[PDF] Top 20 The RNA interference revolution
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The RNA interference revolution
... others. The main advances in the use of RNAi have being made in the antiviral and anticancer ...to the HIV-2 genome lost their ef- fect due to the emergence of viral variants harboring ... See full document
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Specific RNA Interference in Caenorhabditis elegans by Ingested dsRNA Expressed in Bacillus subtilis.
... of the two types of bacteria in ...of the natural aging process, as it is not known if its magnitude changes over time as the organism ...of the aging process per se. With this line of ... See full document
15
Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma
... of the target genes of proliferation, anti-apoptosis, or cell cycle progression by binding directly to high-affinity DNA binding sites or by associating with other transcription ...STAT3-targeting RNA ... See full document
10
Bivalent RNA Interference to Increase Isoflavone Biosynthesis in Soybean (Glycine max)
... in the hairy roots of soybean that arose from cotyledons transformed with ...define the roles of these genes in the accumulation of flavones and ...that the new constructions were very ... See full document
8
Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.
... of the human OSMR or blockade of the human LIFR by LIF-05 treatment, we clarified the receptor usage for rat OSM on human ...of the human OSMR by siRNA ...of the hLIFR by LIF-05 ... See full document
12
RNA interference of gonadotropin-inhibitory hormone gene induces arousal in songbirds.
... If the suppression of GnIH neuronal activities in the brain can induce arousal, there may be a significant relationship between the activities of birds and GnIH neuronal fiber distributions in ... See full document
12
Effects of Trypanosoma brucei tryptophanyl-tRNA synthetases silencing by RNA interference
... that the outcome of RNA interference on TbTrpRS2 is a rapid decrease of mitochondrial activity, leading to a rapid cell ...death. The rapid rate which mutant phenotypes develop after ex- ... See full document
6
RNA interference of myocyte enhancer factor 2A accelerates atherosclerosis in apolipoprotein E-deficient mice.
... are the leading causes of death and disability in the western ...in the development of atherosclerosis. The myocyte enhancer factor 2A (MEF 2A) gene is known to play diverse roles in ... See full document
11
Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference.
... by the plasma membrane (Figures S1, S2, S3, S4, S5, S6, S7, and ...that the degree of spindle elongation correlates with the presence of scattered chromosomes between the spindle ...at ... See full document
18
Functional characterization of a juvenile hormone esterase related gene in the moth Sesamia nonagrioides through RNA interference.
... larvae. The insects were obtained from an established laboratory colony of ...instars. The age of analyzed larvae within each instar was measured in days after the preceding ecdysis, in respect to ... See full document
15
Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway.
... confirm the role of these genes in RNAi ...inhibits the replication of DENV can be triggered in the midgut of transgenic mosquitoes by expression of an inverted repeat RNA (IR-RNA or ... See full document
11
HIV-1 RNAs are Not Part of the Argonaute 2 Associated RNA Interference Pathway in Macrophages.
... to the human and viral genome was applied to avoid false positive hits on the viral ...of the loci harbored the indica- tive T-to-C mutations that are required for excluding background ... See full document
16
Knockdown of E2f1 by RNA interference impairs proliferation of rat cells in vitro
... by RNA interference represents a promis- ing therapeutic ...study, the introduction of specific short hairpin RNAs (shRNAs) reduced E2f1 ex- pression by up to 77%, and impaired rat glioma cell ... See full document
6
Dissecting systemic RNA interference in the red flour beetle Tribolium castaneum: parameters affecting the efficiency of RNAi.
... whether the lack of sequence variety caused the short dsRNAs to be ineffective, we increased the sequence variety by synthesizing a second 31 bp dsRNA and coinjecting the two 31 bp dsRNA ... See full document
14
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
... vitro, RNA interference of RanGAP1 showed no effect on LCL but enhanced DLBCL cell death (41% ...kinases, the central regulators of mitotic cell ... See full document
12
Modulating drug resistance by targeting BCRP/ABCG2 using retrovirus-mediated RNA interference.
... for the reversal of ABC membrane transporter protein family-mediated drug resistance and a scientific basis for targeting the ABC domain by V-BCRPi with high efficiency and ...demonstrated the ... See full document
9
RNA interference and Register Machines (extended abstract)
... which the two registers are realized respectively as the initiator (dsRNA) and the target (mRNA) of ...on the registers represent chemical reactions mediated by en- zymes and proteins ... See full document
6
Strand Analysis, a free online program for the computational identification of the best RNA interference (RNAi) targets based on Gibbs free energy
... are the molecules of choice for RNAi studies because they are too small to trigger such ...to the fact that, intracellularly, siRNAs are incorporated into an RNA-induced silencing complex (RISC) ... See full document
6
Rev. Bras. Reumatol. vol.47 número1
... in the process of RNA interference (RNAi), mRNA degradation and/or mRNA ...in the cell by influencing the fate of ...for the presence of ... See full document
2
Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells
... However, the functional role of PPM1D in bladder cancer (BC) remains largely ...In the present study, lentivirus vectors carrying small hairpin RNA (shRNA) targeting PPM1D were used to explore ... See full document
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