[PDF] Top 20 Using genomics for drug discovery in medulloblastoma
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Using genomics for drug discovery in medulloblastoma
... Northcott PA, Shih DJ, Peacock J, Garzia L, Sorana Morrissy A, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, ... See full document
150
Current screening methodologies in drug discovery for selected human diseases
... for drug discovery, dynamic combinatorial chemistry (DCC) is a powerful tool for hit identification and optimization for the discovery of binders to DNA, RNA and protein targets, including biological ... See full document
31
Phenotypic and Target-based Strategies for Drug Discovery in Trypanosomes
... happens in vivo and ultimately provide the best hits, selected for their ability to selectively kill the ...higher. In cell-based assays like the described herein, the concomitant measure of activity and ... See full document
262
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
... discovered in 1909 by the physician ...outbreak in Brazil during the ...(primarily in Central and South America) are infected with ...Hence, discovery of new drugs for treatment of Chagas ... See full document
22
Comparative genomics allowed the identification of drug targets against human fungal pathogens
... expressed in its genome/transcriptome. Subsequently, the presence of these genes in the 2 iso- lates of ...confirmed. Using the isolate Pb01 sequence, released by Broad Institute ...search in ... See full document
10
Computational drug discovery for the Zika virus
... similarity using Tanimoto coefficient and bit ...compared using molecular fingerprints, a high-dimensional sequence of bits that accounts for the absence (0) or presence (1) of representative fragments or ... See full document
10
Metabolomics and Its Potential in Drug Discovery and Development From TCM
... mics in the hypothalamus tissue of yeast-induced pyrexia rats, 0furthermore, the pathophysiology of the disease due to the biochemical changes in the hypothalamus during the febrile response was clarified ... See full document
7
Drug discovery and computational strategies in the multitarget drugs era
... involved in several pathologies such as ...study using common computational techniques, the way they were applied reflects their differential in the search for multi-target ...used in the ... See full document
25
Neural cell models for disease modeling and drug discovery
... immortalized in vitro by transfection of ...occurring in the CNS, as well as the organ-specific structural and functional features (Conti and Cattaneo, 2010; Gupta et ...induced in vitro to ... See full document
204
Yeast cell model in anticancer drug discovery. Microbiologia (Portuguese Society for Microbiology Magazine) Nº 3.
... p53 in yeast induced a marked growth inhibition associated with S-phase cell cycle ...p53 in yeast allowed the development of a yeast phenotypic assay, based on simple measurement of cell growth (Figure ... See full document
8
Three-Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development
... and drug resistance is highly dependent on the biochemical and biophysical cues of its own ...current in vitro disease model’s impasse and this way overcome the lack of predictivity of the most applied ... See full document
45
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information
... involvement in protein anchorage to membranes and transporters. In trypanosomes, several molecules, such as miltefosine and azasterol, have been evaluated as structural analogues of lipids, phospholip- ids ... See full document
11
CURRENT TRENDS IN DRUG DISCOVERY: TARGET IDENTIFICATION TO CLINICAL DEVELOPMENT OF THE DRUG
... the drug discovery process has been revolutionized with the involvement of some newer ...based drug design is more advantageous, time consuming and ...importance in discovering new drug ... See full document
5
Genome-wide discovery of drug-dependent human liver regulatory elements.
... genes, using a p-value cutoff that adjusted for multiple testing less than or equal to ...involved in drug response and the top differentially expressed gene was CYP3A4, fitting with its role as the ... See full document
11
Improving the drug discovery process by using multiple classifier systems
... information. In detail, they allow (i) efficiently manipulating huge amounts of information, (ii) applying unused techniques (due to their high computational requirements) and (iii) implementing new exploratory ... See full document
34
High throughput screening for anti-Trypanosoma cruzi drug discovery.
... counterparts, in terms of growth, cycle stage transitions, mice infection, and in vitro sensitivity to known drugs ...found in chemical libraries, might interfere with the readout when using ... See full document
6
Human cardiomyocytes for drug discovery
... SV40-T, using the Human CD34+ nucleofector kit and the Nucleofec- tor II device, both by Lonza (Basel, Switzerland) following manufac- turer’s ...incubated in MEF-coated plates in MEF medium and FBS ... See full document
9
Natural products as leads in schistosome drug discovery
... [50,51]. In addition, adult worms have the highest level of specific antioxidant enzymes that neutralize reactive oxygen species as compared to schistosomules [52], which may explain why artemisinins are more ... See full document
32
Contribution to drug discovery and development for tauopathies using yeast as a model
... involved in neurodegeneration between yeast and human, further supporting the use of yeast in modelling human ...enrichment in a particular functional category was detected in the functional ... See full document
259
Discovery of cellular proteins required for the early steps of HCV infection using integrative genomics.
... genes in virus proliferation using HCV pseudoparticles that are suitable for testing the entry step of HCV infection ...CD63 in HCV infection was analyzed further ... See full document
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