[PDF] Top 20 The role of NRARP in the pathogenesis of T-cell acute lymphoblastic leukemia
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The role of NRARP in the pathogenesis of T-cell acute lymphoblastic leukemia
... resuspended in Laemmli buffer and denatured at 90ºC for 5 ...(50µg-100µg of protein depending on the protein to be analyzed), were loaded in a SDS- PAGE gel (10%, 12%, 14% or 16% of ... See full document
54
Potentiation of a novel palladium (II) complex lethality with bee venom on the human T-cell acute lymphoblastic leukemia cell line (MOLT-4)
... one of the most remarkable drugs which is used separately or in combination with other chemotherapy agents to treat different types of tumors ...Despite the success of cisplatin ... See full document
7
Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia.
... gene). The rationale for grouping patients with any methylated gene (regardless of the number of methylated genes) in the same methylation group was derived after statistical ... See full document
14
Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia.
... time of diagnostic from 11 leukemic patients (10 pre-B and 1 pre-T) were positive for HHV-6 DNA (table ...determined the HHV-6 copy number in the leukemic patients using a standard ... See full document
5
The treatment of acute lymphoblastic leukemia has come a long way but the best is yet to come
... markers in MRD monitoring based on conventional polymerase chain reaction (PCR) for immunoglobulin (Ig) and T-cell receptor (TCR) rearrangements, and Sil-Tal1 deletion in patients with ... See full document
2
Determining the prognostic significance of PI3K/Akt/mTOR and JAK/STAT5 signaling pathways in pediatric acute lymphoblastic leukemia using single-cell analysis
... Heterogeneity of functional responses to IL-7 in B-ALL patient ...analysis of viability and cell size was performed in this cell ...10ng/ml of IL-7 and analyzed for ... See full document
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Immunoglobulin genes and T-cell receptors as molecular markers in children with acute lymphoblastic leukaemia
... Seriu T, D’Aniello E, Willemse MJ, Fasching K, et al. Molecular detection of minimal residual disease is a strong predictive factor of relapse in childhood B-lineage acute ... See full document
7
The new therapeutic horizons for acute lymphoblastic leukemia : literature review
... After T cell activating therapies, severe neurologic toxicities can ...is the most common adverse reaction however seizures are also possible. The encephalopathy is generally mild and ...found ... See full document
30
Acute Lymphoblastic Leukemia in a Young Adult Presenting as Hepatitis and Acute Kidney Injury
... to the picture at presentation, hepatocellular injury is commonly observed in ALL patients during their treatment course secondary to liver injury from medications, post-chemotherapy viral infections ... See full document
4
The role and therapeutic potencial of regulators and effectors of PI3K/Akt pathway in T-cell leukemia
... Acute Lymphoblastic Leukemia is a type of leukemia characterized by an abnormal proliferation of immature cells of lymphoid lineage in the bone marrow or ... See full document
48
The pathogenesis of tropical spastic paraparesishuman T-cell leukemia type I-associated myelopathy
... paraparesis/human T-cell leukemia type I-associated myelopathy (TSP/HAM) is caused by a human T-cell leukemia virus type I (HTLV-I) after a long incubation ...loss, the ... See full document
7
Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications
... Alterations in signaling pathways play distinct roles in the etiology, maintenance and progression of T-ALL (Figure ...deregulated in this type of leuke- ...targeting ... See full document
7
The role of NRARP in the regulation of Wnt signaling pathway in T-cell acute lymphoblastic leukemia
... In the canonical Wnt pathway, in the absence of WNT ligands, cytoplasmic levels of β-catenin (CTNNB1) are kept very low due to its constitutively phosphorylation and degradation ... See full document
53
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
... is the PI on an existing Institutional Review Board (IRB) approval for tissue banking, entitled ‘‘Protocol 070678: Permission to Collect Blood and/or Bone Specimens and/or Tumor Samples and/or Saliva from Patients ... See full document
14
Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.
... identity of the LTβR‐expressing stromal cells and the mechanisms by which their activation promotes leukaemogenesis remain to be ...activate the noncanonical NF‐κB pathway (Ganeff et al, 2011) ... See full document
20
The role of polyunsaturated fatty acids in bacterial pathogenesis
... upstream of the cascade. The upstream regulation of the PMK-1 cassette in ...whether the tissue is the intestine or the epidermis (Figure 6 ...). In ... See full document
95
A Novel BCR-ABL1 Mutation in a Patient with Philadelphia Chromosome-Positive B-Cell Acute Lymphoblastic Leukemia
... ALL, in which complete remission can be achieved in 95% of the ...monitoring of Ph + hematological diseases has become an integral part of the clinical manage- ment ... See full document
10
The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection
... part of the hosts defense against intracellular bacterial ...antigen-specific T cell-mediated activation of macrophages, which are the major effectors of ... See full document
8
Enhanced levels of the apoptotic BAXBCL-2 ratio in children with acute lymphoblastic leukemia and high-risk features
... that leukemia is characterized by an impaired balance between the proliferation of blood cells and their capacity to undergo ...apoptosis. The aim of this study was to examine ... See full document
5
The effects of anti-leukemia chemotherapy on LKB1-AMPK pathway functioning in acute myeloid leukemia cell lines
... concentrations of ATRA [57, 63, 64]. Thus, the transcription of genes involved in differentiation is disrupted blocking the normal promyelocytic maturation [57, 63, ...64]. In an ... See full document
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