[PDF] Top 20 Non-Coding RNAs : multi-tasking molecules in the cell
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Non-Coding RNAs : multi-tasking molecules in the cell
... involved in mRNA down-regulation. This mechanism requires the formation of a sense:anti-sense pair of transcripts that are then processed into ...from the same loci (cis-NATs) or from different loci ... See full document
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Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes
... probably the highest risk factor for heart failure (Li et ...still the major cause of death in the elderly in industrialized ...to the neonatal heart, adult mammalian hearts lost ... See full document
121
Deep sequencing analysis reveals distinctive non-coding RNAs when comparing tumor multidrug-resistant cells and extracellular vesicles with drug-sensitive counterparts
... on the cellular context, the same miR may have tumor-suppressor or tumor-promotion ...Therefore, the miR relative levels described above should be interpreted taking into account the ... See full document
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Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage
... inhibited in the G2/M cell cycle, and the production of profibrotic cytokines that can stimulate the proliferation and transition of pericytes to myofibroblasts was induced ...(6). ... See full document
11
Enhancing reprogramming and transdifferentiation through long non-coding RNAs
... how the lncRNA NORAD could affect stem cells stability, viability and pluripotent ...colleagues, the absence of NORAD triggers chromosomal instability in the human colon cell line ... See full document
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Contribution to unveiling the roles played by small non-coding RNAs in the biology and pathogenesis of Burkholderia cepacia complex bacteria
... considered. In the systems already characterized, the RNA acts as an antitoxin and the protein functions as a toxin responsible for membrane changes are described for proteins causing membrane ... See full document
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A long non-coding RNA regulating cellular reprogramming
... Back in 1961, Jacob and Monod (Jacob & Monod, 1961) inferred for the first time the existence of RNAs capable of repressing the production of ...of the functions of what we ... See full document
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Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle.
... Ankrd2 in human myotubes AdenoAssociated Virus (AAV) was used to deliver shRNA into primary muscle cells during ...differentiation. The sequence of the siRNA from Ankrd2 exon 1–2 that reduced ... See full document
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Long non-coding RNAs as potential therapeutic targets in human breast cancer
... on the same or opposite strand, respectively; (3) bidirectional, when its expression and of a neighboring coding transcript on the opposite strand are initiated in close genomic proximity; (4) ... See full document
44
Comparative analysis of human protein-coding and noncoding RNAs between brain and 10 mixed cell lines by RNA-Seq.
... that multi-exon genes could encode different isoforms through alternative splicing and different isoforms have different protein-coding ...potential. In addition, gene expression usually exhibit ... See full document
8
Iron deprivation in synechocystis: inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling
... involved in the metabolism of carbon and nitrogen has been reported before (Muro- Pastor et ...reflect the prioritization of one path- way over the other depending on the environmental ... See full document
21
Revealing potential long non-coding RNA biomarkers in lung adenocarcinoma using long non-coding RNA-mediated competitive endogenous RNA network
... long non-coding RNAs (lncRNA) biomarkers in lung adenocarcinoma (LAD) using lncRNA-mediated competing endogenous RNAs (ceRNAs) network ...using the hypergeometric test. ... See full document
10
Study of the Long Non-Coding RNA C/EBPβ-AS in Cutaneous Melanoma
... RNA molecules were originally considered to mainly function as intermediates between genes and respectively encoded ...since the discovery of ribosomal RNA (Palade, 1955) and transfer RNA (Hoagland et ... See full document
85
Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance: potential biomarkers for LSCC.
... coding RNAs (lncRNAs), more than 200 nt in length, have gained increasing attention in cancer ...protein- coding genes: sense lncRNAs, antisense lncRNAs, bidirectional lncRNAs, intronic ... See full document
9
Identification and characterization of long non-coding RNAs related to mouse embryonic brain development from available transcriptomic data.
... involved in the development of brain ...stages, the information is limited for unannotated regions because they are unable to detect unknown gene structure ...intergenic non-coding ... See full document
16
Role of long non-coding RNAs in parasite differenciation
... detectable in one of the two ...overexpression. The overexpression plasmid (pDex-577) has an aldolase 3’UTR downstream of the transgene that stabilizes the transcript in ... See full document
51
Non-coding repeat insertion and RNA-mediated neurodegeneration
... progression in disorders caused by repeat ...that the identification of the repeat insertion will be applied in the investigation of suitable therapies that rescue or ameliorate ... See full document
179
The role of Ctk1 kinase in termination of small non-coding RNAs.
... that the readthrough observed at NNS targets is due to an altered CTD phosphorylation pattern in ctk1 D ...phosphorylation in vivo [52], subtle effects on the other phosphoiso- forms might ... See full document
13
Role of non-coding RNAs in non-aging-related neurological disorders
... Protein coding sequences represent only 2% of the human ...of the genome is actively transcribed as non-coding RNA ...These non-coding RNAs are emerging as key ... See full document
10
A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic Events.
... guiding the present study is that, in order to prioritize non-coding mutations in cancer and eventually discover new cancer drivers, one should take into account these dual selection ... See full document
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