Human epidermal growth factor receptor
MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.
... Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family, plays a critical role in regulating multiple ...
22
J. Bras. Patol. Med. Lab. vol.51 número5
... Introduction: Breast invasive carcinoma of no special type (NST) is characterized by great morphological heterogeneity, and accounts for about 70%-80% of malignant breast tumors. The main prognostic factors are tumor ...
6
Clinicopathological Features and Prognosis of Metaplastic Breast Carcinoma: Experience of a Major Chinese Cancer Center.
... and human epidermal growth factor receptor 2 (HER2) expression (TNBC), and may express cytokeratin 5/6 (CK5/6) and/or epi- dermal growth factor receptor ...
13
Avaliação dos níveis serológicos de HER-2 : relevância clínica em cadelas com tumores mamários malignos
... Human epidermal growth factor receptor 2 (HER2) extracellular domain levels are associated with progression-free survival in patients with HER2-positive metastatic breast [r] ...
117
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival
... Epidermal growth factor inhibitors, antibodies and other molecules, such as erlotinib, gefitinib, cetuximab, panitumumab, trastuzumab and lapatinib, have been used in the treatment of colorectal, ...
9
Sao Paulo Med. J. vol.129 número6
... CONTEXT AND OBJECTIVE: Cyclooxygenase-2 (COX-2) and human epidermal growth factor receptor type 2 (HER-2) are associated with tumorigenesis. Studies have shown that HER-2 can regulate ...
9
The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes.
... Our data show that keratinocytes infected with S. aureus have the capacity to rapidly secrete IL-1alpha and IL-1beta. Since these cytokines are important for activation and recruitment of effector cells such as ...
14
LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells
... EGFR: epidermal growth factor receptor; EGR1: early growth response 1; FBS: fetal bovine serum; FPRL1: formyl peptide receptor-like 1; GVHD: graft- versus-host disease; HDPs: ...
11
Transgenic Soybean Production of Bioactive Human Epidermal Growth Factor (EGF).
... of human EGF (hEGF) in genetically- engineered soybean seeds and show that the recombinant EGF is indistinguishable from authentic human EGF and is bioactive at stimulating EGF receptor (EGFR) ...
17
ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS
... to epidermal growth factor receptor (EGFR) were injected together with cisplatin [5] they exerted a strong synergistic effect on the ability to reduce the size of tumors (KB human ...
3
Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.
... EGF receptor (EGFR). Our data give the first example of a Paramyxoviridae protein that contributes to the stimulation of EGFR and MAPK/ERK pathway and provides molecular basis to this activity. This pathway has ...
15
Study on invadopodia formation for lung carcinoma invasion with a microfluidic 3D culture device.
... of human lung cancer ...of epidermal growth factor (EGF) and matrix metalloproteinase (MMP) inhibitor, GM6001 on invadopodia formation by human non-small cell lung cancer cell line A549 ...
7
Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.
... in human cancer cell lines [6,7], and particularly the good clinical therapeutic efficacy of a series of antibodies or small molecular drugs that target specific proteins in human cancers reported in recent ...
12
J. Pneumologia vol.28 número3
... treatment modalities, targeting the tumor cell biological cycle. In this article, the authors review the role of some of the traditionally known tumor markers ( CEA , p53, NSE , K-ras), and describe the prevalence and ...
7
A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans.
... Platelet secreted VEGF-A, as a robust angiogenic factor, has gained significant attention for its grievous role in tumor biology[11–14]. Platelets also modulate wound healing and tissue regeneration by release of ...
16
Autonomous growth of BALBMK keratinocytes transfected with a retroviral vector carrying the human epidermal growth factor gene
... self-stimulated growth of trans- formed BALB/MK cells, the cells were selected with G418 and seeded onto new plates in the absence of exogenous EGF (Figure ...greater growth than those transformed with ...
5
PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.
... tumor growth and invasiveness and inducing effect on apoptosis of tumor cells, it has been identified as a tumor suppressor ...bone growth, and learning and memory ...
11
Arq Bras Endocrinol Metab vol.51 número4
... The multichaperone heat shock protein (Hsp) 90 complex mediates the maturation and stability of a variety of proteins, many of which are crucial in oncogenesis, including epidermal growth factor ...
13
Coarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylation.
... the epidermal growth factor receptor (EGFR), the intrinsic protein tyrosine kinase (PTK) activity of one receptor monomer is activated, and the dimeric receptor undergoes ...
20
Clinics vol.66 número8
... In conclusion, myocardial capillary density was lower in the diabetic group compared with the control group. Furthermore, the lower serum levels of the proangiogenic factors NO and sVEGFR-2, the higher level of the ...
6