[PDF] Top 20 The role of the kinetochore in chromosome signaling and segregation.
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The role of the kinetochore in chromosome signaling and segregation.
... identification of novel centromere-kinetochore associated proteins involved the use of monoclonal antibodies against human mitotic chromosome scaffolds (Compton et ...One of ... See full document
169
Role of Wnt signaling in heart disease
... In the presence of a stress situation the heart triggers cardioprotective responses, which enable the heart to pump enough blood to meet the metabolic demands of ... See full document
116
Evolution of the TGF-β signaling pathway and its potential role in the ctenophore, Mnemiopsis leidyi.
... to the sponge, Amphimedon, the Mnemiopsis genome does not contain any of the known diffusible antagonists (Figure ...Amphimedon and Mnemiopsis possess Tolloid orthologues, the ... See full document
15
The role of stress-activated protein kinase signaling in renal pathophysiology
... Blockade of p38 signaling has also been directly impli- cated in preventing podocyte damage and associated ...vation in podocytes was evident just prior to the onset of ... See full document
9
When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.
... generators of aneuploidy in cell populations ...telophase, the potential of MMs to generate aneuploidy and clonal evolution in neoplastic tissue depends on the ... See full document
13
Review of the Y chromosome and hypertension
... that the rat liver, like the mouse liver, is androgenized at an early stage and the hepatic angiotensinogen system might play a key role in the cascade of events ... See full document
13
The Role of Complex Chromosome Translocations in Leukemia Luís Miguel Ramos Vieira
... for the MLL-MLLT3 and MLL-MLLT1 fusions, ...expression of either fusion protein could promote leukemogenesis in ...that the latent period for leukemia onset is relatively long (Lavau et ... See full document
166
The involvement of the protein Mast in microtubule dynamics and kinetochore-microtubule interactions
... yeast kinetochore binds just one microtubule, ...eleven and vertebrate kinetochores typically bind fifteen to thirty microtubules (Maiato et ...Maiato and Sunkel, 2004). In yeast, a unit ... See full document
192
The role of the SLAMSAP signaling pathway in the modulation of CD4+ T cell responses
... by the equilibrium of signals received by a large number of cell surface receptors, among them the activa- tion receptors, co-stimulatory molecules and inhibitory molecules ...Binding ... See full document
8
Role of the nodal signaling pathway in left-right morphogenesis of the zebrafish (Danio rerio) heart
... analyses of cell movements, shapes, and rear- rangements during this process in wild type (Horne-Badovinac et ...For in- stance, cell shape analyses in the am- niote dorsal ... See full document
176
Exploring the role of pro-inflammatory signaling in myelin repair
... Dysregulation of immune responses in the central nervous system (CNS) is thought to underlie the development of several neurological ...is the most common autoimmune disease ... See full document
120
A role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axis.
... cell-cell and cell-extracellular matrix attachments. Integrins are signaling receptors because their cytoplasmic tails are docking sites for cytoskeletal and signaling ...family of band ... See full document
9
Modulating the bone marrow microenvironment:the role of DLL4:Notch signaling and hypoxia
... abrogate the interaction between malignant HSCs and BM niches, by blocking their physical binding or the growth factors secreted by the ...before, the chemokine axis SDF- 1/CXCR4 is ... See full document
184
The role of NRARP in the regulation of Wnt signaling pathway in T-cell acute lymphoblastic leukemia
... µg of protein) were diluted in laemmli buffer and lysis buffer and boiled for 5 minutes in a dry bath to promote protein ...down and loaded on a SDS-PAGE gel with different ... See full document
53
Kinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggs.
... presence of kinetochores and their proper attachment to microtubules to establish a biorientation configuration may provide a more advanced structure to ensure accurate chromo- some segregation while ... See full document
9
Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast.
... levels of crossovers at both 23 and 33 uC, with a more severe defect at 33uC ...msh4 and msh5 mutants showed improved gamete viability at 33uC (Figure 1A and ...not the case for ... See full document
6
Study of the role of RAF-1 in MAPK signaling in thyroid cancer cells
... assess the effect of PD98059 on cell growth, Sulforhodamine B (SRB) protein staining assay was ...Skehan and colleagues (Skehan, Storeng et ...cytotoxicity and cell proliferation for ... See full document
129
The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes
... By the 1950s, most of the basic actions of the estrogenic hormones were recognized, such as their stimulation on the growth and function of tissues of ... See full document
5
Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle.
... LUC and the Renilla luciferase reporter plasmids, were treated with tumor necrosis factor (TNFa) for 20 ...NFkB and promotes its relocalization from the cytoplasm to the ...used ... See full document
16
The role of OsRMC gene in the JA signaling pathway: a transgenic approach in Arabidopsis and by Y1H assay
... as signaling molecules. These signaling molecules share notable structural and functional properties with prostaglandins found in ...acid and function in normal developmental ... See full document
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