[PDF] Top 20 Determinants of cell-to-cell variability in protein kinase signaling.
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Determinants of cell-to-cell variability in protein kinase signaling.
... fluctuations in signaling protein concentrations give rise to cell-to-cell variability in protein kinase signaling using analytical ... See full document
17
Heparan sulfate proteoglycans: structure, protein interactions and cell signaling
... amounts of 2-O-sulfate in the IdoA res- idues (Feyzi et ...2-O-sulfate in the IdoA and N- sulfation of the GlcN are required (Crown et ...interaction of heparan sulfate with FGF-4 ... See full document
21
Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death
... Both protein tyrosine kinase inhibitors used in the pres- ent study were able to modify kainate-induced epileptiform ...spreading of the epileptiform activity to the ... See full document
8
Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- and Rho kinase-dependent manner
... (Cell Signaling Technology, USA) was employed to measure phospho-IκB-α, total nuclear factor-kappa B (NF-κB), phospho-NF-κB, phospho-Jun N-terminal kinase (JNK), phospho-p38, and phospho- ... See full document
8
A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells
... culture of Pestalotiopsis photiniae isolated from the Chinese Podocarpaceae plant Podocarpus ...proliferation of HeLa tumor cell ...observed in DAPI-stained HeLa cells. Flow cytometry showed ... See full document
7
Rev. Bras. Reumatol. vol.52 número2 en v52n2a09
... 66% of the patients with rheumatoid arthritis (RA) have signifi cant loss of cell mass (rheumatoid cachexia), mainly of skeletal muscle (rheumatoid ...reduction in muscle strength, ... See full document
8
Integration of AI-2 Based Cell-Cell Signaling with Metabolic Cues in Escherichia coli.
... bacterial signaling systems that facili- tate adaptation in a rapidly changing environment ...consists of a sensor kinase that senses and transmits external signals to its cognate ... See full document
19
Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1Th2 Th17 cytokine balance in neonatal asthmatic mice
... cyclin-dependent kinase inhibitor, was down- regulated (Figure ...levels of PTEN and p27kip1, while downregulating the levels of Akt, GSK-3b, and their phosphorylated forms (Figures 8 and ... See full document
13
A Nonlinear Mixed Effects Approach for Modeling the Cell-To-Cell Variability of Mig1 Dynamics in Yeast.
... aspect of Mig1 dynamics, namely the tran- sient exit and subsequent nuclear re-entry of this protein in response to a shift from high to in- termediate concentrations ... See full document
32
Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.
... applied to a 18 cm nonlinear pH 3–10 IPG strip (GE Healthcare) settled in the slot of a strip holder (BioRad) and rehydrated at 50 V for 16 ...focusing in a Protean IEF Cell (BioRad, ... See full document
15
CFTR trafficking and membrane anchoring: the role of cAMP signalling
... used to be ...was. In an interesting analogy, biologists in the 90s thought of protein kinase A (PKA) as the only link between the second messenger cAMP and CFTR (first reported ... See full document
116
The role of stress-activated protein kinase signaling in renal pathophysiology
... JNK signaling pathway also shows dramatic acti- vation in tubular epithelial cells and myofibroblasts in the obstructed kidney ...Administration of a JNK inhibitor was effective in ... See full document
9
Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
... involved in hematopoiesis. In lymphoid cell lines, T cells and NK human lymphocytes, IRS1 and IRS2 are phosphorylated on tyrosine sites upon stimulation by IL2, IL4, IL7 and IL15 ...phosphorylation ... See full document
11
Recent advances in angiotensin II signaling
... phosphorylation of the STAT proteins p91/84 (STAT1a/ß), p113 (STAT2) and p92 (STAT3), which are transcription ...translocation of STAT1 require JAK2 and p59 Fyn kinase (a member of the Src ... See full document
15
Arq Bras Endocrinol Metab vol.48 número5
... involved in the protein kinase A (PKA) ...mediator of cAMP signaling in mammals ...serine-threonine kinase and under hormone stimuli it promotes phosphorylation and plays ... See full document
5
The Aspergillus fumigatus pkcA G579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model.
... resulted in restricted vegetative ...growth. In A. fumigatus, the downstream components of the CWI, (mpkA, bck1 and mkk2) and some upstream mechano- sensors such as midA also play a role in ... See full document
34
NCAM1 Polysialylation
... function of the cellular prion protein (PrP C ...knowledge of its function will shed light on its contribution to neurodegenerative diseases and suggest ways to interfere with the ... See full document
25
Expanding the substantial interactome of NEMO using protein microarrays.
... regulator of a host of cellular responses to extracellular and intracellular ...adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals ... See full document
10
Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
... is to understand the mechanisms responsible for chemical regu- lation of gap ...involved in the closure of Cx43 by low intracellular pH ...eral protein kinases are activated under con- ... See full document
8
Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.
... absence of Shh ligand, Ptc1 functions to inhibit the pathway by suppressing the activity of the transmembrane protein Smoothened (Smo) ...Smo to initiate signaling [24,47,48] ... See full document
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