[PDF] Top 20 Design and synthesis of small molecule modulators of p53
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Design and synthesis of small molecule modulators of p53
... Instead of inhibiting MDM2 and/or MDMX directly, other strategies can be focused on upstream factors that regulate their stability, expression and ...One of the early events that lead to ... See full document
263
Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.
... developing small-molecule inhibitors of the toxin ...developing small- molecule inhibitors of protein-protein ...ference of BoNTAe constituting an unusually large ... See full document
18
Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
... risk of coronary artery disease ...sion of TRIB1 reduces secretion of VLDL and is associated with lower plasma levels of LDL cholesterol and triglycerides, higher plasma levels ... See full document
26
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator
... sirtuin modulators, their promiscuous nature is non-ideal for use as chemical probes and more selective molecules are ...tree of heaven), a plant used in Chinese and Korean traditional ... See full document
5
Renal Metastasis of a Malignant Myopericytoma: A Case Report and Review of Literature
... department of internal medicine by her family doctor with weight loss of 8 kg, persistent fatigue, and pain in the right hypochondriac ...region, and ultrasonography showed a mass on the upper ... See full document
6
Analysis of quality and cost of FeSiMg treatment master alloy vs. cored wire in production of ductile cast iron
... productions of high-quality ductile iron and vermiculwar cast iron are treatment with different vermin- nodularisers, ...practice of various techniques of introducing the reagents into molten ... See full document
4
Influence of vibrations during crystallization on mechanical properties and porosity of AlSi13Cu2 alloy
... number of defective products, so called defects shall approach to ...technology of production, introduces improvements which would help in accomplishment of this ...introduction of different ... See full document
4
Influence of tungsten and titanium on the structure of chromium cast iron
... crystallisation of cast iron deviates from the equilibrium ...carbon and chromium, which greatly reduces the temperature of its ...matrix of austenitic or austenitic-pearlitic character, as ... See full document
4
Explicit and implicit approach of sensitivity analysis in numerical modelling of solidification
... Keywords: Application of Information Technology to the Foundry Industry: Solidification Process: Numerical Tcchniqucs: Sensitivity Analysis; Borzndary Elcmcnt Mcthod.. Introd[r] ... See full document
6
An Analysis of Student Evaluations of Native and Non Native Korean Foreign Language Teachers
... field of non-English foreign language teaching by native and non-native teachers, the research conducted in EFL/ESL may help us identify universal ...professor of English, Peter Medgyes, whose native ... See full document
20
The Impact of E-Commerce Securi ty, and National Environment on Consumer adoption of Intern et Banking in Malaysia and Singapore
... ways of performing the same task (Roger, 1983; Agarwal & Prasad, ...experience and banking need is defined as the degree to which an innovation is viewed as being consistent with the existing values, ... See full document
20
Design Fabrication And Partial-Analysis Of A 2-Wheeler Prototype That Runs On Compressed Air
... actuation and the pulse control is achieved using an optical crank position sensor ...consists of vital components: optical emitter-receiver (OPB732), Astable multivibrator (LM555) [4] , TIP 122 Darlington ... See full document
5
Effect of Multipoint Sequential Water Mist Cooling of Casting Die on Microstructure and Mechanical Properties of AlSi11 Alloy
... metal, and at the latest at the beginning of crystallization of silumin, ...cooling of the other zones, which will no longer supply the zone 1 with the liquid metal,, but instead accelerate ... See full document
6
The Impact of the Expansion of the Bolsa Familia Program on the Time Allocation of Youths And Their Parents Lia Chitolina Miguel Nathan Foguel Naercio Menezes-Filho
... impact of the 2007 expansion of the Bolsa Família program to families with youths aged 16 to 17 years (entitled Benefício Variável Jovem) on the time allocation of youths and on the labor ... See full document
39
The small genetic world of Seriatopora hystrix
... density of connections within the cluster than between the ...function of the physical location of the reefs within a complex hydrodynamic ...Elizabeth and Lord Howe ...kilometres of ... See full document
15
On the synthesis and optimization of cascaded continuous-time Sigma-Delta modulators
... The only condition to be fulfilled for an efficient imple- mentation of this model in a simulator like MATLAB is im- posed by the integral in Eq. (4) to be solvable in closed form. Since usually criteria like ... See full document
5
Analysis of Structure and Abrasion Resistance of the Metal Composite Based on an Intermetallic FeAl Phase with VC and TiC Precipitates
... properties of metals and ceramics. Their low density, high strength and resistance to oxidation, combined with sufficient ductility and fracture toughness, make them an attractive material for ... See full document
4
Determinants and Consequences of the Website Perceived Value
... issue of growing interest to business, in particular to marketing at both academic and practitioner ...one of the most significant factors in the success of an organisation and an ... See full document
13
Calorimetric and Mössbauer spectroscopy examinations of ADI
... mechanism of isothermal transformation in ...results of calorimetric analysis of the thermal effects that take place in the specimen when heated after austempering and on the results of ... See full document
6
The Impact of Different Forms of Foreign Capital Inflow on GDPpc in CEE Countries during the Crisis up to 2012
... fixed and/or random effects of input ...role of so-called dummy ...part of the free term of the linear model, it is the question of the fixed effect (FE) ...part of the ... See full document
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