Lead compounds
Computational development of rubromycin-based lead compounds for HIV-1 reverse transcriptase inhibition
... of compounds containing naphtoquinone and 8-hydroxyisocoumarin moieties (Brasholz et ...these lead compounds has long been prevented due to the difficulty of their laboratory synthesis, but several ...
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Medicinal chemistry of N-acylhydrazones: novel lead-compounds of analgesic, antiinflammatory and antithrombotic drugs.
... NOVEL LEAD-COMPOUNDS OF ANALGESIC, ANTIINFLAMMATORY AND ANTITHROMBOTIC ...isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new ...
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3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compounds.
... Schistosomiasis is a major tropical endemic disease in develop- ing countries. It is estimated that 779 million people in 76 countries and territories are at risk of this disease, which results in approximately 28,000 ...
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The Role of Spongia sp. in the Discovery of Marine Lead Compounds
... substituted rings A and B. Confirmation of these rings stereochemistry was obtained from pyridine-induced solvent shifts. For 76 the NMR data indicated the presence of a carbonyl group, a tetrasubstituted double bond, ...
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Assessment of the In Vivo Genotoxicity of New Lead Compounds to Treat Sickle Cell Disease
... The compounds 1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl nitrate (C1), (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl nitrate (C2), 3-(1,3-dioxo-1,3-dihydro-2H- isoindol-2-yl)benzyl nitrate (C3), ...The ...
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REPOSITORIO INSTITUCIONAL DA UFOP: Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from Tipifarnib.
... would lead to undesirable side effects such as bone marrow suppression, we designed and synthesized analogs of tipifarnib that avoided PFT-inhibitory activity while retaining CYP51 ...
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J. Braz. Chem. Soc. vol.26 número12
... Several lead compounds may thus be found in the tricyclic cationic class which, due to the large number of starting points for photosensitising drug discovery, is the subject of the present ...cationic ...
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Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods.
... flavonoid compounds exist in various vegetables, fruits, and other ...these compounds reportedly might reduce the risk of developing lung cancer ...flavonoid compounds that can bind with and affect ...
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J. Braz. Chem. Soc. vol.25 número10
... and lead compounds from the Brazilian flora, this study evaluated the leishmanicidal activity of Brozimum glaziovii (Moraceae) and used high-resolution gas chromatography (HRGC) and gas chromatography- mass ...
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High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers.
... below has the potential to be applied to a wide variety of cell types, including primary cells, as Lin et al [18] have shown only around 5% of toxic compounds demonstrate tissue specific cytotoxicity in in vitro ...
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Prices lead earnings no Brasil?.
... Contudo, as premissas “i” e “ii” são pouco realistas e contrariam as implicações da eficiência de mercado, hipó- tese subjacente assumida pela pesquisa contábil em merca- do de capitais. Em um mercado eficiente, o preço ...
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Analysis of Phenolic, Sulfur and Volatiles Aroma Compounds in Wines of Fogo Island - Cape Verde
... sulfur compounds are parts of a large group of compounds which affect the sensorial quality of the ...these compounds are very low, producing strong olfactory impact in wines even if the ...
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Braz. J. Phys. vol.34 número2B
... semicondutor compounds have been investigated by several groups in the last ...the lead salts has demon- strated to be useful for infrared optoelectronic applications, in particular for the fabrication of ...
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Honey volatiles as a fingerprint for botanical origin: a review on their occurrence on monofloral honeys
... Eucalyptus honey, with an intense and moderately persistent flavour, tasting of soft caramel and mushrooms [83], shows several classes of volatile compounds [62,78,79,84,95,96], some of them common between honeys ...
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Keywords Edible flowers · Volatile compounds · Sensory analysis · Bioactive compounds
... Table 2 shows the total reducing capacity (TRC), hydrolys- able tannins, total flavonoids, and monomeric anthocyanins contents determined in the five studied edible flowers. Sig- nificant differences among them (p < ...
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Braz. J. Pharm. Sci. vol.53 número1
... synthesized compounds 3-23 was evaluated against ...test compounds and for the reference drug luconazole are presented in Table ...I. Compounds 3-9 were found to be inactive against ...while ...
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J. Braz. Chem. Soc. vol.9 número3
... 98 compounds presented are those which gave significant peaks in gas chromatograms, together with minor compo- nents of possible odour significance, ...e.g. compounds which were described as having a ...
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Proposta para a gestão de estoques de novos produtos: solução do modelo (Q,r) para a distribuição uniforme da demanda e do lead-time de suprimento.
... Esse exemplo numérico ilustra não apenas como a gestãodeestoquesdeumnovoprodutopodeserplaneja- dapormeiodosresultadosdesenvolvidos,mastambém ...
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Ubiquity of Lead in Our Lives–Lead in Food
... for lead and Lead poisoning is entirely preventable. Lead exposure has resulted in ...Childhood lead exposure is about 600,000 new children with intellectual ...to lead, particularly in ...
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DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult and pediatric high-grade gliomas
... of lead anticancer agents for further analysis ...the lead agents were potent inhibitors of topoisomerase II and, consistent with this cellular target, examined the HIF-1 a and p53 signaling networks in key ...
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