Mitogen-activated protein kinases
Roles of mitogen-activated protein kinases and angiotensin II in renal development
... mice. Mitogen-activated protein kinases (MAPKs) are important mediators that transduce extracellular stimuli to intracellular ...signal-regulated protein kinase (ERK), c-jun N-terminal ...
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Evolutionary history of the vertebrate mitogen activated protein kinases family.
... the protein sequences of the MAPK family using PHYML ...MAPK protein sequences from mammals, amphibians/reptiles and teleosts are marked in blue, green and red, ...
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Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages.
... function. Protein tyrosine phosphatase non-receptor type 7 (PTPN7), a member of the phosphatase family, specifically inactivates mitogen-activated protein kinases ...
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Increased expression of p38 mitogen- activated protein kinase is related to the acute renal lesions induced by gentamicin
... Figure 1. Immunolocalization of p-p38 MAPK in the renal cortex (A, C and E) and in Masson’s trichrome-stained histological sections (B, D and F) from rats killed 5 days after treatment with NaCl (A and B), gentamicin (C ...
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O circuito p38MAPK/MSK1 influencia o período inicial de diferenciação Th1/2
... As vias de sinalização MAPKs (do inglês mitogen-activated protein kinases) conectam os receptores de superfície celular aos elementos regulatórios das células. MAPKs podem ser ativadas em ...
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The Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) Pathway.
... comparatively increased levels of ROS as compared to untreated cells, increase being 1.3 (P<0.001), 2.0 (P<0.001) and 1.7 (P<0.001) fold for WT, ΔSlt2 and ΔHog1 strains respectively after Rohitukine treatment as ...
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Genome-wide identification and analysis of expression profiles of maize mitogen-activated protein kinase kinase kinase.
... full protein sequences of all MAPKKKs, we found that the most of the Raf group proteins had a C-terminal kinase domain and extended N-terminal ...family protein were located either at N- or C-terminal or ...
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p38 Mitogen-Activated Protein Kinase Pathway Regulates Genes during Proliferation and Differentiation in Oligodendrocytes.
... ine/threonine-protein kinases Bub1 (budding uninhibited by benzimidazoles 1 homolog) and a related isoform, ...a protein involved in vesicular transport were downregulated after PD169316 treatment ...
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Elevation of Ca 2+ mimics Ang II in MAPKERK activation
... the mitogen-activated protein kinase (MAPK) such as extracellular signal-regulated kinase (ERK 1/2) have been reported, even though the pathway leading to ERK activation is, in many cases, mediated ...
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Effects of lipopolysaccharide on low- and high-density cultured rabbit vascular smooth muscle cells: differential modulation of nitric oxide release, ERK1ERK2 MAP kinase activity, protein tyrosine phosphatase activity, and DNA synthesis
... on protein tyrosine phosphatase (PTP) and ERK1/ERK2 mitogen-activated protein (MAP) kinase ...MAP kinases was maximal at 12 min in non-confluent RVSMC and was prevented by preincuba- ...
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An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion.
... example, ERK MAPK is involved in thrombus formation. In contrast to results using p38 MAPK inhibitors, the inhibition of ERK did not influence PLT mitochondrial function or any structural, metabolic or functional ...
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Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs.
... Animals were given 30 mg/kg intraperitoneally of the dual p38 and JNK MAPK inhibitors V-05-013, V-05-014, or V-05-015 (Vertex Pharmaceuticals, Cambridge, MA) one hour before ozone exposure (Figure 1). These compounds ...
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Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling.
... pathways have also been implicated in control of amino acid [36– 38] and glucose [24,25] utilization in other cell types. We therefore tested the importance of ERK and p38 in the control of glucose metabolism during T ...
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Rational design of protein kinase inhibitors
... All active flavone inhibitors have a similar type of binding. In all obtained «CK2–inhibitor» complexes the hydrophobic contacts were formed between the ligand and seven aminoacid residues (Leu45, Val53, Val66, Ile 95, ...
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Survey of activated FLT3 signaling in leukemia.
... Since FLT3 is also involved in the pathogenesis of B cell acute lymphoblastic leukemia (B-ALL), we investigated FLT3 tyrosine signaling in three B-ALL cell lines, SEM, RS(4;11) and REH. While SEM cells express high level ...
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Identification of Differentially Expressed Genes Related to Dehydration Resistance in a Highly Drought-Tolerant Pear, Pyrus betulaefolia, as through RNA-Seq.
... To validate the reliability of the drought responsive gene expression profiles for DEG, 16 genes were confirmed by quantitative real-time PCR using gene-specific primers (S11 File). These selected genes encoded dehydrin ...
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Adenosine A(2A) Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by beta-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway
... a protein located in synaptic vesicles (Masliah and Terry, ...acidic protein (GFAP) (a marker of astrocytes) (Pekny and Nilsson, 2005) was performed to evaluated microgliosis and astrogliosis, ...
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Non-degradative Ubiquitination of Protein Kinases.
... all protein families [62,63], and Duttler et ...nascent protein chains also is not enriched in regions of intrinsic disorder ...on kinases, we found that ubiquitination occurs outside folded domains ...
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Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- and Rho kinase-dependent manner
... min for p.IκB, 10 min for NF-κB, p.NF-κB, and p.STAT3 or 15 min for p.JNK and p.p38), cells were lysed and lysates were assayed for protein content. Signaling mediators in cell lysates were measured using a ...
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Conservation, variability and the modeling of active protein kinases.
... The only other variability we have found in conserved residues is for the so-called catalytic lysine (lysine 8). The function of this residue is somewhat debated [17,18,19], but at the very least it appears to position ...
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