[PDF] Top 20 The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity
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The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity
... vitro and in vivo and with worsening of HD clinical features (DiFiglia et ...Li and Li, ...inclusions and disease progression. The formation of large inclusions was ... See full document
72
Alpha-synuclein phosphorylation role on Parkinson's disease
... been the center of focus in understanding the etiology of a group of overlapping neurodegenerative disorders, including PD, which are pathologically characterized by the ... See full document
128
Stress-induced phosphorylation of c-Jun-N-terminal kinases and nuclear translocation of Hsp70 in the Wistar rat hippocampus
... critical role in learn� ing and memory (eichenbaum� 200�)� it is possible that the �N� signaling pathway may also be involved in the formation of emotional memory� which is ... See full document
8
Normal aging modulates the neurotoxicity of mutant huntingtin.
... a role in neurodegenerative ...expansion of a polyglutamine tract in the protein huntingtin (Htt), the role of aging is ...length, the probability of disease ... See full document
13
Hypericum perforatum phenolic compounds : protective role in the toxicity induced by heterologous expression of α-synuclein and huntingtin in yeast cells
... family of dominantly inherited neurodegenerative disorders characterized by degeneration of neurons in the striatum and, to a lesser extent, in the cerebral cortex (Sorolla et ...age ... See full document
64
ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms
... in the formation and regulation of multimeric protein complexes within the nucleus ...interactions of the mutant ATXN1, is also a hallmark of the SCA1 disease ... See full document
14
The role of alpha-synuclein phosphorylation in synucleinopathies
... a role in aSyn pathobiology: missense mutations and genomic multiplications of SNCA (the gene encoding aSyn), oxidative stress and C-terminal ...have the capacity ... See full document
134
Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues.
... reduces toxicity and aggregation; together demonstrating crucial importance of ...kinetics. Of note, we also find aggregates in A42R, while this variant shows rather mild phenotype in ... See full document
24
Alpha-synuclein phosphorylation role on Parkinson’s disease
... In the present work, we also studied the role of S129 phosphorylation on aSyn aggregation and ...mimic the unphosphorylated form of S129, since ... See full document
52
Modulation of α-synuclein aggregation and toxicity
... in the surviving neurons of Parkinsons’s disease patients and other synucleinopathy ...This aggregation process is greatly affected by different post-translational modifications, such as ... See full document
60
Deciphering the role of Yap4 phosphorylation under stress conditions
... many of which contain phosphorylation sites, are important key-players in this ...level of control by kinases either activating or repressing a given ...is the effector kinase of ... See full document
268
Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding.
... in the AR splice variants expressed in tumor cells that are sim- ilar in structure to the truncated AR used in this ...a role in progression to castrate resistance and acquired resistance to ... See full document
19
Dissecting the role of alpha-synuclein phosphorylation in Parkinson’s disease
... families of E3 ligases have been identified until now, namely the Really Interesting New Gene (RING) and the Homologous to the E6-AP Carboxyl Terminus type (HECT), which differ only in ... See full document
87
Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression.
... by the inheritance of one mutant copy of the huntingtin ...Mutant huntingtin protein (mHtt) contains an expanded polyglutamine repeat region near the ...Cleavage of ... See full document
12
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
... tors of the structural and functional properties of proteins in health and pathological ...lines of evidence suggest that phosphorylation of ASYN may play an ... See full document
18
The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease.
... included the following: mouse anti-myc (Roche), mouse anti-HA (Roche), mouse anti-human a-syn phospho (Ser129) (anti-pS129a- syn) (Wako Chemicals), mouse anti-a-syn (BD Transduction Laboratories), mouse anti-human ... See full document
14
THE ROLE OF GLIPTINS ON ADIPOGENESIS
... ubiquitous and multifunctional molecule that exists in both soluble and membrane bound ...acids and an extracellular domain with 738-amino acids [56] . When the hydrophobic ... See full document
87
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.
... IKK2 oligomerization hypothesis helps explain the difficulty researchers have experienced in identifying a single upstream IKK2 kinase responsible for activating IKK2 by phosphorylating its activation loop ... See full document
13
Radical mechanisms of methyl vinyl ketone oligomerization through aqueous phase OH-oxidation: on the paradoxical role of dissolved molecular oxygen
... Hallquist, M., Wenger, J. C., Baltensperger, U., Rudich, Y., Simpson, D., Claeys, M., Dom- men, J., Donahue, N. M., George, C., Goldstein, A. H., Hamilton, J. F., Herrmann, H., Hoff- mann, T., Iinuma, Y., Jang, ... See full document
42
Molecular insights into the role of alfa-synuclein phosphorylation in synucleinopathies
... misfold and aggregate, forming beta-sheet structures (Weinreb et ...toxic, and some authors still claim that the final mature aggregates are the most dangerous for cell homeostasis (El-Agnaf ... See full document
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