Amyloid-β
Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.
... Citation: Whitehouse IJ, Brown D, Baybutt H, Diack AB, Kellett KAB, Piccardo P, et al. (2016) Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The ...
10
Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy.
... heterogeneous amyloid-β (Aβ) peptide, varying in length and ...pyroglutamate-modified amyloid-β (pEAβ) peptides have increasingly moved into the focus since they have been described to be the ...
11
Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex
... received amyloid-β or ...performed. Amyloid-β did not change the kinases activity in the hippocampus and cerebral cortex of ...by amyloid-β, but for the cytosolic fraction, it ...
12
Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.
... Importantly, hydrophobic interactions were also found to play crucial roles in the hetero dimerisation process. In a single interaction mode devoid of inter-protein salt bridges, the van der Waals interactions dominated ...
13
Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele.
... reducing amyloid pathology in the brain in the preclinical study and the relationship between amylin and Ab in the context of ApoE allele seen in this human study, pramlintide may have potential as a treatment in ...
7
Brain-derived neurotrophic factor and adenosine signalling on amyloid-β peptide induced toxicity : impact on hippocampal function
... this single fragment was able to recapitulate many hallmarks of AD, such as progressive neuronal loss in cortex and hippocampus, forebrain atrophy, tau pathology, amyloid plaques, intraneuronal Aβ accumulation, ...
157
Amyloid β levels in human red blood cells.
... Measurement of Ab40 and Ab42 in RBCs and Plasma For determination of Ab40 and Ab42 in RBCs, human b Amyloid (1–40) ELISA kits (WAKO, Osaka, Japan) and human b Amyloid (1–42) ELISA kits (WAKO) were used, ...
6
Apoptosis signaling associated with amyloid β-induced cellular dysfunction and degeneration : relevance for Alzheimer’s disease
... Of the several mutations identified in the APP gene, substitutions at residues flanking the Aβ region affect the rate of enzymatic APP processing and the production of Aβ42, resulting in an early-onset AD phenotype ...
184
Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice.
... Moderate to severe traumatic brain injury (TBI) can accelerate cognitive decline and increases the risk of dementia of the Alzheimer’s type [1,2,3,4,5]. Alzheimer’s disease (AD) is charac- terized by several pathological ...
8
Effects of ligands on unfolding of the amyloid β-peptide central helix: mechanistic insights from molecular dynamics simulations.
... the amyloid cascade hypothesis [1,2,3], accumulation of the amyloid b-peptide (Ab) in the brain is the primary influence driving AD ...the amyloid precursor protein ...
13
Cognition and memory function of Taraxacum coreanum in an in vivo amyloid-β-induced mouse model of Alzheimer’s disease
... AD is the most common cause of progressive cogni- tive decline and dementia in aged humans (Meziane et al., 1998). Although the causes of AD are not well known, one widely discussed hypothesis is that de- posits of Aβ ...
10
Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.
... The Ca 2+ hypothesis, which introduced the concept of regulation by Ca 2+ of neuronal death both in age-related and in pathogenic processes, attempts to explain how disruptions in Ca 2+ homeostasis that continue over a ...
10
Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.
... Phenserine treatment increased cortical synaptophysin levels in younger mice, while decreased interleukin-1 b and increased monocyte chemoattractant protein-1 and tumor necrosis factor-a[r] ...
11
Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice.
... of amyloid-b into neurotoxic oligomers and ...inhibits amyloid-b aggregation and ameliorates the disorder has not been approved to ...disrupts amyloid-b oligomerization, preserving cognitive behavior ...
10
Alzheimer's-related peptide amyloid-β plays a conserved role in angiogenesis.
... of Amyloid-b (Ab). Early versions of the amyloid hypothesis considered Ab something of an undesirable byproduct of APP processing that wreaks havoc on the human neocortex, yet evolutionary conservation - ...
8
Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells.
... elevated amyloid-b peptide (Ab) and loss of nicotinic acetylcholine receptors (nAChRs) being prominent ...Extracellular amyloid plaques, predominantly consisting of Ab, and intracellular neurofibrillar ...
9
Amyloid β peptide and p63 : two prime triggers of neural apoptosis and differentiation
... p63 is a close relative of the p53 tumor suppressor and transcription factor that modulates cell fate. The full-length isoform of p63, containing a transactivation (TA) domain (TAp63) is an essential proapoptotic protein ...
171
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology
... Three indexes were calculated in order to evaluate both preference between objects and recognition of the novel object: 1) the object preference index, which is the ratio between the tim[r] ...
15
Undetectable Levels of CSF Amyloid-β Peptide in a Patient with 17β-Hydroxysteroid Dehydrogenase Deficiency
... Although this protein has been genetically implicated in Alzheimer’s disease pathogenesis, studies of amyloid-  peptide (A) in patients with HSD10 deficiency have not been previously reported. We found, in a ...
7
Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.
... Natural amyloid-beta oligomer and control solutions A solution containing natural amyloid-beta (Abeta) oligomers was derived from the conditioned medium of 7PA2 cells (a kind gift of ...an amyloid ...
7