[PDF] Top 20 Statistical power of model selection strategies for genome-wide association studies.
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Statistical power of model selection strategies for genome-wide association studies.
... Genome-wide association studies (GWAS) aim to identify genetic variants related to diseases by examining the associations between phenotypes and hundreds of thousands of ... See full document
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All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
... new statistical genetics ...number of SNPs have too small an effect to pass standard GWAS significance thresholds given current sample ...more of the polygenic effects in complex disorders and ... See full document
13
On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
... the genome-wide level ...terms of heights were adjusted and in the BBC, age, sex, height, recent chest infection and nurse were ...considered studies except for the ACG ...MAF of the ... See full document
9
Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.
... evidence of association in the prior GWAS of alcohol dependence that we ...evidence of replication for rs13160562 (p = ...the association of this SNP with alcohol dependence (p = ... See full document
7
Exploiting SNP correlations within random forest for genome-wide association studies.
... performance of RF methods either on simulated [11] or on real GWAS data [13], and in comparison with other methods, such as classical bayesian regression methods proposed in genomic selection [16] or other ... See full document
11
Gene networks from genome wide association studies for pigs reproductive traits
... implications. Selection acts over distinct genomic regions and depending on the population, initial selection can be on different genes and this may directly have an influence on which regions are under ... See full document
177
Properties of local interactions and their potential value in complementing genome-wide association studies.
... 63% of the local interaction SNP pairs in ARIC (61% in NFBC1966) mapped loci reported in previously published ...were genome-wide significant in the GWAS analyses in this study (Table 2, Table S2), ... See full document
9
META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies.
... study of the Lunenfeld-Taneberg Research Institute / Toronto [26], the German Lung Cancer Study [27, 28], and a study of the MD Anderson Cancer Center / Texas (MDACC Study, non- small cell lung cancer cases ... See full document
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Development and application of genomic control methods for genome-wide association studies using non-additive models.
... Genome-wide association studies (GWAS) comprise a powerful tool for mapping genes of complex ...inflation of the test statistic can occur because of population ... See full document
9
Genome wide association studies for milk production traits in Chinese Holstein population.
... greater power than haplotype-based approaches ...advantage of the single locus test is that it does not necessitate information of SNP positions and reconstruction haplotypes of multiple SNP ... See full document
12
A network-based approach to prioritize results from genome-wide association studies.
... GWAS studies for replication or for downstream analysis [20,21,25,27,28,33], ...These studies are limited by the problem of finding an optimal p-value ...number of genes might be too few to ... See full document
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Capturing the spectrum of interaction effects in genetic association studies by simulated evaporative cooling network analysis.
... genetic studies of several disorders suggests that interactions between alleles at multiple genes play an important role in influencing phenotypic ...investigate association with the phenotype only ... See full document
12
Arq. NeuroPsiquiatr. vol.70 número12
... pathophysiology of aneurysm ...series of common anatomic variants of the circle of Willis were found to be relat- ed to different aneurysm ...odds of aneurysm formation. Moreover, a ... See full document
2
PREDICTION OF PHENOTYPIC AND GENOTYPIC VALUES BY BLUPGWS AND NEURAL NETWORKS
... use of larger numbers of markers was limited due to computational resources, since it would be necessary to simulate thousands of markers used in hundreds of individuals under the number ... See full document
9
Design And Construction Of 300W Audio Power Amplifier For Classroom
... frequency of the ...output power amplifier from the audio signals. Output Power Amplifier is to amplify the audio signals and to reach the necessary amount of ... See full document
5
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
... Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research ...resources of the NHLBI and Boston ... See full document
13
Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.
... performed association tests on individual SNPs and haplotypes of SNP ...recessive model [7], we hypothesized that the subgroup of cases that shared 2 alleles identical by descent (IBD) at this ... See full document
8
Association of PTPN22 (rs2476601) and STAT4 (rs7574865) polymorphisms with Rheumatoid Arthritis in the Western Algerian population
... department of Rheumatology of Oran hospital “CHUO” (Centre Hospitalo-Universitaire ...not of Western Algerian ...grandparents of each individual possessing a Western Algerian ...basis ... See full document
7
Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies.
... 1% of the adult population worldwide ...Institute of Arthritis and Musculoskel- etal and Skin Diseases, about ...combination of genetic susceptibility and environmental factors ...architecture ... See full document
9
A Statistical Model for Regional Tornado Climate Studies.
... and model-fitting procedures are described using data from Kansas over the period ...influence of population density is decreasing. Inde- pendent of this relationship, it is found that tornadoes have ... See full document
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