[PDF] Top 20 Epigenetic regulation of micrornas in prostate cancer

... developed in the last century (Capasso, ...for prostate-specific antigen (PSA) constituted the greatest improvement over the past three decades (Shen and Abate-Shen, 2010, Hernandez and Thompson, ... See full document

... expression of a subset of CPGs included in this study: 81 tumor suppressor genes and 17 ...regulators of both gene groups, and the number of intersections among these sets of ... See full document

... levels of miR- let-7b can be an indicator of ...decreases in the plasma expression of let-7b were associated with worse prognosis and poorer ...reduction in serum miR-223 expression was ... See full document

... Prostate cancer is one of the most common malignant tumors throughout the ...treatment of prostate cancer has improved during the past decade, ad- vanced stages of the ... See full document

... resistance in cancer cells are ...up-regulation of ABCB1 efflux pumps during treatment, directing the upsurge of different acquired resistance ...event in the development ... See full document

... out in TMAs of human prostate cancer, BPH, PIN and non-neoplastic tissue ...deparaffinized in xilol and rehydrated in decreasing solution of ...ethanol. In order to ... See full document

... results in vitro show that miR-302s and miR-369s play a role as tumor suppressor miRs and influence cancer reprogramming, acceleration of MET, inhibition of the Cyclin/Cdk axis, suppression ... See full document

... number of the epithelial cells of the luminal compartment of PIA expressed low levels of ...CD38. In contrast, mature luminal cells expressed high levels of ...increase in ... See full document

... antigen of the prostate 1 (STEAP1) was discovered as an up-regulated prostate-specific cell-surface antigen in human prostate cancer and in spontaneous transgenic mouse ... See full document

... overexpressed in several kinds of tumors, but the mechanisms underlying its overexpression remain to be ...level, in regulation of gene induction/expression, proliferation, cell ... See full document

... 20-30% of the genes are potential miR targets, considering that usually many mRNAs are regulated by a single miR and various miRs regulate a single gene expression ...amount of miR in each cell ... See full document

... expression of the SEMA3B, HYAL3, HYAL1, HYAL2, TUSC2, RASSF1, ZMYND10, NPRL2, TMEM115 and CACNA2D2 genes in the breast cell lines were analyzed by quantitative real-time ...μg of total RNA using the ... See full document

... arrangements of prostatic ...glands of various sizes including branching glands ...consists of sheets of tumour, individual cells, and cords of cells ...subtypes of prostatic ... See full document

... functions in prostate development and tumor suppression ...Loss of Nkx3.1 expression is a frequent event in prostate tumorigenesis and has been attributed to various mechanisms ... See full document

... located in the first exon of CXorf1 gene is hypomethylated in stage ...is in accordance with survival analysis performed, which showed that low methylation levels are associated with a poor ... See full document

... Disruption of normal patterns of covalent histone modifications is another hallmark of ...One of the most characteristic examples is the global reduction of the trimethylation of ... See full document

... switching of gene expression). In Haemophilus influenzae and pathogenic Neisseria, the random switching of the modA gene, associated with a phase-variable type III restriction modification (R-M) ... See full document

... methylation of the TERT promoter, on the other hand, has generated conflicting mechanistic ...inconsistencies in the precise definition of the regions that constitute the epigenetically vulnerable ... See full document

... action of formaldehyde was blocked with 2 mL Glycine 10X at ...1X in 10% protease inhibitor cocktail II (PIC) and centrifugation at 800g, 5 minutes at 4ºC were ...periods of shaking, and then with a ... See full document

... function of other kinesins are fairly well understood, much less is known about their regulation at the DNA ...roles of the transcription factors Sp1 and E2F1 in respectively activating and ... See full document