Endothelin-1
Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.
... that endothelin-1 (ET-1), a potent vaso- active peptide, is increased during ECM and may contribute to the vasculopathy observed dur- ing malarial infection [6, ...
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Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome
... and endothelin-1 plays an important role in pulmonary vascular reactivity in ...of endothelin-1 in 18 preterm newborns with respiratory dis- tress syndrome who had no clinical or ...
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Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy
... Fig. 4: curcumin (Cur) attenuates endothelin-1 (ET-1) induction triggered by Trypanosoma cruzi infection. Top panels: ET-1 production was measured in T. cruzi-infected and uninfected mice, ...
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Endothelial dysfunction in high fructose containing diet fed rats: Increased nitric oxide and decreased endothelin-1 levels in liver tissue
... Amaç: Geli•mi• ülkelerdeki diyetlerde fruktozun tüketilme sıklığı son yıllarda giderek artmaktadır. Artan fruktoz tüke- timi insülin rezistansı olu•turarak endotel disfonksiyonuna yol açabilir. İnsülin rezistansı, ...
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Newborn hypoxia/anoxia inhibits cardiomyocyte proliferation and decreases cardiomyocyte endowment in the developing heart: role of endothelin-1.
... In the developing heart, cardiomyocytes undergo terminal differentiation during a critical window around birth. Hypoxia is a major stress to preterm infants, yet its effect on the devel- opment and maturation of the ...
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Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats
... of Endothelin-1 (ET-1) receptor blockade with bosentan (BOS) and macitentan (MAC) antagonists on altered renal function induced by CsA in normotensive and hypertensive ...
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Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma C-terminal pro-endothelin-1.
... ET- 1 in circulating blood (resulting from its short plasma half-life [14], its intermediate clearance by receptor binding in the pulmonary vascular bed [15], and its degradation by neutral endopeptidases ...
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Plasma nitric oxide, endothelin-1, arginase and superoxide dismutase in the plasma and placentae from preeclamptic patients
... The aim of this study was to determine parameters of NO metabolism in plasma and placenta of preeclamptic (PE) patients. It was conducted a case-control study at São José Hospital, Brazil. Thirty-three PE and 33 ...
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N-Acetyl Cysteine Inhibits Endothelin-1-Induced ROS Dependent Cardiac Hypertrophy through Superoxide Dismutase Regulation
... Serum samples were used for detection of BNP by western blot. These samples were subjected to sodi - um dodecyl sulfate polyacrylamide gel electrophore - sis (SDS-PAGE) method and transferred onto 0.45- µm pore-size ...
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Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice
... receptor antagonist, in T. cruzi-infected mice and did not find changes in parasitemia or parasitism (Roffê E, Souza ALS, Machado PP, Barcelos LS, Romanha AJ, Mariano FS, Silva JS, Machado CR, Tanowitz HB, Teixeira MM, ...
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Endothelin-1 serum levels in women with Rheumatoid Arthritis
... chArActerIstIcs of the study subjects The main features of the 63 women with RA and 65 controls included in this study are shown in Table I. The mean age (SD) of the patients was 53 ± 8 years. The majority were Caucasian ...
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J. vasc. bras. vol.6 número3
... to involve endothelial cell injury, with subsequent loss of normal vasodilatory mediators including prostacy- clin and nitric oxide. As a result, abnormal responses to vasoconstrictive mediators, including ...
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CPU0213, a novel endothelin type A and type B receptor antagonist, protects against myocardial ischemiareperfusion injury in rats
... plasma ET levels. By contrast, Feng et al. (15) showed that, in a model of L-thyroxin-induced cardiomyopathy, CPU0213 significantly inhibited elevated expression of ET-1 and dramatically decreased ...
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Gender differences in vascular expression of endothelin and ET
... 18. Wang X, Barber DA, Lew is DA, M cGregor CGA, Sieck GC, Fitzpatrick LA & M iller VM (1997). Gender and transcriptional regulation of NO synthase and ET-1 in porcine aortic endothelial cells. American ...
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Acute and subacute functional effects of relaxin-2 on human mammary artery
... This study constitutes the first description of relaxin’s functional effects on the human MA, a crucial vascular territory for the surgical approach to ischemic cardiomyopathy. In the present work, MA’s response to ...
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Endothelium: A Long Road from Mystery to Discovery
... of endothelin 1, markers of inlammation (intercellular adhesion molecules, selectins, cytokines), or markers of ibrinolysis (tissue plasminogen activator and plasminogen activator inhibitor), apoptotic ...
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Non-invasive Oxygen-Ozone therapy in treating digital ulcers of patients with systemic sclerosis
... tic effects in wound healing due to the property of re- leasing nascent oxygen, which has been shown to stimulate antioxidant enzymes. We aimed to assess the effects of ozone therapy on the healing of scleroderma DUs and ...
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Gene expression of ANP, BNP and ET-1 in the heart of rats during pulmonary embolism.
... as endothelin-1 ...ET- 1 has been subject of intense investigation concerning their potential role and secretion in response to acute pulmonary embolism ...
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Etanercept protects rat cardiomyocytes against hypertrophy by regulating in flammatory cytokines secretion and cell apoptosis
... Cardiomyocyte hypertrophy is a common pathological change of progressive cardiac function failure, which can induce increased ventricular stress, declined cardiac func- tion, cardiomyocyte death and tissues fibrosis ...
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Renal effects of Bunodosoma caissarum crude extract: prostaglandin and endothelin involvement
... In the present work, we tested the effects of tezosentan, an ET-1 competitive receptor antagonist with high affinity to both ETA and ETB receptors with greater potency for the ETA subtype (Clozel et al., 1999). ...
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