[PDF] Top 20 Regulation of the alternative polyadenylation in T cells
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Regulation of the alternative polyadenylation in T cells
... with the pre-mRNA molecules in the nucleus, and can assist in the correct mRNA processing, nuclear export and ...processing regulation (review in [86]), such as hnRNP F, L ... See full document
71
Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.
... with the colori- metric substrate Suc-VPF-pNA to quantify CatG activity between T1D and control ...elevated in T1D-derived PBMC (Fig. 1A). These findings were confirmed with the activity-based probe ... See full document
10
Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels
... features of physiological mRNAs can render them ...expressed in the liver that, when mutated, can cause hereditary hemochromatosis, a common genetic disorder of iron ...metabolism. The ... See full document
12
A comprehensive analysis of core polyadenylation sequences and regulation by microRNAs in a set of cancer predisposition genes
... downregulated in colon, colorectal, and lung tumors ...effectors in tumor suppression, including mir-128, mir- 1471, mir-483, mir-3170 and ...corroborate the assigned role to some of these ... See full document
43
homeostasis of the IL-2-producing CD4 T cells and theirrole in the control of T regulatory cells function and number.
... Treg cells exhibit TCRs with an increased affinity for self that are shared by activated effector T cells in FOXP3-deficient animals (Hsieh et ...between the TCR avidities driving ... See full document
174
Expression and regulation of human endogenous retroviruses (HERVs) in developing and mature T cells
... via the induction of Calcium ion ...not the case. We may speculate that the observed differences may be due to tissue-specific effects; ...to the thymus. Moreover, the majority ... See full document
53
Integrating RNA polymerase II dynamics with alternative polyadenylation
... process in mRNA maturation is the precise removal of noncoding sequences (introns) and the joining of the remaining sequences (exons) in a multistep reaction, a process ... See full document
77
Regulation of alternative splicing of the small GTPase Rac1
... activated in response to extracellular ...binding of Wnt glycoproteins to their receptor, which triggers a signal transduction cascade that stabilizes cytoplasmic "-catenin protein allowing it to ... See full document
166
The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection
... In the bovine model, Brucella-primed pe- ripheral blood mononuclear cells (PBMC) showed an elevation of transcripts for IFN- γ but not for IL-2 or IL-4 when compared to PBMC from naive animals ... See full document
8
Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.
... expression of CD94 and NKG2D were assessed by flow cytometry 24 and 48 hr post ...transfection. The percentage of NKG2D and CD94 expression is given as a comparison between the non-transfected ... See full document
14
Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb.
... placed in either the EPL or GCL within a 200–300 m m distance from the cell body of the MCs to stimulate distal or proximal excitatory inputs, respectively ...activate the two ... See full document
14
The consensus sequence of FAMLF alternative splice variants is overexpressed in undifferentiated hematopoietic cells
... at the 5’ untranslated region (UTR) of ...role in the regulation of hematopoietic cell ...that the 5’-UTR of the platelet-derived growth factor B gene ... See full document
7
The repertoire and specificity of follicular regulatory T cells
... divided in two main groups: cytotoxic ILCs and non-cytotoxic ILCs. The first comprises the long known natural killer (NK) cells, while the second is composed by group 1, 2, and 3 ... See full document
196
Elimination of self-reactive T cells in the thymus: a timeline for negative selection.
... induction of the pro- apoptotic protein Bim [44]. Thus, the lag period between peptide addition and thymocyte death that we observe could reflect the need to accumulate Bim to levels ... See full document
14
Regulation of Oikopleura dioica's alternative cell cycle modes
... states of H3K79 accumulate during a cell’s life cycle, one prediction of the model is that cell-cycle length can affect the average pattern of methylation throughout the cell ... See full document
91
To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.
... required in immune responses [13–18,36]. It is reported that in hepatocytes, holo-RBP triggers STRA6, leading to the activation of JAK2/STAT5 signaling pathway, which is also essential ... See full document
13
The role of NRARP in the regulation of Wnt signaling pathway in T-cell acute lymphoblastic leukemia
... analyze the role of Wnt signaling in T-ALL in a functional fashion, we performed proliferation and viability assays with T-ALL cells overexpressing NRARP in ... See full document
53
Alternative polyadenylation of Rho GTPases : a gene/cell specific process
... APA of Rac1 Rho GTPase was analyzed in cortical neurons, we observed that Rac1 3’UTR undergoes a complete lengthening through the usage of the distal pAs during axonal ...is in ... See full document
106
Regulation of alternative polyadenylation in Drosophila melanogaster
... is the possibility of a protein complex assembling on this cis element and modulating its function, hence polo ...is the case of the COX-2 [256] and prothrombin F2 genes [236], for ... See full document
171
THE ROLE OF ANTIGEN PRESENTING CELLS IN IMMUNE REGULATION MEDIATED BY REGULATORY T CELLS
... injection of 50 mg/kg ketamine, 10 mg/kg xylazine, and 4 mg/kg acepromazine, and the PLN was prepared microsurgically for intravital microscopy as described previously ...(2). The prepared LN was im- ... See full document
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