protein kinase
AMP-activated protein kinase as a target for pathogens: Friends or foes?
... the protein kinase B (PKB)/ (AKT) pathway to phosphorylate AMPK at Ser485, resulting in the inhibition of AMPK ...membrane protein 1 (LMP1) oncogenic protein inhibits the activity of AMPK ...
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Identification of Casein Kinase 1, Casein Kinase 2, and cAMP- dependent Protein Kinase-like Activities in Trypanosoma evansi
... this protein kinase was responsible for the phosphorylation of tubulin in ...Additionally, kinase assays were also carried out in the presence of exogenously added casein for ...
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Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.
... and protein kinase activity by small molecules does not always directly correlate is also interesting and has potential implications for the use of PI 3-K inhibitors in the clinic, as it may explain the ...
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Determinants of cell-to-cell variability in protein kinase signaling.
... signaling protein concentrations give rise to cell-to-cell variability in protein kinase signaling using analytical theory and numerical ...Minimal kinase cascades with gradual dose-response ...
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Analysis of the chloroplast protein kinase Stt7 during state transitions.
... Stt7 protein kinase was associated with a large complex that partly overlaps with the high molecular weight fractions of PSI and the cytochrome b 6 f complex but not with PSII (Figure ...
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Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.
... lipid kinase activity of PI3K, we were unable to observe any detectable activation of lipid kinase activity in response to 1 pM cytokine (Figure 4) despite the ability of these concentrations of cytokine to ...
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Genome-wide identification and analysis of expression profiles of maize mitogen-activated protein kinase kinase kinase.
... Genome-wide Identification of MAPKKK Family in Maize Availability of complete maize genome sequences has made it possible for the first time to identify all the MAPKKK family members in this plant species. BLAST searches ...
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Redox regulation of the AMP-activated protein kinase.
... AMP-activated protein kinase (AMPK), a heterotrimeric complex comprised of a catalytic subunit a and two regulatory subunits, b and c, is an evolutionarily conserved serine/threonine protein ...
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DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
... Tumor cells might resist therapy with ionizing radiation (IR) by non-homologous end-joining (NHEJ) of IR-induced double-strand breaks. One of the key players in NHEJ is DNA-depen- dent protein kinase ...
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Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.
... Protein kinase signaling cascades control most aspects of cellular ...signaling protein kinases are the targets of most available ...of protein kinases for their ability to increase Drosophila ...
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DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.
... Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells. AID ...
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Rational design of protein kinase inhibitors
... of protein kinase in- ...of protein kinase inhibitors is based on the fine understan- ding of structural mechanisms of specific binding of low molecular weight organic compounds with these ...
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Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor
... Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, plays an important role in the pathogenesis of atrial fibrillation; however, the upstream regulation of MIF in atrial myocytes remains unclear. In the ...
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Protein kinase A binds and activates heat shock factor 1.
... Our experiments therefore suggest a novel mechanism in the activation of hsp70 after stress, involving HSF1 association with PKAca and phosphorylation by this kinase at a novel site (serine 320) (Fig. 1). These ...
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The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors.
... G protein coupled ...one protein kinase AKT (Protein kinase B) (while there are three in human and two in sea urchin) and one p70S6K (2 in human; 1 in sea ...tyrosine kinase ...
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Rev. Bras. Hematol. Hemoter. vol.37 número5
... (RAS)/Mitogen-activated protein kinases (MAPK) and phos- phoinositide 3-kinase (PI3K)/protein kinase B (PKB, aka Akt) pathways, which results in an increased expression of mitotic proteins, ...
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Auxinic herbicides, mechanisms of action, and weed resistance: A look into recent
... Death of most plant tissues treated with 2,4-D is caused by the accumulation of abscisic acid (ABA) and ethylene inducing oxidative stress induced by high ROS production (Grossmann, 2007; 2010). These free radicals are ...
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Identifying protein phosphorylation sites with kinase substrate specificity on human viruses.
... a protein greatly affect the specificity of a particular kinase ...this, kinase- specific phosphorylation site predictors have been ...dependent protein kinase, protein ...
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Comparative transcriptome analysis of two rice varieties in response to rice stripe virus and small brown planthoppers during early interaction.
... receptor-like protein kinase and pathogenesis-related protein did not increase, rather these genes were down-regulated significantly after infesting rice with SBPHs that carried RSV; Thus HR was not ...
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Revisiting the roles of VHRDUSP3 phosphatase in human diseases
... a protein tyrosine phosphatase enzyme that regulates the phosphorylation of the mitogen-activated protein kinase signaling pathway, a central mediator of a diver- sity of biological ...
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