[PDF] Top 20 Experimental infection of Leishmania chagasi in immunosuppressed balb/c mice: cellular immune response and parasite burden

... The immune response to leishmaniasis can result in a polarization of a subpopulation of T lymphocytes, which leads to a different cell phenotype and results in ... See full document

... recovery in the brain and greater survival rate when compared to other strains (Strube et ...use in the present assay. Infection of BALB/c mice with ...type ... See full document

... effects of malnutrition on the parasite load, this parameter was evaluated in the liver and ...increase in parasite load per liver in infected mice but no increase ... See full document

... many of the features of infection seen in immunocompetent mice, we then went on to explore how well we could recapitulate the differing outcomes of infection as seen ... See full document

... versatility of our model for future drug studies, we treated infected humanized mice and BALB/c mice with ...Miltefosine. In BALB/c mice the ... See full document

... production of chemokines by infected peritoneal macrophages was evaluated, a higher production of CXCL10 by cells infected with long-term cultured parasites was observed ...important in the ... See full document

... C57BL/6 mice, but not in WT mice (unpublished ...resulting in macrophage recruitment and activation, and are indicative of protective cell-mediated immune responses ... See full document

... Determination of tissue parasite burden - To evaluate the effect of PEM on the parasite load, spleens and livers were collected and weighed ...for parasite quanti- ... See full document

... Complement-depleted and -non-depleted BALB/c mice were inocu- lated with Leishmania (Leishmania) amazonensis promastigotes into the hind footpad to study the role of the ... See full document

... one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lympho- ...role in humoral and cellular immune ... See full document

... detection of IL-10-inducing ...cloned and expressed and theoretically used, similarly to Th2-induc- ing antigens, in immunization protocols that offset their ability to induce ...constraint ... See full document

... incidence in Brazil. In the Latin America, one of its classic and serious forms of the disease, visceral leishmaniasis (VL), is caused by the Leishmania chagasi ... See full document

... demonstrated in the murine model of cutaneous leishmaniasis caused by ...1989). In contrast, a similar pattern of T-helper cell subsets has not been demonstrated in vis- ceral ...Wilson ... See full document

... lower in the immunosuppressed group than in the control and uninfected groups at the end of immunosuppressive treatment suggests that immunosuppression caused by dexamethasone until day ... See full document

... The immune response in leishmaniasis may result in a polarization of the T lymphocyte subpopulation, altering cell phenotype and resulting in immune protection or ... See full document

... models of infection with Leishmania ...knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite ...exists, and ... See full document

... variation of the hot plate (HP) and tail flick (TF) tests used in other studies (Kanaan et ...2006) and was adapted by our group to detect heat-evoked nociception-related behaviour in ... See full document

... Immunophenotyping of peripheral blood by flow cytometry was performed as described by Reis et ...lysed in 1 mL EDTA-treated whole blood by the slow addition of 13 mL fluorescence-acti- vated cell ... See full document

... included in this study were potentially exposed to Leishmania infection since they came from endemic areas with epidemiological evidences of para- site transmission (Oliveira-Neto et ... See full document

... protozoan infection in immuno- compromised ...development of an experimental E n c e p h a l i t o z o o n cuniculi infection in the central nervous system of ... See full document