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[PDF] Top 20 The role of CD8+ T cells during allograft rejection

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The role of CD8+ T cells during allograft rejection

The role of CD8+ T cells during allograft rejection

... these cells as preformed and prepacked chemokines (26). Acute allograft rejection is characterized by an intense cellular immune response marked by influx of circulating leukocytes into ... See full document

12

Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

... Phenotyping of Nasal Polyp-Derived Tissue. To determine the immune cell proile of whole polyp cells, fresh and cultured (for 72 hours) cells were harvested (both adherent and ... See full document

12

Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines

Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines

... participation of IFN-γ as an important immuno- logical mechanism used by immune cells to elimi- nate tachyzoites of ...by the treatment of mice with specific neutralizing monoclonal ... See full document

26

Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites

Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites

... in the sporozoite forms from the arthropod vector to the mam- malian host that is responsible for the activation of the steady- state form of the parasite to its ... See full document

10

miRNA profiling of naive, effector and memory CD8 T cells.

miRNA profiling of naive, effector and memory CD8 T cells.

... regulators of gene expression during development and cell ...occur during antigen-induced T cell differentiation, the role of miRNAs in the process is not ... See full document

11

Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection.

Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection.

... from the interface of the gradient, and washed once in 1% ...NJ). Cells were washed 3 times in 1% PBS-serum, and cell suspensions were layered on a two-step discontinuous Percoll gradient ... See full document

6

Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes

Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes

... is the most com- mon chronic lung disease, which usually is associated with bronchial ...upon the role of CD4 + T cells, and relatively few studies have addressed the ... See full document

7

Resident CD8(+) and migratory CD103(+) dendritic cells control CD8 T cell immunity during acute influenza infection.

Resident CD8(+) and migratory CD103(+) dendritic cells control CD8 T cell immunity during acute influenza infection.

... upregulation of MHC II during acute influenza ...plots of – Dye (left) and + Dye (middle) treated animals are ...expression of MHC II on the CD11c + CD8 + DC (Gate I-filled) and ... See full document

7

Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection.

Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection.

... for the reactivation of latent Mtb infection are not well understood, but likely involve contributions from both the host and the ...appreciate the role that the host ... See full document

11

CD8+ T cell migration to the skin requires CD4+ help in a murine model of contact hypersensitivity.

CD8+ T cell migration to the skin requires CD4+ help in a murine model of contact hypersensitivity.

... and CD8+ T cells, but according to a number of studies, CD8+ T cells usually dominate the CHS effector response, while CD4+ T cells have a regulatory ... See full document

9

Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.

Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.

... capability of rapamycin T cells. We observed that treatment of rapamycin T cells with 2- DG resulted in a reduction of ATP levels in rapamycin to that treated with ... See full document

10

To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.

To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.

... to the activation of JAK2/STAT5 signaling pathway, which is also essential in the activation and function of immune ...h of T-cell activation ...fundamentally, the ... See full document

13

Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages.

Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages.

... levels of CAM-related-iNOS were noted in the two groups. Therefore, in T cell-PPARc ko recipients mice, macro- phages failed to differentiate into AAM in local ...that the PPARc-deficient Treg ... See full document

9

Induction of oral tolerance and the effect of interleukin-4 on murine skin allograft rejection

Induction of oral tolerance and the effect of interleukin-4 on murine skin allograft rejection

... produced during allograft rejection, in- volving macrophages, polymorphonuclear cells, CD8+ cells, and Th1 subtype CD4+ ...These cells contribute to the inflam- ... See full document

6

Immunopathology in ocular toxoplasmosis: facts and clues

Immunopathology in ocular toxoplasmosis: facts and clues

... protective role of IFN-γ in OT has been obtained using a synthetic polymeric com- plex of polyinosinic and polycytidylic acids, which is a potent inducer of ...IFN. The prophylactic ... See full document

10

CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.

CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.

... that the HVEM-BTLA trans- cosignaling system is strongly active in the development of CD8 T cells that protect against lethal VACV ...signals during T cell ... See full document

14

Expansion of NK cells and reduction of NKG2D expression in chronic lymphocytic leukemia. Correlation with progressive disease.

Expansion of NK cells and reduction of NKG2D expression in chronic lymphocytic leukemia. Correlation with progressive disease.

... and CD8 cell cytotoxic ...K562 cells at an Effector: Target (E:T) ratio of 5:1 in complete media supplemented with human AB serum and BD GolgiStop (BD ...control of degranulation, PBMCs were ... See full document

9

Cigarette Smoke Disturbs the Survival of CD8+ Tc/Tregs Partially through Muscarinic Receptors-Dependent Mechanisms in Chronic Obstructive Pulmonary Disease.

Cigarette Smoke Disturbs the Survival of CD8+ Tc/Tregs Partially through Muscarinic Receptors-Dependent Mechanisms in Chronic Obstructive Pulmonary Disease.

... experiments, the cholinergic pathway is involved in the regula- tion of CD8 + T cells [27], and increased ACh-binding to CD3 + CD8 + T cells in the ... See full document

11

Lymphocyte Differentiation and Effector Functions

Lymphocyte Differentiation and Effector Functions

... mechanism of several diseases, from cancer to graft transplantation rejection to pathogen immune ...inhibition of allograft rejection. Anti- gen presentation and the role ... See full document

4

Immunotherapy for Visceral Leishmaniasis: Ability of Factors Produced during Anti-leishmania Responses of Skin Test Positive Adults to Inhibit Peripheral Blood Mononuclear Cell Activities Associated with Visceral Leishmaniasis

Immunotherapy for Visceral Leishmaniasis: Ability of Factors Produced during Anti-leishmania Responses of Skin Test Positive Adults to Inhibit Peripheral Blood Mononuclear Cell Activities Associated with Visceral Leishmaniasis

... course of human Leishmania chagasi infections appears to be determined by the balance be- tween type 1 (T1) CD4+ and CD8+ T suppressor (Ts) cell ...history of visceral leishmaniasis ... See full document

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