Anticancer agents
N-Phenyl-2-p-tolylthiazole-4-carboxamide derivatives: Syn-thesis and cytotoxicity evaluation as anticancer agents
... reliable anticancer agents is still a major challenge to medicinal ...various anticancer drugs, current anticancer drugs still have major limitations such as drug resistance, lack of ...
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Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary.
... other anticancer agents [5,6], a phase III study comparing the activity of irinotecan plus cis- platin versus carboplatin plus paclitaxel as a first-line treatment for CCC was conducted by the Japanese ...
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Mefloquine–Oxazolidine derivatives : a new class of anticancer agents
... To study the potential of MQ analogues as anticancer agents, it is necessary to develop and evaluate MQ deriva- tives. Prime goals are to enhance the effectiveness and to minimize side-effects, as well as ...
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Synthesis and biological evaluation of novel 6Hydroxybenzo[d]oxathiol2one Schiff bases as potential anticancer agents
... Abstract: With the aim of discovering new anticancer agents, we have designed and synthesized novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases. The synthesis started with the selective nitration at ...
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Electrochemical and calorimetric investigation of interaction of novel biscationic anticancer agents with DNA.
... ELECTROCHEMICAL AND CALORIMETRIC INVESTIGATION OF INTERACTION OF NOVEL BISCATIONIC ANTICANCER AGENTS WITH DNA. Biscationic amidines bind in the DNA minor groove and present biological activity against a ...
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Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
... The final goal of this work was to synthesize new HDAC inhibitors with anticancer effects. The first objective was to synthesize several compounds using the structures of SAHA and Belinostat as a starting ...
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Design, synthesis and biological evaluation of (E)2(2)quinoxalines, a promising and potent new class of anticancer agents
... 11–21 The biological uses of quinoxaline compounds include as antibacterial, antituber- cular, antimicrobial, antifungal, antimalarial, anti-inflammatory, antileishmanial, and antitumor [r] ...
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Discovering and exploiting bacterial proteins as anticancer agents
... chemical agents which act as lysosome inhibitors, such as ammonium chloride and chloroquine, two weak bases that accumulate inside the lysosome and dissipate its low acidic pH, by neutralizing H + ions ...
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Rubrolide analogues and their derived lactams as potential anticancer agents
... analogues and their derived lactams, which had not been previously analysed for their anticancer properties, were eval- uated in the present study for their cytotoxic potential against different human cancer cell ...
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Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents.
... peutic agents, which can often induce oxidative stress in cancer ...toxic agents may induce hormetic effect to stimulate cancer cell proliferation and tumor growth ...chemical agents have shown ...
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AlgiMatrix™ based 3D cell culture system as an in-vitro tumor model for anticancer studies.
... the anticancer effect of various drugs and formulations in a better fashion than conventional monolayer ...positive anticancer effects observed in 2D cultures often fail during in vivo ...various ...
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Cancer drugs inhibit morphogenesis in the human fungal pathogen, Candida albicans
... used anticancer drugs inhibit fundamental steps involved in eukaryotic metabolism or cell cycle like inhibition of DNA, RNA and protein synthesis (Liscovitch and ...the anticancer drugs targeting tubulin ...
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An update on anticancer triazene compounds
... There are ~3 760 000 guanine-rich regions in the human genome, which have the potential to form G-quadruplexes including those at the telomere end and promoter regions. In animal chromosomes, the telomerase enzyme (which ...
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Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction.
... NONSPECIFIC ANTICANCER DNA-INTERACTIVE AGENTS: AN ...chemotherapy agents against cancer may be classified as “cell cycle-specific” or “cell ...antimetabolic agents (DNA synthesis inhibition), ...
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Anticancer activity of lichen substances: a systematic review
... and anticancer, among ...demonstrated anticancer effects of lichens by inhibition of initiation, growth and invasion of several cancer cell types in vitro and in ...the anticancer activity and ...
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based chalcone hybrids and derivatives : synthesis and potent activity against cancer cell lines
... the redox centre does not affect the overall activity and selec- tivity of the lapachone imine derivatives and it was described as an alternative in the search for new anticancer agents consid- ering the ...
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Biological evaluation of isoniazid derivatives as an anticancer class
... and play a critical role in different biological processes [2]. This class of heterocyclic compounds also showed a broad spectrum of biological activities, such as anti- carcinogenic [3], antioxidant [4], ...
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Rev. dor vol.16 número3
... In Brazil, investigators are studying the use of Semmes-Weins- tein Monoilaments (MSW) and the Anticancer Agents-Indu- ced Neurotoxicity Questionnaire (QNIA) to evaluate CIPN. QNIA has shown high ...
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Synthesis of quinonebased Nsulfonyl1,2,3triazoles : chemical reactivity of Rh(II) azavinyl carbenes and antitumor activity art wovalença
... chemotherapeutic strategies have a high prevalence which often involves the development of small molecule anticancer agents that can be applied through blood circulatory motion targeting both cancer ...
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N containing thiophene nucleus : a new anticancer class
... Because of the importance of a thiophene nucleus to drug discovery and the continuous search for effective and safe anticancer agents (Fig. 1) (Palkowitz et al. 1997; Romagnoli et al. 2014), this study ...
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