[PDF] Top 20 Limitations of Ab initio predictions of peptide binding to MHC class II molecules.
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Limitations of Ab initio predictions of peptide binding to MHC class II molecules.
... Successful predictions of peptide MHC binding typically require a large set of binding data for the specific MHC molecule that is ...promise to circumvent ... See full document
10
Model for the peptide-free conformation of class II MHC proteins.
... concordance of the model with experimental ...predicted MHC backbone movement and the degree to which the probes are sensitive to the presence or absence of peptide ...predicted ... See full document
10
Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan.
... number of 100–200 peptides with characterized binding affinity is needed to derive an accurate description of the binding motif for MHC class II alleles ...the ... See full document
10
Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment.
... repertoire of MHC-II variants, the analysis of peptide-MHC-II interactions in this study was limited to DR ...antibody to MHC-II DR ... See full document
11
Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules.
... role of DM in peptide exchange, our data suggest an extension to antigenic exchange with ...1) to catalyze the removal of CLIP or non-CLIP peptides and their exchange by heterogeneous ... See full document
11
Design of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritis.
... The binding of the glycopeptides to A q or DR4 was determined relative to a biotinylated marker peptide in a competitive inhibition assay performed essentially as described elsewhere ... See full document
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Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A.
... binding of peptides to MHC class II molecules is not dependent on exact size, derivation of MHC class II ARB matrices followed an iterative ... See full document
16
GPS-MBA: computational analysis of MHC class II epitopes in type 1 diabetes.
... prediction of I-A g7 and ...adopted to determine the core nonamers in these ...performance of GPS-MBA was shown to be highly promising and much better than the other tools currently in ... See full document
9
Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes.
... for predictions on separate test set data. It is also informative to carry out a similar performance analysis for the binding prediction of individual 9- mer segments of the complete ... See full document
12
Patterns of MHC-G-Like and MHC-B Diversification in New World Monkeys.
... analysis of MHC-G-like cDNAs from ...tion of 19 positively selected positions from the peptide binding region (PBR), 16 of which have been predicted to interact with the ... See full document
20
Adaptor protein complexes AP-1 and AP-3 are required by the HHV-7 Immunoevasin U21 for rerouting of class I MHC molecules to the lysosomal compartment.
... enough of the residual m subunits existed to allow sorting of protein X, albeit slowly, such that after 50 days, protein X and U21 could reroute the bulk of class I MHC ... See full document
12
Modeling of Two-Stage Solidification: Part II Computational Verification of the Model
... stage of solidification is the same for both modified and unmodified ...stage of the solidification, the nucleation process unfolds in slightly different way, depending on the eutectic transformation ... See full document
6
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation
... Similar to EBV EBNA1, KSHV LANA1 also has a central repeat (CR) domain (321–937 ...comprised of repeats rich in glutamine (Q), glutamate (E), and aspartate ...inhibitor of MHC-antigen ... See full document
9
Expression of HLA-DR in pheripheral nerve of amyotrophic lateral sclerosis
... HLA-DR antibody (Dakopatts, Santa Barbara, CA), directed against the common framework of MHC class II antigens; a rabbit antiserum to the 200 KD subunit of human neurofilament protein ([r] ... See full document
8
Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
... effect of W6/32 on the lymphopro- liferative response of six healthy subjects to PPD, ...magnitude of the sup- pression mediated by the HLA I mAb varied with the antigens and donors ... See full document
8
Ab initio LSDA+U Study of Optical Properties of RVO
... reproduction of the exchange correlation energy and its charge derivative. To avoid this shortcoming, a scissors operation with a rigid upward shift of the conduction band has been used to ... See full document
8
Influence Of Industry Environment Adaptation To The Improved Performance Of Islamic Financial Institutions
... range of services (outreach), geographically Islamic banking has reached the Indonesian community in more than 103 districts / cities and 33 provinces in ...development of such services has increased the ... See full document
12
The ab-initio formulation of the second law of thermodynamics.
... tinha tentado, a duras penas, entender dois teoremas clás- sicos e fundamentais feitos por Clausius e Kelvin; eles me pareciam alguma coisa maravilhosa, como um milagre fei- to por um condão mágico, mas eu não ... See full document
5
Rev. Soc. Bras. Med. Trop. vol.45 número1
... de MHC-II (complexo principal de histocompatibilidade classe II) em amostras de epitélio cervical uterino, de pacientes com lesões de alto e baixo grau induzidas pelo ...I, II ou III ou foram ... See full document
6
Ab initio prediction of the polymorphic structures of pyrazinamide: A validation study
... rise to a zig-zag manner of interaction, with the same donor–acceptor pairs of atoms as for the case of both the experimental and the corresponding predicted α ...pairs of atoms ... See full document
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