[PDF] Top 20 Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.
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Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.
... plethora of natural compounds with thera- peutic ...safe and pose minimal risk to normal cells ...alleviation of a wide spectrum of ailments, which include meningitis, acute hepatitis ... See full document
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Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics
... cause of death among genitourinary ...variations in the natural history and disease outcome have been ...introduction of personalized thera- peutics, making advanced stage bladder ... See full document
19
2-Methyl 2-butanol suppresses human retinoblastoma cells through cell cycle arrest and autophagy
... induced apoptosis and ...role in the execution phase of cell apoptosis ...Caspase-9 and caspase-3 are located upstream and downstream of the apoptosis ... See full document
7
AZD2014 Radiosensitizes Oral Squamous Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/G2/M Cell Cycle Arrest.
... target of rapamycin (mTOR) is a key regulator of translation that con- trols cell growth, proliferation, survival, and angiogenesis, and which is frequently dysregu- lated ... See full document
15
Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells.
... ylated Akt plays central roles in some fundamental processes, including cell proliferation, cell death, cell motility/adhesion, cell transformation, and ... See full document
10
Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis.
... activation of the different components of this pathway. In contrast, although PIK3CA mutations are considered driver mutations because they are linked to cell survival and ... See full document
8
PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3KAktmTOR pathway
... proliferation and promotes cell ...Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations ... See full document
9
Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia.
... observed in the other acute leuke- mia and CML ...reasons of this phenomenon? Hence, we car- ried out the next study to explore the mechanism of ribavirin’s anti-leukemia on Ph+ acute ... See full document
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Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells.
... processed in the STS-induced apoptosis that was dominantly inhibited by the caspase inhibitor ...size of the fragment is in accordance with the caspase-8-mediated cleavage ... See full document
14
Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells.
... inhibitor of epidermal growth factor receptors (EGFR, or ErbB/Her) in solid ...effect of lapatinib on ...K562 cells as an experimental model, we found that lapatinib simultaneously induced ... See full document
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Orientador: Doutor José Manuel Fuentes Rodríguez Co-orientador: Doutora Mireia Niso Santano Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universidad de Extremadura, Espanha
... inhibited by the mammalian target of rapamycin (mTOR), mTOR is a highly conserved serine/threonine kinase that is capable of integrating signals from many stimuli including amino acids, ... See full document
94
Nitric oxide and the resolution of inflammation: implications for atherosclerosis
... Recruitment of inflammatory cells, particularly mono- cytes and macrophages, is the major driving force behind plaque growth and ...dynamic and inflammatory cells are constantly ... See full document
6
Streptococcus agalactiae in human endothelial cells
... min) in 5% CO 2 at ...PBS and lysed with 0.5 ml of 25 mM Tris, 5 mM EDTA, 150 mM NaCl, and 1% IGEPAL (lysis ...number of vi- able bacteria associated (intracellular plus extracellular) ... See full document
8
“Via de sinalização mTOR no carcinoma urotelial da bexiga”
... do mTOR têm predominantemente efeitos citostáticos e, em ensaios clínicos, estes agentes parecem estabilizar a doença, embora tenham capacidade limitada para induzir a regressão significativa dos tumores (Gust e ... See full document
83
PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.
... presented in Figure 5A, the animals were treated with the drugs for a period of 22 ...days. In order to avoid overlooking transient effects on apoptosis, the tumors of the animals were ... See full document
12
Ordered patterns of cell shape and orientational correlation during spontaneous cell migration.
... VEG cells. Figure 2A shows that WT STA cells exhibit various dynamics of cell shape during spontaneous cell ...STA cell 1 maintained a larger Amp(h,t) at both 80u and 260u ... See full document
14
Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells
... malignancy in the biliary ...pharmacological and health benefits, including antioxidant, anti- inflammatory, anti-tumor, anti-thrombotic, antibacterial, and vasodilatory ...effect of TPs ... See full document
8
Flow Cytometry in the Study of Cell Death
... Changes in the morphology of cells undergoing apoptosis affect their light scattering ...decrease in forward light scatter can be ob- served in thymocytes triggered to undergo ... See full document
5
Efeito da suplementação de leucina sobre a proliferação de pré-osteoblastos da linhagem MC3T3-E1
... estudos in vitro, com diferentes tipos de células ...(23). In vivo, a suplementação da dieta de ratas Wistar em período gestacional com Leu, aumentou siginificativamente o peso corporal fetal, causou ... See full document
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Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.
... activity of AKT depends on the phosphorylation level at both the Thr308 and Ser473 residues as well as on its total protein concentration ...activity of AKT when both phosphorylated ... See full document
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