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[PDF] Top 20 Development of New Peptide-Drug Conjugates for Cancer Therapy

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Development of New Peptide-Drug Conjugates for Cancer Therapy

Development of New Peptide-Drug Conjugates for Cancer Therapy

... and Drug Administration, USA) como opção terapêutica de primeira linha para doentes com adenocarcinoma pancreático localmente avançado (inoperável, fase II ou II) ou metastático (fase IV) previamente tratados com ... See full document

124

Towards determining the structure of human KIFC1, a potential target for drug development in cancer therapy

Towards determining the structure of human KIFC1, a potential target for drug development in cancer therapy

... specially of surface residues, hoping the new protein will crystallize (Chayen and Saridakis, 2008; Derewenda, 2011; McPherson and Gavira, ...tool of the NCBI website, between the crystallized ... See full document

85

Natural products as new antimitotic compounds for anticancer drug development

Natural products as new antimitotic compounds for anticancer drug development

... antimitotic therapy is that not all cells blocked in M phase will die, with many becoming ...quence of chromosomal instability, that is, susceptibility to the gain and/or loss of chromosomes, which ... See full document

11

Development of nanoparticles incorporating a novel liposomal membrane destabilization peptide for efficient release of cargos into cancer cells.

Development of nanoparticles incorporating a novel liposomal membrane destabilization peptide for efficient release of cargos into cancer cells.

... In cancer therapy, a drug delivery system (DDS) that can specifically deliver various therapeutic agents to tumor tissue is a powerful tool for achieving cancer cell-specific therapy ... See full document

11

Design and development of novel magnetic lipid nanoparticles for anti-cancer therapy

Design and development of novel magnetic lipid nanoparticles for anti-cancer therapy

... reports of successful paclitaxel-loaded NLC formulations are staggeringly ...As of the time of writing, the author could only locate five divulged papers on the subject [56, 89-92], three written by ... See full document

57

Expression of aquaporins in pancreatic tumors: new targets for cancer therapy?

Expression of aquaporins in pancreatic tumors: new targets for cancer therapy?

... complexity of AQP5 therapeutic use is further illustrated by its involvement in both chemosensitivity and drug-resistance mechanisms in ...need of a tissue-targeted approach for anticancer treatment. ... See full document

62

Development of multifunctional composite aerosols for lung cancer therapy

Development of multifunctional composite aerosols for lung cancer therapy

... aerosol of a suitable size (1-5 μm), with a reproducible drug dosing ensuring that both chemical stability and activity of the drug are maintained ...the drug is dissolved in a polar ... See full document

94

Study of new therapeutic strategies to combat breast cancer using drug combinations

Study of new therapeutic strategies to combat breast cancer using drug combinations

... ideal drug is one that selectively kills the neoplastic cells, minimizing adverse ...activation of signaling pathways. Therefore, pharmacotherapy of cancer is difficult to achieve in a totally ... See full document

23

Development of new DODAX:MO:DC-Chol nanoparticles containing BRAF-siRNA for colorectal cancer therapy

Development of new DODAX:MO:DC-Chol nanoparticles containing BRAF-siRNA for colorectal cancer therapy

... best of our knowledge, no BRAF specific drug has been ...Gene therapy, through RNAi machinery, is a reliable alternative to the conventional cytotoxic drugs used currently in a combination regime in ... See full document

91

Development of a new drug delivery system for future application in cancer therapy

Development of a new drug delivery system for future application in cancer therapy

... gene therapy has become a promising alternative for the treatment of many incurable diseases such as ...most of the generally used treatments rather ...advantage of novel non-viral gene ... See full document

89

Perspectives of Dendrimer-based Nanoparticles in Cancer Therapy

Perspectives of Dendrimer-based Nanoparticles in Cancer Therapy

... Currently, cancer is the second most common cause of death in the United States, exceeded only by heart ...fraction of the drug reaching the tumor, in this sense, the use of dendrimers ... See full document

16

Pharmaceutical development: galenical development of a generic drug product

Pharmaceutical development: galenical development of a generic drug product

... one of the most competitive environments, the creation of unrealistic timelines, generally contributes for the unsatisfaction of the intervenients as well as the ...point of the ... See full document

77

Development of a Proliposome Formulation as a Drug Carrier for a Novel Antitumor Drug

Development of a Proliposome Formulation as a Drug Carrier for a Novel Antitumor Drug

... motion of particles suspended in a fluid, and thus the distance between the scatters in the solution is constantly changing with time (Figure ...intensity of scattered ...motion of particles, and ... See full document

107

Modulating the structure of EGFR with UV light: new possibilities in cancer therapy.

Modulating the structure of EGFR with UV light: new possibilities in cancer therapy.

... potential of EGFR overexpressing ...evasion of colon cancer cells from stimulation of epidermal growth factor ...inhibition of cell survival and proliferation, concurrently inducing the ... See full document

15

Cancer gene therapy

Cancer gene therapy

... backbone of nucleic acids and condense/compacts them spontaneously into nano-sized ...ability of RALA to strongly bind, interact and consequently condense the DNA has been widely recognized and explored to ... See full document

86

Cellulose nanofibril-cell adhesive peptide conjugates for 3D printed skin tissue model

Cellulose nanofibril-cell adhesive peptide conjugates for 3D printed skin tissue model

... simplicity of use and effectiveness of coverage and protection of the wound ...amounts of exudate, which may hinder the wound healing process by not providing a moist environment, representing ... See full document

66

Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach

Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach

... coating of the AuNPs, whereas BTZ** species are predominantly adsorbed on the surface of ...locations of BTZ* and BTZ** with respect to the PEGAuNPs structure could explain the decrease of the ... See full document

12

THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.

THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.

... preparation of glutaminase obtained from both kidney and intestine mitochondria (data not ...grade of inhibition on a cell culture based method, using the neutral red (NR) ...Effects of selected ... See full document

8

In vitro comparative studies on new targets for cancer therapy, and characterization of their biomolecular effects

In vitro comparative studies on new targets for cancer therapy, and characterization of their biomolecular effects

... consist of stacked G- tetrads (or ...bonding of the double-helix model (Yang & Okamoto, ...cavities of the stacks and are coordinated by the strong negative electrostatic potential of ... See full document

56

Action of new porphyrin conjugates with potential anti-malaria activity on membranes

Action of new porphyrin conjugates with potential anti-malaria activity on membranes

... process of collision, in the presence of an inert gas, part of the energy of the precursor ion may be converted into internal energy, promoting an exciting state on ions, which are fragmented ... See full document

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