[PDF] Top 20 A network-based approach to prioritize results from genome-wide association studies.
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A network-based approach to prioritize results from genome-wide association studies.
... Genome-wide association studies (GWAS) are a valuable approach to understanding the genetic basis of complex ...genetic association results into biological ... See full document
12
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
... equal to 1% and 2%, ...equal to 1% and 2%, respectively. Inadequate statistical power seems to be one of the limitations in our ...suggestive genome-wide suggestive candidate genes ...) ... See full document
16
Genome wide association studies for milk production traits in Chinese Holstein population.
... Genome-wide association studies (GWAS) based on high throughput SNP genotyping technologies open a broad avenue for exploring genes associated with milk production traits in dairy ... See full document
12
Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals.
... previous network-based analyses for schizophrenia [21, 24, 25], our analysis included more GWAS datasets and merged them into three groups according to genotyping ...module network with two ... See full document
16
Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies.
... evolutionary approach to detect functional elements ...UCSC Genome Browser (http:// genome.ucsc.edu) are two web-based tools that can be used to align multiple sequences from ... See full document
14
Quantifying the underestimation of relative risks from genome-wide association studies.
... simulation approach (see Methods for details). We describe the approach informally before describing our ...it to be causative with a given effect ...[3]) to simulate a large population of ... See full document
10
Use of genome-wide association studies for cancer research and drug repositioning.
... data from GWAS into clinical benefits, is to use the results to identify new indications for treatment with existing ...used to construct drug-related networks, aiding drug ...reasons ... See full document
13
Prediction of disease and phenotype associations from genome-wide association studies.
... constructed based on the Jaccard indexes were dense, which made it difficult to verify significant relationships common across populations and levels of ...translated to disease/phenotype ... See full document
10
Gene-centric characteristics of genome-wide association studies.
... greatly to genome-wide association (GWA) studies to identify novel disease susceptibility single nucleotide polymorphisms ...gene-centric approach, and the indirect ... See full document
8
Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis.
... Evidence from human genetic studies of several disorders suggests that interactions between alleles at multiple genes play an important role in influencing phenotypic ...applied to common multigenic ... See full document
12
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function.
... According to phenotypic fingerprints of the two strongest effector siRNAs/gene (Figure S3 and Materials and Methods), 37 of these genes were tentatively clustered into five distinct functional groups (Figure ... See full document
13
Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression.
... thought to be ...the association may be undetected in genome-wide association (GWA) studies due to low power to reach a high significance ...GWA studies. In ... See full document
7
A genomic background based method for association analysis in related individuals.
... interest to map the genes underlying QTs ...proportion–ranging from 30 to 80%–of variation is explained by genetic ...expected to contribute to this ...however, to be small (less ... See full document
7
META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies.
... points to improve have been formulated [30], it has only been mentioned that there is a need to replicate pathway association findings to avoid false positive results ...According ... See full document
21
Genome-Wide Association Studies of the Human Gut Microbiota.
... the association of ~200K host genotypes with the relative abundance of fecal bacterial taxa in a founder popu- lation, the Hutterites, during two seasons (n = 91 summer, n = 93 winter, n = 57 individuals collected ... See full document
22
Gene networks from genome wide association studies for pigs reproductive traits
... These results indicate that, based on this criterion, this model is the most appropriate for estimating the marker effects for the number of teats by presenting better fitting to the observed data ... See full document
177
On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
... the genome-wide level ...considered studies except for the ACG ...different from other studies, which indicates a different local LD structure; The ACG sample is from an Afro- ... See full document
9
Statistical power of model selection strategies for genome-wide association studies.
... Genome-wide association studies (GWAS) aim to identify genetic variants related to diseases by examining the associations between phenotypes and hundreds of thousands of ... See full document
14
Exploiting SNP correlations within random forest for genome-wide association studies.
... coming from the Wellcome Trust Case Control Consortium ...hence to provide a better understanding of tree-based ensemble methods in real-life conditions while, for computational reasons, most ... See full document
11
Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies.
... GWAS approach, called VEGAS, was used to conduct a gene-based association study ...information from all SNPs within a gene and accounts for the gene sizes, SNP density, and the LD ... See full document
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