[PDF] Top 20 Redox regulation of insulin degradation by insulin-degrading enzyme.
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Redox regulation of insulin degradation by insulin-degrading enzyme.
... ability of GSH to reduce the disulfides in partially degraded insulin as confirmed by HPLC analysis of the products (Figure ...Intact insulin is not affected by GSH. Thus, the ... See full document
8
Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
... secreted by microglia involved in Ab degradation, even though the molecular basis of IDE regulation are poorly known ...effect by promoting Ab ...followed by an increase ... See full document
8
Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme.
... regions of the brain is associated with selective ...decreased insulin- degrading enzyme (IDE) levels in the cerebrum and accelerated phenotypic features of AD when crossbred with ... See full document
14
Degradation of pheromone and plant volatile components by a same odorant-degrading enzyme in the cotton leafworm, Spodoptera littoralis.
... and regulation in males are consistent with a possible function of this enzyme as a ...that of ApolPDE [10] and other olfactory genes, such as Pheromone-Binding ...levels of SlCXE7 ... See full document
7
Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Kruppel-like factor 15.
... family of CTRPs, which are conserved adiponectin paralogs ...stream by obesity [17,18,23]. Likewise, treatment of adipocytes with TNFa leads to reduction of adiponectin and adipolin ...levels ... See full document
7
Use of a small peptide fragment as an inhibitor of insulin fibrillation process: a study by high and low resolution spectroscopy.
... with insulin fibrillation by various biophysical methods. Insulin undergoes conformational changes under certain stress conditions leading to amyloid ...Fibrillation of insulin poses a ... See full document
15
Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.
... part of the variation in plasma insulin than a single locus ...models of various degrees of complexity could explain the joint regulation of a common trait by multiple ... See full document
12
Responsiveness of glycogen breakdown to cyclic AMP in perfused liver from rats with insulin-induced hypoglycemia
... from insulin and con- trol rats were perfused for 20 min (10-30 min) with cAMP or DB-cAMP dissolved in the perfusion fluid followed by a post-infu- sion period (20 min) to allow a return to basal ... See full document
7
Insulin autoimmune syndrome in an occidental woman: a case report and literature review
... serum insulin, and C-peptide levels were 91 mg/dL (reference range: 65 – 99 mg/dL), ...hours of fasting, hyperinsulinemic hypoglycemia was observed with high levels of anti-insulin antibodies ... See full document
5
Indices of insulin resistance in paediatric obesity
... gender), children with other endocrine disorders such as hypothyroidism, Cushing’s syndrome, type 1 diabetes mellitus, obesity syndromes, renal and liver diseases, active infection, those on medication and those who were ... See full document
7
Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients
... they underwent the hyperglycemic clamp study as described (10). Briefly, each volun- teer came to the laboratory at 7:00 am after an overnight fast. A cannula was retrogradely inserted into a peripheral hand vein and ... See full document
8
Expression of the human glucokinase gene: important roles of the 5' flanking and intron 1 sequences.
... kb of liver-specific exon 5 9 flanking sequence and intron 1 sequences are conserved among mammals, and DNase I hypersensitive sites have been mapped to both of these regions [7,21,22] we tested the ability ... See full document
13
Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats
... enhanced insulin sensitivity, IRS-1, and Akt phosphorylation while it reduced PTP-1B levels in gastrocnemius muscle compared to nontreated obese ...program of nutritional reeducation, GbE therapy might be ... See full document
9
Purification of bovine pancreatic glucagon as a by-product of insulin production
... a by-product of insulin production is ...crystallization of insulin was precipitated using ammonium sulfate and isoelectric ...purified by ion-exchange chro- matography on ... See full document
6
Non-obese adult onset diabetes with oral hypoglycemic agent failure: islet cell autoantibodies or reversible beta cell refractoriness?
... quency of ICA-positive patients aged 35-75 years at ...study of young adult diabetic patients, Hagopian et ...third of them probably corresponded to latent autoimmune diabetes of the adult, ... See full document
9
Temporal relationship between diet-induced steatosis and onset of insulin/leptin resistance in male Wistar rats.
... addition of pro- tease inhibitor (Roche, Nutley, USA) and phosphatase inhibitor cocktail (Roche, Nutley, ...μg of protein were fractionated by SDS-PAGE (8–12% gradient gel), transferred onto a PVDF ... See full document
15
Duodenal-jejunal bypass normalizes pancreatic islet proliferation rate and function but not hepatic steatosis in hypothalamic obese rats
... presence of a severe insulin ...supported by hyperinsulinemia, provided by insulin hypersecretion from the pancreatic ...disruption of the autonomic nervous system (ANS) in HyO ... See full document
11
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
... levels of glucose also cause oxidative stress, leading to activation of c-Jun N-terminal protein kinase ...the insulin Figure 2. Overexpression of IRE1a correlates with reduced Insulin ... See full document
7
Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition andMetabolism (ISRNM)
... effect of low insulin on muscle is clear: Uncon- trolled type 1 diabetes mellitus leads to negative nitrogen balance, lean tissue atrophy, and hyperaminoacidemia easily reversed through the provision ... See full document
14
Melatonin as metabolic regulator of sertoli cells
... and regulation of spermatogenesis (for review (Petersen, ...development of the testes such as in the formation of the seminiferous cords and thus, in the expression of the male ... See full document
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