efflux pumps
Transcriptional Analysis of MexAB-OprM Efflux Pumps System of Pseudomonas aeruginosa and Its Role in Carbapenem Resistance in a Tertiary Referral Hospital in India.
... of efflux pumps in conferring meropenem resistance and effect of single dose exposure of merope- nem on transcription level of mexA gene in clinical isolates of ...possess efflux pump activity ...
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Efflux pumps expression and its association with porin down-regulation and beta-lactamase production among Pseudomonas aeruginosa causing bloodstream infections in Brazil
... of efflux systems generally confers modest levels of antimicrobial resistance ...of efflux pumps and/or porin loss may lead to high level and/or co-resistance phenotypes ...reason, efflux ...
7
Membrane fusion proteins of type I secretion system and tripartite efflux pumps share a binding motif for TolC in gram-negative bacteria.
... tripartite efflux pumps, although the debate continues ...drug efflux pumps with a modified a-hairpin domain, such that HlyD makes a direct contact with TolC through a structural motif similar ...
7
Activity of compounds isolated from Carpobrotus edulis on efflux pumps of bacteria and cancer cells
... superfamily efflux antibiotics such as, erythromycin, nalidixic acid, tetracycline, sulfamides, fluoroquinolones, rifampicin or chloramphenicol, and catalyse uniport, solute/cation (H + or Na + ) symport, solute/H ...
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Adaptive resistance in bacteria requires epigenetic inheritance, genetic noise, and cost of efflux pumps.
... of efflux pumps are associated with an energetic cost that must be taken into ...the pumps are very unspecific on its substrates [21, 32, ...acrAB-tolC efflux pump, is known to recognize a ...
18
Hyper Accumulation of Arsenic in Mutants of Ochrobactrum tritici Silenced for Arsenite Efflux Pumps.
... reduced efflux of ...metal efflux proteins resulted in strains with enhanced metal bioaccumulation ability, which could be seen as a useful tool to include in a bioremediation strategy ...nic efflux ...
14
Efflux in fungi: la piece de resistance.
... Efflux pumps in secondary metabolite gene clusters that are responsible for synthesis of mycotoxins are less well ...of efflux pumps in secondary metabolite clusters have been constructed, and ...
7
Rev. bras. farmacogn. vol.21 número5
... multidrug efflux pumps belonging to the ATP-binding cassette transporters ...of efflux pumps belonging to the pleiotropic drug resistance (PDR) family of ABC ...these efflux ...
7
The role of the efflux mechanisms in multidrug resistance in Mycobacterium tuberculosis
... combat efflux mediated resistance involve the modification of antibiotics into derivatives that are minimally affected by efflux and the development of therapeutic agents that inhibit the efflux ...
258
Determination of real-time efflux phenotypes in Escherichia coli AcrB binding pocket phenylalanine mutants using a 1,2'-dinaphthylamine efflux assay.
... RND efflux pumps in whole cells, a limitation of these dyes has to be considered: their hydrophobicity limits the application to relatively low ...real-time efflux assay, since they would probably ...
5
ABC Efflux Transporters and the Circuitry of miRNAs
... keep efflux pumps inhibited, cells were then resuspended in 500 µL of fresh medium in the presence or absence (control cells) of VP, and incubated for another hour at 37 ◦ ...
17
Efflux pump activity in drug resistance of Staphylococcus aureus
... that efflux is an important player in resistance to antibiotics, with a proven clinical impact for several bacterial species, mainly Gram-negative bacteria, has lead to the development of strategies to overcome ...
292
Genotypic and phenotypic detection of efflux pump in Rhodococcus equi
... is present in a comparable proportion of isolates recovered from all three sources. We suppose that the presence of the req_39680 gene is not an adaptation to the host but may be just as relevant to its saprophytic ...
5
A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.
... Bacterial efflux pumps are active transport proteins responsible for resistance to selected biocides and ...of efflux pumps is up-regulated in a number of highly pathogenic bacteria, including ...
12
Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium
... tuberculosis efflux systems (Viveiros et ...other efflux inhibitors (Ordway et ...of efflux inhibitors in combination with antibiotics may constitute an important alternative as adjuvants of the ...
18
Síntese de nano-veículos poliméricos para entrega de fármacos com atividade anti-tumoral
... 51 also investigated. The therapeutic effect was indeed improved (IC50 triple drug combination = 13.26 µM) (Figure 27 B). In fact, comparing the cytotoxic effect of Crizotinib plus Palbociclib or the same combination ...
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Mutational and acquired carbapenem resistance mechanisms in multidrug resistant Pseudomonas aeruginosa clinical isolates from Recife, Brazil
... for efflux pumps and AmpC cephalosporinase were assessed by quantitative ...of efflux pumps and β-lactamase production were responsible for the multidrug resistance in the isolates ...
7
Metallo-β-lactamase-production in meropenem-susceptible Pseudomonas aeruginosa isolates: risk for silent spread
... The carbapenems represent important therapeutic options for serious infections caused by Pseudomonas aeruginosa. However, P. aeruginosa that are resistant to these antimicrobials have emerged and spread within hospital ...
5
Synergistic effects of amiodarone and fluconazole on Candida tropicalis resistant to fluconazole
... (47) have reported that the treatment of azole-resistant strains of Saccharomyces cerevisiae with amiodarone decreased multidrug resistance due to the inhibition of cellular efflux pumps[r] ...
10
Soil CO2 Efflux in Agroforestry and Full-Sun Coffee Systems
... At each farm, we selected a coffee field of approximately 300 m 2 . In field, we selected 20 sampling points with 1-m 2 each, which were located between the rows of coffee plant. Among the 20 points, 10 points were ...
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