[PDF] Top 20 The prognostic role of mTOR and p-mTOR for survival in non-small cell lung cancer: a systematic review and meta-analysis.

... existed in this meta-analysis should also be presented. First, the number of studies involved was relatively small, especially studies about mTOR ...stratifying ... See full document

... be of interest for future studies ...tumor cell migration to lymph nodes only can occur in functional lymphatic vessels mostly found in the tumor periphery and not in ... See full document

... regression analysis for SPP was conducted to clarify which clinical factors could affect SPP (Table ...3). The year of trial initiation was a significant factor (regression coefficient of ... See full document

... is the formation of new blood vessels from the endothelium of existing vasculature, plays a pivotal role in tumor growth, progression and metastasis ...series of ... See full document

... as prognostic markers of 3-month survival after diagnosis of stage IV non-small cell lung cancer ...a cancer treatment center in southern ... See full document

... a role in the survival of cancer cells in breast, prostate, ovary, and brain tissue ...promotes survival of NSCLC cell [29]. Recently, a ... See full document

... vesicles of endolysosomal origin, released by several cytotypes in physiological and pathological ...cells of the tumor microenvironment, modulate tumor progression, angiogenic switch, ... See full document

... databases and meeting abstracts searches, a total of 1,368 records were ...rounds of assessment, 26 trials covering 7,839 patients met all the inclusion criteria, and comprised ... See full document

... Background and objective As there is a sharp increase in the incidence of lung cancer in women in re- cent years, it has brought broad concerns with its unique ... See full document

... values and ranges were derived for quantitative variables and mRNA gene ...means of absolute frequencies and percentages. The Kruskal- Wallis test was used to check for ...Differences ... See full document

... prevalence of thrombocytosis did not differ sig- nificantly between ages, sex and ...On the contrary, in the present study we identified significant association between elevated ... See full document

... especially in melanoma generated a tremendous research effort to block this signaling pathway for cancer ...treatment. The usage of most available multi-kinase inhibitor at that time, ... See full document

... Subgroup analysis is a method for exploring the sources of heterogeneity and for increasing the reliability of an ...affects the prognosis of NSCLC [39]. While ... See full document

... This meta-analysis provided additional insights into use of PCI in patients with ...NSCLC. The analysis included 12 clinical studies (6 RCTs and 6 nonRCTs), involving a ... See full document

... The prognostic predictive value of survivin expression and that of nuclear staining versus cytoplasmic staining in several malig- nancies, including NSCLC, have been investigated ... See full document

... standardization of evaluating vascular invasion and quality control is needed. In addition, an important issue that needs to be taken into account is the type of adjuvant therapy that ... See full document

... target of rapamycin (mTOR)/AKT pathway has been linked to the pathophysiology of several neoplastic diseases ...Activation of this pathway can be a result of mutations in ... See full document

... supports the involve- ment of systemic inflammation in cancer develop- ment and progression ...by the concentration of acute phase proteins, CRP, fibrinogen, ferritin, ... See full document

... redirect and reprogram patient T-cells have shown promising results in the treatment of acute lympho- blastic leukemia and non-Hodgkin’s ...with the ability to target ... See full document

... In the present study, the number of lym- ph nodes removed in the ELRC group was signifi- cantly lower than the TLRC ...group. The extent of pelvic lymph ... See full document