Protein interaction networks
Identifying hubs in protein interaction networks.
... large networks of protein-protein interactions has contributed to the identification of biochemical and signaling pathways, and to functional annotation of ...Such networks have been ...
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Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy
... The protein-protein interaction network for differentially expressed genes was constructed and ...in protein interaction networks tend to be present in pathways that co-occur in ...
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Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
... used protein-protein interaction networks and cluster analysis to comprehensively investigate the cellular pathways involved in gastric ...
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Context-specific protein network miner--an online system for exploring context-specific protein interaction networks from the literature.
... for protein name tagging and protein interaction relationship ...predicts protein interaction networks and may be suitable to researchers in biology and biomedical field who wish ...
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Predicting Pharmacodynamic Drug-Drug Interactions through Signaling Propagation Interference on Protein-Protein Interaction Networks.
... another protein within the same pathways [7, ...human protein interaction networks, Human Protein Reference Database (HPRD) (9,117 proteins and 36,248 interactions), Interologous ...
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Changes in protein interaction networks between normal and cancer conditions: Total chaos or ordered disorder?
... and protein-protein ...and protein-protein interaction (Zhou et ...biological networks is protein interaction networks (PINs) which can provide some more ...
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Specificity and evolvability in eukaryotic protein interaction networks.
... If protein properties impact on how they add and lose interactions, then the power law distribution observed in protein interaction networks is ...
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Fault tolerance in protein interaction networks: stable bipartite subgraphs and redundant pathways.
... of protein interaction networks: whether there exist alternative pathways that can perform some required function if a gene essential to the main mechanism is defective, absent or ...the ...
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Network compression as a quality measure for protein interaction networks.
... of protein interaction networks is a difficult and controversial ...each interaction is correct but no patterns emerge and complexes or pathways are impossible to ...Both networks share ...
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Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease.
... and protein-protein interaction (PPI) databases were combined to construct the PPI networks of differentially expressed (DE) genes in post mortem brain tissue samples of patients with ...
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Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
... relative protein abundance, mRNA processing, stoichiometry and interaction kinetics, complex formation and posttranslational ...known interaction dynamics between components of the circadian system ...
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Protein Interaction Networks Reveal Novel Autism Risk Genes within GWAS Statistical Noise
... variants hidden at the level of GWAS statistical noise can be discovered from networks of genes with related biological functions. Mapping of association data to a PPI network indeed revealed that, in both ...
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Exploring overlapping functional units with various structure in protein interaction networks.
... PPI networks resort to identifying cohesive protein complexes or functional modules [2–4] (Here, we do not distinguish protein complexes from functional modules because the underlying PPI ...
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Unveiling protein functions through the dynamics of the interaction network.
... Protein interaction networks have become a tool to study biological processes, either for predicting molecular functions or for designing proper new drugs to regulate the main biological ...such ...
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Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria
... large-scale protein-protein interactions are crucial to post- genomic systems ...large protein-protein interaction networks (Wallach et ...2014). Networks generated from ...
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Interaction studies of Gla-rich protein with bone morphogenetic proteins
... Gla-rich protein, or GRP, was the last member of the VKDPs to be identified and has been associated with ectopic calcification in tissues such as skin, vasculature and cartilage in cases of dermatomyositis and ...
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Application of RotaSVM for HLA class II Protein-Peptide Interaction Prediction
... II protein-peptide binding interaction facilitates the design of peptide-based vaccine, where the high rate of polymorphisms in HLA class II molecules poses a big chal- ...II protein-peptide binding ...
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Identification of colorectal cancer related genes with mRMR and shortest path in protein-protein interaction network.
... functional protein association ...existing protein-protein interaction data from STRING (Search Tool for the Retrieval of Interacting Genes), a weighted functional protein association ...
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Interaction of West-Nile virus capsid protein with lipid systems
... capsid protein associated with these organelles, an interaction that is essential for successful viral ...C protein hydrophobic α-helix 2 impair the protein association to LDs, suggesting the ...
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Understanding dengue virus capsid protein interaction with key biological targets
... for protein-protein interactions, and (v) hAPOEα N interacts directly with hAPOEα 4, we hypothesize that the proposed hAPOE-DENV C interaction 31 may occur via hAPOEα 4 binding to the DENV C domain ...
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