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Predictive Value of Carotid Distensibility Coefficient for Cardiovascular Diseases and All-Cause Mortality: A Meta-Analysis.

Predictive Value of Carotid Distensibility Coefficient for Cardiovascular Diseases and All-Cause Mortality: A Meta-Analysis.

Regarding the publication bias of the six studies, the funnel plot was asymmetrically distrib- uted at the bottom, which indicated that small studies with small or negative risk estimates were missed in the present meta-analysis (Fig 4B). Using the trim-and-fill method to impute the missing studies, the adjusted risk estimates remained significant for the lowest quartile (1.40, 1.02–1.93, 95%CI) and a 1 SD decrease (1.26, 1.01–1.56, 95%CI), but not for a 1 unit decrease in DC (1.02, 0.98–1.06, 95%CI). In addition, the fail-safe N test indicated that the number of missing studies that would produce insignificant results was 33, which suggests that 5.5 (33/6) unpublished or undiscovered studies for every one study included in the present meta-analysis may change the significant results. Thus, the publication bias was insufficient to affect the predictive value of the lowest quartile and the per SD decrease in DC for all-cause mortality.
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PREDICTIVE VALUE OF CREATINE KINASE AND LACTATE  DEHYDROGENASE IN THE DIAGNOSIS OF PERINATAL ASPHYXIA

PREDICTIVE VALUE OF CREATINE KINASE AND LACTATE DEHYDROGENASE IN THE DIAGNOSIS OF PERINATAL ASPHYXIA

The cut-off LDH value of >580 U/L at 72 hours has 100% sensitivity with a specificity of 88%. LDH has a positive predictive value of 89.29% with a negative predictive value of 100% in diagnosing birth asphyxia. LDH is having more diagnostic value than CK-MB with more Area under ROC (Receiving operating Characteristic) value when compared to CK-MB at 8 hours and 24 hours (0.939 vs. 0.884 vs. 0.748), but both are excellent tests to differentiate asphyxiated and non-asphyxiated term neonates. CK-MB at 8 hours was better than 24 hours.
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Predictive Value of Mean Platelet Volume in Saphenous Vein Graft Disease

Predictive Value of Mean Platelet Volume in Saphenous Vein Graft Disease

9. Latour JG, Trudel JR, Campeau L, Côté P, Bourassa MG, Corbara F, et al. Platelet regeneration time and late occlusion of aortocoronary saphenous vein bypass grafts. Can Med Assoc J. 1980;122(12):1390-3. 10. Özlü MF, Öztürk S, Ayhan SS, Tosun M, Alçelik A, Erdem A, et al. Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study. Anadolu Kardiyol Derg. 2013;13(1):57-61.

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Hemostatic system changes predictive value in patients with ischemic brain disorders

Hemostatic system changes predictive value in patients with ischemic brain disorders

The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D- dimer, PAI-1, antithrombin III, protein C and protein S, factor VII and factor VIII, fi- brin degradation products, euglobulin test and th activated partial thromboplastin time – aPTPV) in relation to the level of the severity of ischaemic brain disorders (IBD) and the level of neurological and functional deficiency in the beginning of IBD manifestation from 7 to 10 days, 19 to 21 day, and after 3 to 6 months. The re- search results confirmed significant predictive value of changes of hemostatic sys- tem with the predomination of procoagulant factors, together with the insufficiency of fibrinolisys. Concerning the IBD severity and it's outcome, the significant predic- tive value was shown in the higher levels of PAI-1 and the lower level of antithrom- bin III, and borderline significant value was shown in the accelerated aggregation of thrombocytes and the increased concentration of D-dimer. It could be concluded that the tracking of the dynamics of changes in parameters of hemostatic system proved to be an easily accessible method with the significant predictive value re- garding the development of more severe. IBD cases and the outcome of the dis- ease itself.
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Evaluation of the Predictive Value of Umbilical Cord Serum Bilirubin Level for the Development of Subsequent Hyperbilirubinemia in Term and Late-Preterm Neonates

Evaluation of the Predictive Value of Umbilical Cord Serum Bilirubin Level for the Development of Subsequent Hyperbilirubinemia in Term and Late-Preterm Neonates

Conflicting results have been reported on the predictive value of UCS bilirubin level for subsequent hyperbilirubinemia. In a previous study, Bernaldo and Segre (13) showed that phototherapy is significantly associated with blood group incompatibility between the mother and newborn and unconjugated bilirubin level in the cord blood. In the mentioned study, 10% of neonates had ABO incompatibility, and 53% of the newborns with UCS bilirubin level > 2 mg/dl required phototherapy by the third day of life.

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Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence.

Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence.

Association of the FLIP/Sp1/Sp3 biomarker signature with clinical outcome (recurrence vs. non-recurrence) was evaluated using multiple statistical methods. The mean staining scores for protein expression in the two groups were compared with a Wilcoxon rank-sum test. p-values ,0.05 were considered signif- icant. The predictive value of each marker (FLIP, Sp1, and Sp3) for clinical outcome (recurrence or non recurrence) was first explored individually with logistic regression, and then the additive predicted value of the FLIP/Sp1/Sp3 signature and the extent to which they interacted with each other and with the Gleason score was explored with a backward selection model. The discrimination of the markers was identified with sensitivity-specificity analysis and the diagnostic value of the FLIP/Sp1/Sp3 signature was determined using area under the curve (AUC) for receiver operator characteristic (ROC) curves. Variables with p,0.15 were retained [14] in order to improve accuracy of the significant (p,0.05) variables reported. For the final model the Hosmer- Lemeshow Goodness of Fit test was performed. Significance levels and AUC for the ROC curve are reported. The analysis was carried out using SAS version 9.2 (SAS Institute Inc.) and STATA version 9.2 (STATA Corporation).
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Rev. Bras. Ginecol. Obstet.  vol.36 número1

Rev. Bras. Ginecol. Obstet. vol.36 número1

reasonable that serial evaluation of uterine artery Doppler velocimetry in second and third trimesters could help to determine normal development of fetal growth and deserve as a good predictor of pregnancy complications. The aim of this prospective longitudinal study was to investigate the sensitivity, speciicity, positive and negative predictive value of uterine artery Doppler ul- trasonography indices including Resistance Index (RI) and Pulsatility Index (PI) in second and third trimesters for prediction of pregnancy complications.

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Arq. Bras. Cardiol.  vol.72 número2

Arq. Bras. Cardiol. vol.72 número2

Myocardial bridging of the left anterior descending artery: evaluation using exercise thallium-201 myocardial scintigraphy. Predictive value of dypiridamole thallium imaging in a patient[r]

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Arq. Bras. Cardiol.  vol.87 número4

Arq. Bras. Cardiol. vol.87 número4

In the ABPM, we used DYNAMAP monitors (device for indirect noninvasive automatic mean arterial pressure). Pressure level readings were done using the oscillometric method according to the protocol of the British Hypertension Society19 and to the criteria established by the American Association of Medical Instrumentation20 and by the 3rd ABPM Guidelines of the Brazilian Society of Hypertension21. The ABPM monitor was adjusted to the patient’s waist, on the opposite side of the arm where the blood pressure was measured. The periods of alertness and night sleep of the ABPM were defined and programmed so that the pressure could be measured every twenty minutes during alertness and every thirty minutes during night sleep. ABPM was accepted as valid for analysis if a minimum of fourteen measurements had been taken during alertness and seven measurements had been taken during night sleep21. The following ABPM variables were assessed with a predictive value for PH:
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Rev. Soc. Bras. Med. Trop.  vol.46 número5

Rev. Soc. Bras. Med. Trop. vol.46 número5

Introduction: Toxoplasmosis may be life-threatening in fetuses and in immune-defi cient patients. Conventional laboratory diagnosis of toxoplasmosis is based on the presence of IgM and IgG anti-Toxoplasma gondii antibodies; however, molecular techniques have emerged as alternative tools due to their increased sensitivity. The aim of this study was to compare the performance of 4 PCR-based methods for the laboratory diagnosis of toxoplasmosis. One hundred pregnant women who seroconverted during pregnancy were included in the study. The defi nition of cases was based on a 12-month follow-up of the infants. Methods: Amniotic fl uid samples were submitted to DNA extraction and amplifi cation by the following 4 Toxoplasma techniques performed with parasite B1 gene primers: conventional PCR, nested-PCR, multiplex-nested-PCR, and real-time PCR. Seven parameters were analyzed, sensitivity (Se), specifi city (Sp), positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and effi ciency (Ef). Results: Fifty- nine of the 100 infants had toxoplasmosis; 42 (71.2%) had IgM antibodies at birth but were asymptomatic, and the remaining 17 cases had non-detectable IgM antibodies but high IgG antibody titers that were associated with retinochoroiditis in 8 (13.5%) cases, abnormal cranial ultrasound in 5 (8.5%) cases, and signs/symptoms suggestive of infection in 4 (6.8%) cases. The conventional PCR assay detected 50 cases (9 false-negatives), nested-PCR detected 58 cases (1 false-negative and 4 false- positives), multiplex-nested-PCR detected 57 cases (2 false-negatives), and real-time-PCR detected 58 cases (1 false-negative). Conclusions: The real-time PCR assay was the best-performing technique based on the parameters of Se (98.3%), Sp (100%), PPV (100%), NPV (97.6%), PLR (∞), NLR (0.017), and Ef (99%).
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J. Pediatr. (Rio J.)  vol.83 número5 en v83n5a12

J. Pediatr. (Rio J.) vol.83 número5 en v83n5a12

Results: We observed sensitivity of 90.7%, specificity of 89.1%, a positive predictive value of 72.1%, a negative predictive value of 96.9% and a positive likelihood ratio of 9.0 for the[r]

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Int. Arch. .  vol.21 número4

Int. Arch. . vol.21 número4

Statistical analysis was done using SPSS (“Statistical Package for Social Science”) program version 16. The mean values for ADC were calculated for the each group. We used a one-way ANOVA test to compare results of more than two groups and Student’s t-test to compare results between two groups. P value < 0.05 was considered significant. We determined the ADC cut-off value for differentiating malignant from benign sinonasal lesions using the Kappa test. With confirmed benign lesions, we compared conventional T2 WI MRI to DWI and with confirmed malignant lesions; we compared post contrast images with DWI. We evaluated diagnostic accuracy of diffusion-weighted MRI in terms of sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV).
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Braz. j. .  vol.77 número6 en v77n6a18

Braz. j. . vol.77 número6 en v77n6a18

The Dix and Hallpike maneuver have a positive predictive value of 83% and negative predictive value of 52% for the diagnosis of posterior and anterior semicircular canal BPPV, [r]

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Rev. Bras. Anestesiol.  vol.65 número2

Rev. Bras. Anestesiol. vol.65 número2

Results: A total of 2611 patients were assessed. In 7.4% of the patients, difficult intubations were detected. Difficult intubations were encountered in some of the patients with Mallampati scoring (MS) system Class 4 (50%), Cormack---Lehane classification (CLS) Grade 4 (95.7%), previ- ous knowledge of difficult airway (86.2%), restricted neck movements (cervical ROM) (75.8%), short thyromental distance (TMD) (81.6%), vocal cord mass (49.5%) as indicated in parentheses (p < 0.0001). MS had a low sensitivity, while restricted cervical ROM, presence of a vocal cord mass, short thyromental distance, and MS each had a relatively higher positive predictive value. Incidence of difficult intubations increased 6.159 and 1.736-fold with each level of increase in CLS grade and MS class, respectively. When all tests were considered in combination difficult intubation could be classified accurately in 96.3% of the cases.
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Arq. Bras. Cardiol.  vol.95 número6

Arq. Bras. Cardiol. vol.95 número6

This study sought to evaluate the predictive value of resting (pre-exercise) heart rate for cardiovascular and all- cause mortality, establishing a cut-off value in a sample of patients undergoing exercise stress testing (ET). Investigating the relationship between RHR and mortality is extremely important. The findings of our study both support and add new evidence to the existing literature regarding the predictive value of RHR for cardiovascular and all-cause mortality.

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Arq Bras Endocrinol Metab  vol.57 número4

Arq Bras Endocrinol Metab vol.57 número4

Negative predictive value (NPV) of Airma (20) and a Mutational Panel (38) according to the prevalence of malignancy. Figure 3[r]

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Rev. Bras. Reumatol.  vol.50 número1 en v50n1a05

Rev. Bras. Reumatol. vol.50 número1 en v50n1a05

While reafirming that the clinical exam still is the best medical practice, the author has proposed a new maneuver (Cecin‘s sign or “X” sign) to help the diagnosis of herniated lumbar disk, describing its biomechanical bases. However, the diagnostic performance of this maneuver has not been formally tested. Patients and Methods: The maneuver, which consists on the lexion of the lumbar spine while simultaneously performing the Valsalva maneuver, was tested in 45 patients with typical sciatic pain and herniated lumbar disk conirmed by magnetic resonance imaging (MRI), and in 21 patients with simple mechanical back pain with normal MRI. Lasègue’s sign was investigated concomitantly and the concordance with the “X” sign was assessed. Results: Concordance between the two tests was very low (Kappa = 0.17, Kappa < 0.4) and discordance was statically signiicant (P < 0.001). The “X” sign had a sensitivity of 73.3%, speciicity of 95.2%, positive predictive level of 97.1%, and negative predictive level of 62.5% in the diagnosis of herniated lumbar disk by MRI, while Lasègue’s sign showed sensitivity of 22.2%, speciicity of 95.2% (P < 0.001), positive predictive value of 90.9%, and negative predictive value of 36.4% (P = 0.153). Conclusion: Cecin’s sign had higher sensitivity, positive predictive value, and negative predictive value than Lasègue’s sign in the diagnosis of symptomatic herniated lumbar disk.
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Sao Paulo Med. J.  vol.124 número3

Sao Paulo Med. J. vol.124 número3

positive predictive value (92.3%), with a specifi city of 98% for the SBP diagnosis. On the other hand, in patients with a reagent strip result of grade 0 or 1, a diagnosis of ascitic fl uid infection could confi dently be ruled out because the negative predictive value was 100%. Our results are consistent with previ- ous reports. Vanbiervliet et al. showed that the Multistix 8SG rapid urine screening test had 100% sensitivity and specifi city for SBP diagnosis. 22 More recently, Castellote et al.

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PDF EN Jornal Brasileiro de Pneumologia 6 15 english

PDF EN Jornal Brasileiro de Pneumologia 6 15 english

Objective: Virulent strains of the Mycobacterium tuberculosis complex, under certain appropriate conditions, grow as characteristic ropes, bundles or serpentine cords known as cord factor or growth in cords. The objective of the present study was to evaluate cord factor detection as a method of achieving presumptive identification of the M. tuberculosis complex, comparing it to conventional typing tests. Methods: A total of 743 strains were analyzed from January of 2002 to December of 2005 in the Mycobacteria Sector of the Adolfo Lutz Institute, located in the city of Santos, Brazil. Samples were obtained from clinical specimens collected from patients with respiratory symptoms treated at basic health clinics in the greater metropolitan area of Santos. Ziehl-Neelsen-stained smears were prepared, 301 (40.5%) in MB/BacT broth and 442 (59.5%) on solid media, either Lowenstein-Jensen or Ogawa-Kudoh. Results: The sensitivity, specificity, positive predictive value and negative predictive value obtained during the performance comparison of the two methods (cord factor detection and conventional typing) using both isolation media were, respectively, 98.5, 88, 97 and 93%. The method was more sensitive on solid medium (100%), and the difference in sensitivity between the two media types was only 2.7%. Conclusions: Taking into consideration the results obtained, we conclude that, in laboratories with a high incidence of M. tuberculosis complex isolation and limited economic resources, cord factor detection is a fast and valid criterion for identifying these mycobacteria using liquid or solid medium. It also enables subsequent conclusive identification tests, as well as additional sensitivity tests when necessary.
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Einstein (São Paulo)  vol.15 número2

Einstein (São Paulo) vol.15 número2

by the Mann-Whitney test. To evaluate the BMS in differentiating patients with bacterial and aseptic meningitis, we calculated the measures of sensitivity, specificity, positive predictive value, negative predictive value and accuracy, and the Kappa coefficient, all measures with their 95% confidence intervals (95%CI). Calculations were made according to Altman’s recommendations (23) and using the R version 3.1.3

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