[PDF] Top 20 The TP53 Gene, its Products and Regulation
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The TP53 Gene, its Products and Regulation
... The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently ... See full document
8
Molecular structure and functional analysis of runx3 in zebrafish
... by the three distinct genes, RUNX1, RUNX2 and RUNX3 that share an evolutionarily conserved 128 amino acid Runt domain, which is responsible for the dual function of DNA binding and hetero- ... See full document
243
Regulation of STEAP1 gene and its clinical significance in human prostate cancer
... but the mechanisms underlying its overexpression remain to be ...post-transcriptional and PTM. Considering that both mRNA and protein stability display an important role at cellular level, in ... See full document
224
Presence of new mutations in the TP53 gene in patients with lowrisk syndrome : two case reports
... of the gene were amplified by polymerase chain reaction (PCR) in deoxyribonucleic acid (DNA) extracted from ...leukocytes. The PCR primers and condi- tions for amplification of genomic DNA ... See full document
4
Polimorfismos do gene TP53 no linfoma de Hodgkin
... years-old. The TP53 gene is 20kb length gene with 11 exons that encodes the p53 protein, which main function is related to the conservation and integrity of the ... See full document
85
Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification.
... endogenous and exogenous toxins in mammals. Its Drosophila homolog spineless plays an important role in fly ...CG5017 gene, which encodes a nucleosome assembly factor and may affect cognitive ... See full document
9
Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
... TP53 gene mapped on ...suppressor gene composed by 11 exons ( ∼ 20 KB), which genomic integrity of exons 5–8 is parti- cularly important for its activity [16, ...17]. TP53 gene ... See full document
14
Hormone-mediated gene regulation and bioinformatics: learning one from the other.
... outcome and student’s feedback This activity has been given to 240 students in 4 consecutive academic ...of the bioinformatics tools related to DNA sequence retrieval and ...as the starting ... See full document
4
Análise da expressão imunoistoquímica da proteína p63 e de seu valor prognóstico...
... carcinogenesis and, in this scene, the gene TP53 is one of the most associated with malignant ...to the TP53, were identified, the TP73 and TP63. The ... See full document
174
The hepatic ectonucleotide pyrophosphatase phosphodiesterase 1 gene mRNA abundance is reduced by insulin and induced by dexamethasone
... hepatic gene expressions to maintain metabolic ...determine its potential role in the regulation of metabolism, we analyzed its gene (Enpp1) expression in the liver of ... See full document
9
Expression analysis of the Arabidopsis thaliana AtSpen2 gene, and its
... differentiation, the growth and guidance of axons in the embryo (Chen and Rebay, 2000; Kuang et ...cell-cycle regulation (Lane et al., 2000), and repres- sion of head identity of ... See full document
13
Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands
... for its sequence-specific DNA-binding activity (Cavalcanti Junior et ...2002). The p53 protein is a factor that enhances the transcription rate of a number of known genes that at least partially ... See full document
8
Effects of a silenced gene in Boolean network models
... a gene to ...for the cell. Several techniques exist to eradicate the mutated ...A gene can be cut out from a cell, by recombinant technologies with several methods, which is called the ... See full document
11
International marketing: reentering the chinese salmon market: a case study of Leroy Seafood ASA
... sashimi. The survey’s respondents were 19-30 years, the majority living in urban areas (around 70%), 53% females and 47% males, and all attending higher ...education. The survey states ... See full document
86
Horizontal Gene Transfer and its Detection
... in the evolutionary history of many species (Gurudatta and Corces, 2009; Zhou and Wang, ...is the acquisition of pathogenicity islands in prokaryotic species (Gal-Mor and Finlay, 2006), ... See full document
7
Detecção das proteínas p53, p63 e puma no carcinoma de células escamosas corneal de cães: Lucas Bahdour Cossi. -
... A proteína p53 supressora de tumores, que possui fundamental papel no controle do crescimento e neoplasias, tem sido uma das proteínas mais extensivamente estudadas nos últimos anos e está entre as mais comumente ... See full document
62
Rev. Bras. Hematol. Hemoter. vol.27 número1
... of the TP53 gene and inactivation of the p53 protein are the most common alterations observed in human ...cases. The objective of this study was to evaluate the p53 ... See full document
2
Polimorfismo do gene tp53 no códon 72 em pacientes com suspeita de LMC.
... no gene TP53 são as alterações genéticas mais comuns em tumores malignos ...do TP53 no códon 72 (arginina - Arg e prolina - Pro), em pacientes com suspeita de LMC, pela Reação em Cadeia da ...do ... See full document
5
Avaliação da metilação do gene TP53 e instabilidade genômica em ratos expostos a...
... o gene do fator de crescimento Igf2 (insulin-like growth factor 2), o alelo paterno é expresso, enquanto o inibidor de crescimento Igf2r (insulin-like growth factor 2 receptor) o alelo materno é expresso (JIRTLE; ... See full document
47
Modificadores de penetrância de mutações germinativas no gene TP53 em famílias brasileiras...
... mutations, the majority of TP53 mutations are missense substitutions ...insertions and deletions (9%), nonsense mutations (7%), silent mutations (5%) and other infrequent alterations (Olivier ... See full document
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