[PDF] Top 20 Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
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Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
... mode of sertraline was attributed to the decreased cyto- plasmic ATP levels and oxygen consumption rate in pro- mastigotes, suggesting an apoptosis-like death in treated ... See full document
12
In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
... series of bis-2,5-(4-guanidinophenyl) thiophenes that had antichagasic properties, but lacked cytotoxic ef- ...active of these compounds had an IC 50 of ...degree of anti-amastigote ... See full document
6
The efficacy of 2-nitrovinylfuran derivatives against Leishmania in vitro and in vivo
... advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and ...activity of ... See full document
8
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of a Novel Nitro-derivative
... by Trypanosoma cruzi (WHO 1993), the causative agent of this ...made in the control of vectorial and transfusion transmission of the disease, through spraying programs to ... See full document
5
Ruthenium complex with benznidazole and nitric oxide as a new candidate for the treatment of chagas disease.
... synthesis and evaluation of ruthenium complexes as antiparasitic ...series of ruthenium complexes have furnished improvements, as they show lower toxicity and higher hydrosolubility than the ... See full document
7
In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection.
... modifications of the chemical structure of these synthetic compounds can lead to a higher selectivity and ...efficacy. In DB766, the 2 core structure-benzene rings of DB75 were ... See full document
8
Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi
... endemic in 21 countries of Latin ...worldwide and ap- proximately 10 million others are at risk of infection, with 14,000 new cases and 12,000 deaths occurring each year ...(2) ... See full document
7
Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi
... rangeli and T. cruzi differently to ...use of this class of drugs as broad-spectrum ...differences in susceptibility towards DNA topoisomerase inhibitors between American and ... See full document
5
In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)
... Leishmaniasis and trypanosomiasis are globally widespread parasitic diseases which have been responsible for high mortality ...nephrotoxic and cardiotoxic, adherence to therapy has been ...effective ... See full document
9
An in silico Study of Benzophenone Derivatives as Potential Non-Competitive Inhibitors of Trypanosoma cruzi and Leishmania Amazonensis Cysteine Proteinases
... mechanism of interaction of Llacys1 and cruzain with benzophenones by homology modelling, docking and molecular dynamics ...family of cysteine proteases and present a high degree ... See full document
13
Antimicrobial activity of Tachyplesin 1 against Burkholderia pseudomallei: an in vitro and in silico approach
... preliminary study, the MIC and MBC values of TP1 were determined to be higher than LL-37 and ...values of TP1 towards ...isolates in order to exhibit the inhibition ...assist ... See full document
29
In vitro effects of citral on Trypanosoma cruzi metacyclogenesis
... depolarization of the mitochondrial mem- branes and permeabilization of the outer and inner mito- chondrial membranes, which leads to cell death by apopto- sis and necrosis (Yoon et ... See full document
7
A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI
... biochemical and genetic diversity of Trypanosoma cruzi strains has long been recogn- ised, along with their eco-epidemiological complex- ity, which has been reviewed extensively elsewhere ... See full document
4
Estudos funcionais de genes envolvidos na manutenção da estabilidade genômica : caracterização de gene hHC1 humano e da DNA polimerqase -PAK de Trypanosoma cruzi.
... envolvidos na manutenção da estabilidade do genoma. O entendimento sobre os processos de replicação e reparo do DNA é fundamental para entendermos a variabilidade genética em T. cruzi , assim como, para o estudo ... See full document
4
Determination Of Longevity Of Teeth In Buckets Of Loading Equipment In Coal Mines - A Case Study
... The study took into account the effects of machine scale, wear surface structure of the rolls, grinding pressures and rolls speed, gap settings, feed size distribution and moisture ... See full document
11
An Advancement To The Security Level Through Galois Field In The Existing Password Based Technique Of Hiding Classified Information In Images
... number of ASCII ...Stego-images of size 256 x 256 using the proposed techniques, calculated for 1500 ...embedded in a 256 x 256 pixel image. This shows that, 12.5% of the image pixels are used ... See full document
6
J. Braz. Chem. Soc. vol.20 número4
... for in vitro activity against chloroquine-sensitive Plasmodium falciparum 3D7, Trypanosoma brucei rhodesiense STIB900 and Leishmania donovani ...L82. An assay with KB cells was ... See full document
16
MATERIAL AND METHODS Sample collection
... r.p.m. and 28°C for five days. The fungal growth of the pre-inoculum flasks was transferred to 250 mL Erlenmeyer flasks containing 100 mL ...filtration and the filtrate was extracted with ethyl ... See full document
11
Antiprotozoal activity of quinonemethide triterpenes from Maytenus ilicifolia (Celastraceae)
... 1 and 2, respectively, we obtained SIs for ...243.65 and 46.61 for 1 and 193.63 and 23.85 for 2, as shown in Table ...T. cruzi epimastigotes the SIs were 85 for 1 and ... See full document
10
Escherichia coli, which are two of the pathogens
... 0.1ml of strains suspended in this organic matter instead of ...out in triplicate, using a newly prepared dilution of each disinfectant and a fresh culture ...control and ... See full document
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