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[PDF] Top 20 Epigenetic Modifications: Therapeutic Potential in Cancer

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Epigenetic Modifications: Therapeutic Potential in Cancer

Epigenetic Modifications: Therapeutic Potential in Cancer

... a potential candidate for treating the AE-positive AML (Gao et ...involved in the oncogenesis of several ...SOCS3 in human colorectal cancer cells, and thus helps in preventing ... See full document

14

RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer.

RECQL1 DNA repair helicase: a potential therapeutic target and a proliferative marker against ovarian cancer.

... 4h in the presence of RNAiMAX (Invitrogen, Carlsbad, CA, USA), diluted 2-fold with the serum containing fresh medium, and were cultured at 37 °C for indicated ...fixed in ice- cold methanol for 2 ... See full document

8

Therapeutic Target Identification for Lung Cancer

Therapeutic Target Identification for Lung Cancer

... to potential drug ...lung cancer associated genes and hypothesized that the PPI network, derived from the gene signature, could be analyzed topologically to prioritize potential ...find ... See full document

4

Adenosine A3 receptors: a new therapeutic approach in cancer.

Adenosine A3 receptors: a new therapeutic approach in cancer.

... the cancer cell and how it differs from a normal ...of potential targets for new therapeutic ...far in the development of selective and potent adenosine receptor A 3 ligands, a current ... See full document

8

Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70.

Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70.

... million cancer deaths were estimated in 2008 worldwide, out of which ...from cancer in India [1]. Oral cancer has emerged as one of the top three causes of cancer-related deaths ... See full document

15

Epigenetic biomarkers as predictors of clinical outcomes in colorectal cancer

Epigenetic biomarkers as predictors of clinical outcomes in colorectal cancer

... Waddington in 1940s, is defined by reversible alterations that affect gene expression without altering DNA sequence 88,101–103 ...by epigenetic alterations, including DNA methylation at cytosine residues ... See full document

125

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.

... Genes in Cervical Cancer The amount of mRNA transcribed from 8,638 genes was compared between 43 CC samples positive for HPV16 and 12 normal cervical epithelial samples using the HG-Focus micro- ...the ... See full document

21

Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer.

Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer.

... E2F1 in respectively activating and repressing the transcription of the human mitotic centromere-associated kinesin (MCAK) promoter ...target in cancer ...levels in OvCa cell ...expression ... See full document

13

Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.

Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.

... with cancer development, reduces cellular differentiation and leads to the accumulation of undifferen- tiated cells that are susceptible to cancer ...whether epigenetic modifications have a ... See full document

15

A mathematical model of bimodal epigenetic control of miR-193a in ovarian cancer stem cells.

A mathematical model of bimodal epigenetic control of miR-193a in ovarian cancer stem cells.

... Ovarian cancer is the most lethal gynecological malignancy and the 5th leading cause of cancer death among women ...ovarian cancer has few symptoms early in its course, the majority of ... See full document

17

Identification of genes differentially expressed in breast cancer

Identification of genes differentially expressed in breast cancer

... Breast cancer comprises heterogeneous tumors with different clinical characteristics, disease courses, and responses to specific ...and epigenetic alterations in epithelial cells of mammary ... See full document

85

Minicircular DNA as a potential gene therapy vector in cervical cancer

Minicircular DNA as a potential gene therapy vector in cervical cancer

... applied in the clinical context, since they present low pathogenicity and high capacity of protein ...response in the ...the therapeutic gene to be ...pathogenic potential (Table 3) ... See full document

108

Epigenetic alterations in sepsis

Epigenetic alterations in sepsis

... word epigenetic literally means "additional changes that occur in the genetic ...with epigenetic mechanisms, including cancer of almost all types, cognitive and cardiorespiratory ... See full document

139

Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.

Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.

... changes in cell adhesion, polarity and migratory by in- terconverting epithelial cells into cells with mesenchymal / stem cell (SC) state ...activated in tumour cells and this progress enable these ... See full document

14

Oxidative stress: therapeutic approaches for cervical cancer treatment

Oxidative stress: therapeutic approaches for cervical cancer treatment

... Cervical cancer is mostly a consequence of the continuous evolution of non-invasive precursor lesions called cervical intraepithelial neoplasia (CIN) that are characterized by different degrees of cellular atypia ... See full document

10

Analysis of epigenetic alterations in homologous recombination dna repair genes in male breast cancer

Analysis of epigenetic alterations in homologous recombination dna repair genes in male breast cancer

... breast cancer (BC) is a distinct neoplasm with low but rising incidence, frequently diagnosed as advanced stage ...(HRR) in male BC, we aimed to explore the biomarker potential of aberrant promoter ... See full document

12

Distinct molecular features of different macroscopic subtypes of colorectal neoplasms.

Distinct molecular features of different macroscopic subtypes of colorectal neoplasms.

... pathways in colorectal tumorigenesis (Figure 1) ...SFRP1 in all ...changes in these ...ations in cancer-related genes in the later stages of colorectal ...aberrations in ... See full document

9

Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer

Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer

... players in the acid-resistant phenotype of tumour cells [22, 23] and attractive targets for cancer therapy alone or in combination with other drugs targeting metabolism [24], MCT2 appears to contrast ... See full document

10

Epigenetic of colorectal cancer:  a focus on microRNAs

Epigenetic of colorectal cancer: a focus on microRNAs

... miRNAs in extracellular body fluids strongly increased the number of studies showing deregulated expression of circulating miRNAs in cancer diseases 30 .... In this study the authors evaluated ... See full document

132

USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription.

USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription.

... unknown. In order to simultaneously maintain both stem cell identity and differentiation potential, ES cells possess unique bivalent chromatin domains at gene loci expressing developmental regulators ... See full document

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