Rev. Bras. Hematol. Hemoter. vol.38 número2

rev bras hematol hemoter. 2 0 1 6;38(2):170–171

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Revista

Brasileira

de

Hematologia

e

Hemoterapia

Brazilian

Journal

of

Hematology

and

Hemotherapy

Images

in

Clinical

Hematology

Supraglottic

primary

B-cell

lymphoma

by

fluorine-18

fluorodeoxyglucose

positron

emission

tomography-computed

tomography

(18F-FDG-PET/CT)

Marta

Sánchez-Aguilar

_,

_Víctor

_Manuel

_{Pachón-Garrudo}

_,

Francisco

Javier

García-Gómez

a_{VirgendelRocíoUniversityHospital,Seville,Spain}

b_{VirgenMacarenaUniversityHospital,Seville,Spain}

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Articlehistory:

Received31December2015

Accepted19February2016

Availableonline16March2016

An82-year-oldmalepresentedwithdysphagiatosolidsand

liquids,weightloss,odynophagiaandleftcervicalpainfortwo

months.Feverornightsweatswerenotreported.An

otorhino-laryngologicalexaminationrevealedpermeablenostrils,free

cavum,erythemaofthearytenoidmucosa,andasuspicionof

amalignantlesionintheleftarytenoepiglotticfold.No

lym-phadenopathyofsignificantsizewaspalpable.Biopsyshowed

neoplasticcellswithpositiveimmunohistochemicalpattern

forLCA,Bcl-2,Bcl-6,Epstein–Barrvirus(EBV),CD5,CD30,CD10,

cyclinD1andMUM1,allowingthediagnosisofdiffuselarge

B-celllymphomaofgerminalcenterorigin.Moderatelyhigh

Ki-67labeling(60%)indicatedamalignantnatureofthetumor.

∗ _{Correspondingauthorat:DepartmentofNuclearMedicine,VirgenMacarenaUniversityHospital.41007,Seville,Spain.}

E-mailaddress:javier191185@gmail.com(F.J.García-Gómez).

Fluorine-18 fluorodeoxyglucose positron emission

tomography-computed tomography (18F-FDG-PET/CT)

revealed a hypermetabolic lesion resulting in left

trans-mural thickeningofthe larynx withslightdisplacementof

themidline(Figure1).

Primarylaryngeallymphomasareanextremelyrareentity

representing less than 1% of all extranodal lymphomas

withreportedmaleand left-sidedpredominance,and

loca-tion mainly supraglottic.1,2 _{A definite diagnosis can only}

be obtained by immunohistochemistry, as the radiological

findings are similar to primary squamous cell laryngeal

cancers.3

http://dx.doi.org/10.1016/j.bjhh.2016.02.005

1516-8484/©2016Associac¸ ˜aoBrasileiradeHematologia,HemoterapiaeTerapiaCelular.PublishedbyElsevierEditoraLtda.Thisisan

rev bras hematol hemoter. 2016;38(2):170–171

171

Figure1–Initialstagingusingfluorine-18fluorodeoxyglucosepositronemissiontomography-computedtomography (18F-FDG-PET/CT)revealedahypermetaboliclesionwithhighrateofcellproliferationthatextendedfromthebaseofthe tonguetotheleftvocalcord,resultingintransmuralthickeningandslightdisplacementofthemidline(axialandcoronal views)withSUVmax:37.3(SUVmediastinum:2.8).Anadditionalhypermetabolicfocusleftofthetransverseprocessesof D3andtwoabdominalpara-aorticlymphadenopathieswerealsoobserved.

Conflicts

of

interest

Theauthorsdeclarenoconflictsofinterest.

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1.SiddiquiNA,BranstetterBF4th,HamiltonBE,GinsbergLE, GlastonburyCM,HarnsbergerHR,etal.Imagingcharacteristics

ofprimarylaryngeallymphoma.AJNRAmJNeuroradiol. 2010;31(7):1261–5.

2.HornyHP,KaiserlingE.Involvementofthelarynxby

hemopoieticneoplasms:aninvestigationofautopsycasesand reviewoftheliterature.PatholResPract.1995;191(2):

135–8.