[PDF] Top 20 Arq Bras Endocrinol Metab vol.50 número4

... O N BEH ALF O F TH E B RAZILIAN Society of Endocrinology and Metabo- lism and its D epartment of Bone and Mineral Research and the Brazilian Society for Bone and Mineral Research, we are[r] ... See full document

... (33,34). In women with pre-existing vertebral frac- tures, alendronate therapy reduced the incidence of vertebral, hip and wrist fractures by about 50% (table 2), and the risk of multiple vertebral fractures was ... See full document

... Osteoporose é uma doença esquelética caracterizada pelo compro- metimento da força óssea que predispõe ao aumento do risco de fratu- ra na pessoa. As fraturas são sempre relacionadas com aumento da morbidade, alta ... See full document

... U sing meta-analyses of population-based cohorts from Europe, North America, Asia, and Australia, the international validity of candidate risk factors for frac- ture was examined by a WH O task force at a conference held ... See full document

... Combination therapy of teriparatide (recombi- nant human parathyroid hormone 1–34), an anabolic agent, and HT has also been studied. Women who had been on HT for at least two years were randomized to either remain on HT ... See full document

... Hormone receptors and, specifically, estrogen receptors were described about four decades ago. For estrogens, there are two receptors, estro- gen receptor alpha (ERα) and estrogen receptor β (ERβ). The two recep- tors ... See full document

... Os agentes anti-reabsortivos são as drogas mais usadas no tratamento da osteoporose, porém os anabólicos recentemente ampliaram nossas opções terapêuticas. Por estimular diretamente a formação, os agentes anabólicos ... See full document

... (Arq Bras Endocrinol Metab 2006;50/4:685-693) Descritores: Cálcio; Osteoporose; Fratura; Cálculo renal; Câncer colôni- co; Hipertensão; Obesidade; Resistência ... See full document

... F O R ABO U T 70 YEARS , H arvey Cushing described the syndrome of hypercortisolism and the associat- ed bone loss (1932). In 1954 the effects of exogenous glucocorticoids on bone were recognized. The Cush- ing syndrome ... See full document

... Doença de Paget óssea é uma desordem focal da remodelação óssea, inicialmente acompanhada de um aumento da reabsorção óssea, seguida de desorganizada e excessiva formação óssea, levando a dor, deformidades e fraturas. ... See full document

... gene localizado no cromossomo X que codifica uma enzima proteolítica Zn-metaloendopeptidase regu- ladora do fosfato (PHEX), implicada na regulação do FGF-23, já foram identificadas, e sua partici- pação reconhecida na ... See full document

... Nas últimas décadas houve um grande aumento no número de trans- plantes realizados no Brasil e no mundo, o que proporcionou uma me- lhora na sobrevida e qualidade de vida dos pacientes transplantados. A osteoporose e o ... See full document

... disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture” (1). Approximately 40–50% of women sustain ... See full document

... of cellular functions such as increased cell prolifera- tion in fibroblasts (39), induction of cell differentia- tion in keratinocytes (49) and human colon epithe- lial cells (50), prevention of apoptosis in AT-3 ... See full document

... The degree of suppression of bone turnover induced by anti-resorptive drugs varies, whether measured by biochemical markers or bone histomorphometry. The most potent effects are seen with alendronate, zole- dronate and ... See full document

... The diagnosis of osteoporosis and monitoring of treatment is a challenge for physicians due to the large number of available tests and complexi- ties of interpretation. Bone mineral density (BMD) testing is a ... See full document

... Tecnologias para medidas de densidade (DMO) e outros parâmetros determinantes da resistência óssea no esqueleto periférico vêm sendo estu- dados desde os anos 60. Absorciometria Fotônica de Energia Única (SPA), ... See full document

... decade and in healthy men, levels of practically all markers remain more or less unchanged until 70 years of age. After that, a slight increase is usually seen in both formation and resorption markers (4-7). In con- ... See full document

... Regular sunlight exposure has been considered an effec- tive prophylaxis against vitamin D deficiency (12). However, studies in other regions of the world located at low latitude, such as the Middle East, have also shown ... See full document

... Do Hiperparatiroidismo Primário Leve ao Severo: A Experiência Brasileira. Na maioria dos relatos da literatura recente, o hiperparatiroidismo primário apresenta-se, com freqüência, na forma assintomática. Em nossa ... See full document