[PDF] Top 20 The role of alpha-synuclein phosphorylation in synucleinopathies

... significant role in microtubules stabilization, oligodendrocytes projections, and ciliary structures 212 ...while the myelination process occurs 213, 214 . Remarkably, during the ... See full document

... was the presynaptic protein aSyn (Spillantini et ...found in neuronal processes (Lewy neurites - LN) as well as in astrocytes and oligodendroglial cells of PD patients (Kalia and Lang, 2016; ... See full document

... solely in spinal cord, brainstem and cerebellum (after six months of ...neurons in the forebrain (like CA1 pyramidal cell) displayed the same strong somatic aSN staining as cells ... See full document

... Impairment of -syn clearance caused by lysosomal dysfunction can be due to enzymatic ...player of this paradigm is glucocerebrosidade ...disease, the most common lysosomal storage disease (LSD) ... See full document

... at the involvement of Rab11-regulated recycling in aSyn ...investigated the role of Rab11 in aSyn secretion by manipulating its function in the cell, either ... See full document

... encompassing the positively charged N-terminus (residues 1-60), the aggregation-prone non amyloid components (NAC, residues 61-95), and the negatively charged C-terminus (residues 96-140), as can be ... See full document

... found in presynaptic nerve cells, and which the main purpose (if there is any) is still ...involved in many different functions in the human body, and, therefore, cannot be assigned to ... See full document

... PTM of alpha-synuclein, adequate standards may be less ...is phosphorylation at amino acid residues serine-87, serine-129, tyrosine-125, tyrosine-133 and ...tyrosine-136. In addition to ... See full document

... determinants in several model organ- isms. Sirtuin proteins have been implicated in neurodegenerative disorders, conditions that are strongly associated with aging ...[1,2]. In mammals, there are ... See full document

... that the very first steps of a-Syn self-assembly are severely affected by the presence of the cellular polyamine ...functions in living organisms, and their levels are maintained ... See full document

... function of α-syn, missense mutations or the long-term overexpression of α-syn may impair its function and render misfolded and/or toxic forms of α-syn, typically associated with PD and other ... See full document

... neurogenesis in the murine tg mThy1 WTS model due to changed differentiation but not survival of newly generated ...explain the known olfactory deficits in these mice. Furthermore, ... See full document

... tors of the structural and functional properties of proteins in health and pathological ...lines of evidence suggest that phosphorylation of ASYN may play an important ... See full document

... increase of the DQB1*06 MHC class II allele in idiopathic PD may indicate an association between sporadic PD and the immune system ...immunization of guinea pigs with homogenized MES ... See full document

... values of the same sample may substantially differ between measurements suggesting additional sources of error ...variability in a-Syn-nAbs-related OD measurement has previously been reported ... See full document

... PTMs in aSyn-enriched extracts from blood erythrocytes, easily accessible through a routine blood ...advantage of the thermo-stability of aSyn and of haemoglobin depletion 35 , ... See full document

... class of neurodegenerative disorders characterized by the presence of intracellular protein aggregates containing a-synuclein ...protein. The aggregated a-synuclein protein is ... See full document

... Inclusions in the brain containing a-synuclein are the pathological hallmark of Parkinson’s disease, but how these inclusions are formed and how this links to disease is poorly ... See full document

... compared the structures of AS fibrils from the E46K and A53T early-onset PD mutants to the WT using MAS ...near the mutation site, the 60 s and 80 s for A53T and large chemical ... See full document

... by the unicellular protozoan parasite Trypanosoma ...differentiates in the digestive tract. The differentiation of proliferative and non-infective epimastigotes into infective ... See full document