[PDF] Top 20 The PGE(2)/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection
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The PGE(2)/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection
... In the present study, we demonstrate that phagocytes derived from B-1 cells (called B- 1CDP) have the ability to phagocytose the pathogenic protozoan parasite ...L. major. Moreover, ... See full document
18
Automated Nuclear Analysis of Leishmania major Telomeric Clusters Reveals Changes in Their Organization during the Parasite's Life Cycle
... treated the cells with proteinase K before fixation, we obtained an average of 30 telomere spots per nuclei ...L. major telomeres are in clusters brought together through protein ...L. major has 72 ... See full document
7
Inhibition of caspase-8 activity reduces IFN-γ expression by T cells from
... upon infection) were cultured in 48 well plates with plate bound anti-CD3 (10 µg/mL) in the presence or absence of IL-4 (1 ng/mL), zIETD (40 µM) or ...added to all ... See full document
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Rev. Soc. Bras. Med. Trop. vol.45 número1
... of the present study was to identify the presence of Leishmania (Leishmania) chagasi infection in dogs in the City of Palmas, Tocantins, Brazil, using the PCR ... See full document
6
Peripheral blood fibrocytes: new information to explain the dynamics of Leishmania infection
... by the co-expression of leukocyte cell surface mol- ecules, CD45 or CD14 and extracellular matrix proteins, such as collagen type I and type III (Bucala et ...addition to these markers, fibrocytes may ... See full document
9
IFN-γ production to leishmania antigen supplements the leishmania skin test in identifying exposure to L. braziliensis infection.
... for the skin test was prepared with an isolate of ...urine. The promastigotes were washed in sterile phosphate buffered saline (PBS), resuspended in lysis solution (Tris HCl, EDTA and leupeptin), immersed ... See full document
8
Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.
... of the host ...exposure to the parasite, become silenced when the infection is firmly established, rendering the cell unresponsive to further stimulation with LPS ... See full document
15
SPECIES IN THE INFECTION CAUSED BY LEISHMANIA AMAZONENSIS: IMPLICATIONS RELATIVE TO THE SITE OF INFECTION
... patrol the postcapillary venules, through temporary interactions, via rolling in endothelial cells, surveying connective tissue, mucosal membranes, skeletal muscle, and lymphatic organs for signs of tissue damage, ... See full document
197
Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response.
... using the TriFast reagent (Peqlab, Erlangen, Germany) and contaminating DNA was removed with DNase I (Ambion DNAfree, Invitrogen, Karlsruhe, ...using the High Capacity cDNA Reverse Transcription Kit ... See full document
12
Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.
... compared to WT (Fig 2A), suggesting that some PG-containing molecules actually inhibit IL12 ...Compared to LPG, little is known about the function of PPGs on host cell immune ...illustrating ... See full document
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Nadja MF Lima, Clariane S Correia, Leonor L Leon, Gérzia MC Machado, Maria de Fátima Madeira, Antônio Euzébio G Santana, Marília OF Goulart
... of the major infectious diseases affecting the poorest regions of the ...with Leishmania protozoan parasites, transmitted by the bite of a sand fly, cause visceral, cutaneous or ... See full document
6
Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
... of Leishmania-host interaction is the acti- vation of macrophage’s antimicrobial ...with Leishmania contributed de- cisively to identify phagocyte oxidase (phox) and especially nitric oxide ... See full document
12
Neutrophils Contribute to the Protection Conferred by ArtinM against Intracellular Pathogens: A Study on Leishmania major.
... by the observation that neu- trophils treated with NADPH oxidase, a pharmacological inhibitor of ROS production, do not form NET in response to conventional stimuli ...L. major, did not form NET. ... See full document
23
Leishmania major: Parasite Interactions Suggesting Sexuality
... experiments, Leishmania (Leishmania) major (MRHO/SU/59/P-strain) grew poorly when seeded in FYTS medium supplemented with 15% fetal calf serum, but presented several peculiar pairs of promastigotes ... See full document
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Rev. Soc. Bras. Med. Trop. vol.48 número5
... with Leishmania infections, and it is only after the failure of these treatments that the patients are suspected of having ...cases, the ability to examine paraffi n-embedded tissues for ... See full document
5
Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response
... ability to control the establishment of the immune response in ...between the nucleotide hydro- lytic activity and the severity of the clinical manifestation was also observed ... See full document
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Utilização de Kluyveromyces lactis na expressão da GDPase de Leishmania major.
... The yeast Kluyveromyces lactis has a potential applicability as a host in biotechnological production of heterologous recombinant proteins of biotechnological ...context the objective of this work was ... See full document
79
Immune modulating effects of NKT cells in a physiologically low dose Leishmania major infection model after αGalCer analog PBS57 stimulation.
... Leishmaniasis is a parasitic disease which is caused by a variety of Leishmania spp. and affects about 12 million people worldwide. There are approximately 2 million people newly infected every year. Transmitted ... See full document
11
Comparative Two-Dimensional Gel Electrophoresis Maps for Promastigotes of Leishmania amazonensis and Leishmania major
... L. major are shown in Figure ...editing to correct for artifacts (see Material and Methods), the image analysis confidently detected approximately 1,650 spots for ...L. major (Figure 1B), ... See full document
6
Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALBc mice
... - To evaluate the effect of PEM on the parasite load, spleens and livers were collected and weighed ...collected to be used for parasite quanti- ...burden. The number of parasites was ... See full document
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