[PDF] Top 20 Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients

... study of European normal glucose-tolerant individuals who were first- degree relatives of type 2 diabetic patients and well-matched with the control ... See full document

... yperglycemia and type 2 diabetes are caused by insulin resistance and beta-cell ...genetic and en- vironmental factors, including inlammation and stress agents, such as ... See full document

... direct secretion of insulin from beta cells, while the autonomic nervous system regulates glucose concen- trations in the ...body. Diabetic autonomic neuropathy, which includes cardiac ... See full document

... aetiology and pathogenesis of diabetes (ADA, 1997; Genuth et ...forms of diabetes. Type 1 diabetes involves the autoimmune-mediated failure or destruction of pancreatic –cell islets, ... See full document

... role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/ − 9 polymorphism was associated to the transcriptional activity of the ...receptor. In this scenario, ... See full document

... increase in serum insulin levels in response to a glucose challenge, suggesting a role for KSR1 in insulin ...regulator of KSR1. Mice lacking MARK2 have an increased rate ... See full document

... weight, and waist circumference were ...AM and 10:00 AM after an overnight ...4°C and stored at –80°C until as- ...Free and bioavailable testosterone values were calculated from total ... See full document

... As in other studies, the present data regarding family history were ...This type of data is susceptible to bias, because patients may remember more facts about their mothers than about their ... See full document

... Fifty-seven type 2 diabetic patients with metabolic syndrome and on insulin were assessed by a paired analysis before and 6 months after addition of metformin as ... See full document

... predictor of diabetes, metabolic syndrome, and cardiovascular disease ...ratio of diabetes in subjects with high LAP was ...10.75) and 19.09 (95% CI, 6.57 to 55.50) in Japanese ... See full document

... prevalence of diabetes is estimated to be ...people, of whom 5 to 10% have type 1 of the disease ...these patients took place approximately 20 years ago with the emergence of ... See full document

... hyperinsulinemia and hypertension are common features of animal models of insulin resistance induced by a high-fructose diet ...hypertension in rats was related to the changes in ... See full document

... increased insulin sensitivity in individuals with NF1 are ...role in the development of ...Pal and cols. (25) demonstrated that patients with mutations in the tumor ... See full document

... volunteer patients with type-2 diabetes mellitus were recruited from the outpatient services of the Hospital das Clínicas Heart Institute of the University of São Paulo Medical ... See full document

... safety and efficacy ...effects of the interventions, analyses of changes from baseline to week 12 of metabolic or body composition parameters included only subjects with complete data at both ... See full document

... mg/kg) and performed an oral glucose tolerance ...administration of GKA23 reduced glucose levels in the fasting state (0 minute, ...than in vehicle-treated animals, but the ... See full document

... commitment of mesenchymal stem cells into preadipocytes ...regulation and sub- sequent commitment to adipocyte differentiation 9 ...cells and ADSCs treated with recombinant BMP4 showed increased ... See full document

... IRS and T2DM, individuals were enrolled at an earlier stage in the progression of dis- ease when compared with other prevention ...level of physical activity, both groups had marked low ... See full document

... absence of a hypoglycemic effect for the date seed extract when administered to normoglycemic ...high in date seed extract-insulin-treated diabetic rats (group IV) when compared to those ... See full document

... hyperglycemia, diabetic dyslipidemia, and he- patic steatosis. The aim of the current study is to determine the temporal relationships be- tween the development of hepatic steatosis ... See full document