[PDF] Top 20 Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.

... The ALDH1 gene is located on chromosome 12 (12q24.2) and expresses a type of detoxify- ing enzyme, which contributes to the oxidation of intracellular aldehydes ...[5]. ALDH1 confers ... See full document

... CD166 expression could impede cancer cell release from a local ...[41]. In ovarian cancer, pharmacologic inhibition of ADAM proteins, or specific silencing of ADAM17/TACE, ... See full document

... studies and found a HR of ...bFGF expression. However, there was moderate hetero- geneity in the whole group (I 2 = ...source of heterogeneity through sensitivity analysis. The ... See full document

... limitations in this ...clinical value of miR-92a has been explored in CRC only for recent year, small sample size is contained in our meta-analysis, and as a ... See full document

... Subgroup analysis is a method for exploring the sources of heterogeneity and for increasing the reliability of an ...prognosis of NSCLC [39]. While the patients in the included ... See full document

... role of MUC1 was also attributed to the interaction of MUC1 and platelet-derived growth factor receptor β, as well as the transcriptional regulations of MUC1 on CTGF [11, ...development ... See full document

... existed in this meta-analysis should also be ...number of studies involved was relatively small, especially studies about mTOR ...stratifying analysis were difficult to conduct because ... See full document

... Enhancer of zeste homologue 2 (EZH2), a core protein of the polycomb-repressive complex 2 (PRC2), plays a vital role in the epigenetic maintenance of histone H3 lysine 27 (H3K27) re- pressive ... See full document

... choice of the statistical tools for analyses was an important ...intention of this analysis was to test the performance of published prognostic signatures in independent datasets ... See full document

... effect of BRAF-V600E mutation on patient survival separately based on study design RCT versus cohort and cancer ...plot analysis. We also assessed the heterogeneity of the studies using ... See full document

... Publication and reporting bias also has to be ...only in full publications. Another potential source of bias is related to the method used to extrapolate the ...included in the article or ... See full document

... proportion of cases showing up-regulation of BLCAP with neoplastic transformation, we performed additional quantitative IHC analysis of only the matched pairs of samples, consisting ... See full document

... this meta-analysis because PD-L1 expression were detected using DNA microarray[30, 31] or fluorescent RNAscope paired-primer ...protein expression with microarray-based gene-expression ... See full document

... Mechanisms of action of metformin and preclinical and ongoing studies in hematologic ...mechanisms of metformin have been proposed (Figure ...resulting in low ATP ... See full document

... system and up to 50% of affected patients will develop metastases during the course of their disease ...chance of long-term survival, with 30 to 40% of patients surviving 5 ...advances ... See full document

... sections and colorectal cancer cell line slides were blocked with CAS block (Life Technologies) for 1 hour at room temperature before incubation overnight at 4 degrees with pri- mary ... See full document

... number of patients with objective responses we had to focus on CBR ...aspects of oncology: There is an increasing debate on ideal clinical response criteria in active immunotherapy approaches ... See full document

... subjectivity in the data gathering and entry process, data were extracted independently by two reviewers (HK and MK) for each eligible ...independently in separate databases. The two completed ... See full document

... search of MEDLINE and EMBASE databases before January 2012, with no ...(WC)] and the risk of colorectal, colon, or rectal ...included in this analysis. 41 studies on ... See full document

... d in 3 2 p atien ts, 1 3 D u k es B an d 1 9 D u k es C , 2 2 h ad m etastases, m o st ferq u en tly in th e liv er (5 7 % ), an d 1 0 h ad lo cal recu rren ...ated in 7 o f th e 1 2 p atien ts w h o ... See full document