receive approval by the U.S. Food and Drug Administration (FDA) for the indication of reducing abdominal fat in ...
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Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats
... The rats were anesthetized with sodium thiopental (80 mg/kg body weight, intraperitoneally). The abdominal cavity was opened, the portal vein was exposed, and 6 mg of insulin was injected. Gastrocnemius muscle was ...
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Apneia obstrutiva do sono : marcadores de gravidade e de resposta à terapêutica
... Key Words: obstructive sleep apnea, OSAS, metabolic disease, cardiovascular disease, biomarkers, glucose, insulin, insulin resistance, HOMA-IR, HbA1c, cholesterol, HDL, LDL, triglyceride[r] ...
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Insulin autoimmune syndrome in an occidental woman: a case report and literature review
... Laboratory results are presented in Table 1. Initial blood glucose (8-hour fast), serum insulin, and C-peptide levels were 91 mg/dL (reference range: 65 – 99 mg/dL), 620.9 µIU/mL (reference range: 2.6 – 24.9 ...
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Análise da expressão de proteínas da via de sinalização de insulina em próstata de ratos tratados com dexametasona
... investigated the insulin signaling pathway and epithelial cell proliferation in the rat prostate in a.. model of decreased insulin sensitivity induced by dexamethasone.[r] ...
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