[PDF] Top 20 Potential role of immunotherapy in advanced non-small-cell lung cancer

... discussed in this manuscript, it is noteworthy that immuno checkpoint inhibitors have estab- lished a new era for the treatment of advanced ...set of susceptible patients for this scenario ... See full document

... PFS of 2.2 months in overall population, and a PFS around ...months in Asian population.[7–9] The phase 4 Tarceva Lung Cancer Survival Treatment (TRUST) study recruited a total ... See full document

... Hepatotoxicity of usnic acid may restrict their potential medicinal use in cancer therapeutics ...most of hepatotoxicity in human was observed when high dose of usnic acid ... See full document

... Lung cancer leads cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC), the most prevalent subtype of this recalcitrant cancer, is ... See full document

... involved in the VEGF and EGFR associated sub-network, in addition to the GO terms related to cell ...proliferation. In this sub-network, KDR, FN1, TGFBI and PCNA were found to interact with 2 ... See full document

... point of view, Broglio et ...importance of SPP in understanding treatment effects for metastatic cancers ...[15]. In their study, when the median SPP was small, there was usually a ... See full document

... tumors of all different histological types appeared to benefit, a trend towards improved benefit was seen in patients with squamous cell histology, a subgroup that we have also observed to highly ... See full document

... level of controversy ex- ists in that miRNAs identified in the blood merely indicate changes in blood cells secondary to an overall poor health condition and are not specific to the presence ... See full document

... 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at ...underrepresented in randomized controlled trials ...the ... See full document

... signs of efficacy, resulting in the initiation of several phase III trials and the recent approval of this combination for use in the USA by Food and Drug ...benefits in a phase ... See full document

... tion in tumor cells is still unclear. The subcellular distribution of survivin plays a distinct role in the ability of the molecule to regulate cell ...interaction of the ... See full document

... effect of chemotherapy on the physical condition of patients with advanced lung ...with non-small cell lung cancer (in stages IIIB and IV) and Eastern ... See full document

... early-stage non-small-cell lung cancer (NSCLC) is considered a potentially curable disease following complete resection, patients have a wide spectrum of survival according to ... See full document

... quality of life benefits, but overall 2- year survival rates for this group remain <15% ...rate of 19- 32% and a me- dian survival time of 7,9 to 11,3 months ...ence in outcome among ... See full document

... effect of chemotherapy on the physical condition of patients with advanced lung ...with non-small cell lung cancer (in stages IIIB and IV) and Eastern ... See full document

... participate in the regulation of almost every cellular process investigated and that changes in their expression are observed in diseases such as ...30% of all protein-coding genes ... See full document

... reduction of complications derived from tumor biopsies, the possibility to anticipate progression and even the reduction of healthy costs with ambulatory non-invasive ...biomarkers in NSCLC. ... See full document

... 1004 advanced NSCLC patients enrolled are Han Chinese and were treated in three medical centers with exact same criteria for patient recruit- ment and information collection, limiting the potential ... See full document

... introduction of a targeted therapy for molecularly selected patient subgroups like patients with an EGFR activation mutation, impressive im- provements in the treatment of lung cancer ... See full document

... lesion in superior segment of left lower lobe (Figure ...transbronchial lung biopsy from superior segment of left lower lobe revealed squamous cell ...staging of III A T 2 N 2 M ... See full document