[PDF] Top 20 A new and potent class of quinoline derivatives against cancer
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A new and potent class of quinoline derivatives against cancer
... million of deaths worldwide [1]. This disease accounted for nearly one-quarter of all deaths in the United States in 2012, exceeded only by heart diseases ...years of rapid advances in the ... See full document
12
Induction of G2M arrest, caspase activation and apoptosis by asantonin derivatives in HL60 cells
... modeling and combinatorial chemistry, the search for novel anticancer drugs from natural and non-natural sources has continued through the collaboration of scientists worldwide in looking for ... See full document
9
Rev. bras. farmacogn. vol.27 número5
... life, and provide tem- porary relief from symptoms and occasionally complete ...incapacitate cancer cells while having reduced toxicity toward normal tissues (Sharma et ...DK and PTB showed ... See full document
7
Design, synthesis and biological evaluation of (E)2(2)quinoxalines, a promising and potent new class of anticancer agents
... thesized and evaluated for their activity against four cancer cell lines: potent cytotoxicities were found (IC 50 ranging from ...positions and the type of substituents attached ... See full document
6
In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis
... method of drug discovery involves the inves- tigation of natural products obtained from medicinal plants (Braña et ...sources of bioactive substances that are po- tentially useful in the treatment ... See full document
7
Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives
... studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in ...better new photosensitizers. Several ones were developed, evaluated and a few ... See full document
34
J. Braz. Chem. Soc. vol.21 número5
... light of the above reports and because of the potent biological activities of quinoline ring system and 2-substituted benzo[b]furan derivatives, we felt that there ... See full document
19
Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive
... effect of a new class of quinoline derivatives (a-d) on assays in ...peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant ... See full document
11
Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
... important class of compounds of both natural and synthetic ...useful and diverse pharmaceutical and biological activities, and there has been a growing interest in their ... See full document
6
Biological evaluation of isoniazid derivatives as an anticancer class
... series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from ...positions, ... See full document
8
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
... prostate and renal cancers, as well as cell lines established from human melanoma, pleuramesothelioma and the uteri ...K252c and arcyriaflavin A were isolated from actinomycete strain Z2039-2, ... See full document
21
Have preferences of girls changed almost 3 years after the much debated start of the HPV vaccination program in The Netherlands? A discrete choice experiment.
... consisted of the following attributes: 1) the degree of protection against cervical cancer; 2) the duration of protection; 3) the risk of mild side-effects; 4) the age of ... See full document
7
based chalcone hybrids and derivatives : synthesis and potent activity against cancer cell lines
... promising against HL-60 aer assaying these structures against peripheral blood mono- nuclear cells ...efficiency of the compounds in cancer cells with low cytotoxicity in normal cell lines is ... See full document
11
Mefloquine–Oxazolidine derivatives : a new class of anticancer agents
... HO and MeO, or electron-rich heteroaryl groups, for example imidazol-2-yl, can be considered as useful leads for the rational design of new antitumor compounds, as these are more active than MQ ... See full document
6
Synthesis and biological evaluation of mono and bis-naphthalimide derivatives against SH-SY5Y, human brain cancer cells
... for new anticancer drugs and the development of new molecules able to bind to DNA and show anticancer activity has received great attention ...one of the most important ... See full document
169
Synthesis of 2,3Diyne1,4 derivatives and evaluation of cytotoxic activity against tumor cell lines
... a potent cytotoxic agent. Although the excellent cytotoxicity in cancer cell lines, all the compounds presented high inhibitory effect in peripheral blood mononuclear cells, which means non-selectivity ... See full document
7
Simultaneous Determination Of Adjusted Ranks Of Sample Observations And Their Sums And Products
... sums of squares of ranks are different depending on whether or not there are tied observations in the data and hence are assigned mean ...some of the observations are tied and hence ... See full document
7
Chemical and Biological Evaluation of Essential Oils from Two Species of Myrtaceae - Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel
... mL of YEPD (yeast), LB (Gram negative) and BHI (Gram positive) ...milliliters of liquid cultures were grown at 30 °C with aeration (150 rpm) overnight on YEPD (yeast), LB (Gram-negative) or BHI (Gram ... See full document
11
Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei
... potency and selectivity that warranted additional characterization (Table ...effects of BNIPs in host cells, a set of in vitro assays was performed in hepatocytes and neuronal primary ... See full document
10
In our continuing search for bioactive substances,
... (DMSO) and then adding dechlorinated water, to give a solution ...mL of the molluscicide sus- pension at four appropriate concentrations (1000, 100, 10 and 1 ...temperature, and were kept un- ... See full document
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