[PDF] Top 20 Phosphorylation of CFTR and other membrane proteins: a role in biogenesis and traffic?
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Phosphorylation of CFTR and other membrane proteins: a role in biogenesis and traffic?
... wt- CFTR G m and iodide ...III.14 and III.15). Interestingly, T1471A-CFTR is fully processed (Luz, 2008), suggesting that this mutation causes an impairment in channel ...the ... See full document
101
Study of CFTR delivery and stabilization at the plasma membrane
... scope of this ...set of proteins functioning as an actin nucleator, required for actin filament ...Among other proteins, it is regulated by Cortactin, a highly modular protein known to ... See full document
80
Use of fluorescent probes to follow membrane traffic in nerve terminals
... Jr. and Rahamimoff (10) demon- strated a non-linear dependence of the exci- tatory post-synaptic potential on the external calcium ...action of four calcium ions is necessary to stimulate quantal ... See full document
10
New molecular partners involved in the pathophysiology of cystic fibrosis:a role in the biogenesis, processing and trafficking of CFTR
... mechanisms and the molecular partners involved in CFTR biogenesis, intracellular localization, trafficking and function, many processes are not fully ...kinases and phosphatases ... See full document
168
Molecular switches in CFTR processing and trafficking: the role of the novel interactor Rap1A
... itself, CFTR also regulates other channels in the cell ...changes in CFTR itself from those that are consequences of altered chloride ...Regulation of the epithelial ... See full document
65
The role of Helicobacter pylori outer membrane proteins in adherence and pathogenesis
... promotes in vitro IL-8 secretion in a T4SS-independent manner and heightens gastric inflammation in vivo ...PI3K/Akt and this regulation is dependent on FoxO1/3a inactivation ...the ... See full document
25
The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression
... Members of the RAS superfamily of small GTPases are master regulators of all the steps involved in membrane ...many of them are hijacked by cancer cells to enhance their capacity ... See full document
13
CFTR trafficking and membrane anchoring: the role of cAMP signalling
... degree of co-localization under these conditions was near 0.5, these proteins can still interact with each ...with CFTR even if this chloride channel is not at the PM, in early stages ... See full document
116
Biogenesis of peroxisomal intrinsic membrane proteins: unveiling the role of pex19p.
... an in vitro import system was developed to characterize the specific targeting and insertion of a PMP into the peroxisome ...kind of systems has the advantage of being experimentally ... See full document
93
Functional characterization of proteins interacting or modulating CFTR and ENaC traffic and activity
... annexins in regulating ion channels and in particular annexin A5 (AnxA5) in the traffic of the cystic fibrosis transmembrane conductance regulator ...(CFTR). In the ... See full document
173
The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity
... the phosphorylation of NT17 at any of its three phosphorylatable residues completely abolishes mutant Htt aggregation and alters its oligomerization pattern (Figure 9A and Figure 10, ... See full document
72
Functional income distribution in portugal: the role of financialisation and other related determinants
... increase in top management salaries together with a rise in the profit demands of ...emergence of a new design of corporate governance (“shareholder value orientation”) (Crotty 1990; ... See full document
38
In silico simulation of reversible and irreversible swelling of mitochondria: The role of membrane rigidity
... analysis of any real biological systems requires certain ap- proximations that do not take into consideration all of the available factors and ...(event), in particular, our model does not ... See full document
11
Functional income distribution in portugal: the role of financialisation and other related determinants
... increase in recessions and decrease in times of recovery (Dünhaupt 2013a and ...behaviour of the labour share: wages are sluggish; firms delay employment adjustments due to the ... See full document
37
Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells.
... polarity and peripheral actin cytoskeleton pattern appear preserved upon 10 μM wiskostatin or 10 μM L141 treatments compared to vehicle treatment, whereas actin is scattered throughout the cytoplasm with 100 μM ... See full document
23
The role of Cks proteins in apoptosis
... involved in cell cycle arrest, transcriptional induction of repair genes, inhibition of late replication origin firing, and stabilization of stalled replication forks ...phosphorylated ... See full document
63
Role of RHBDD2 in membrane trafficking regulation
... studied in vitro or in detergent-containing solutions, conditions under which only fully assembled complexes ...However, in vivo, when the v- and t-SNARE proteins are anchored in ... See full document
76
Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis.
... F-actin and microtubules, we examine the precise localization of SEPT6 and ...[35,36] and to decorate actin filaments (85% of colocalization) ...(48.9% of AP-3-positive ... See full document
12
Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells
... Chromatin proteins play a role in the organization and functions of ...modifications of nuclear proteins modulate their interactions with DNA sequences and are ... See full document
7
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
... physical and cognitive) later in life, thereby confirming the compression of morbidity hypothesis proposed by Fries in 1980 (Fries, 1980; Hitt et ...performed in centenarians revealed ... See full document
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