[PDF] Top 20 Structural Characterization of Serine Protease Complexes with Novel Inhibitors
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Structural Characterization of Serine Protease Complexes with Novel Inhibitors
... Because of its difficult purification and crystallization processes, it is usual to use Porcine Pancreatic Elastase (PPE) as a model protein for ...a serine protease with 240 amino acids that ... See full document
82
Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease.
... PMSF serine protease inhibitors (Fig. 8). Both inhibitors did not affect growth of ...attenuation of F. nucleatum by both serine-protease inhibitors resulted ... See full document
13
Flow cytometry as a novel tool for structural and functional characterization of isolated yeast vacuoles
... properties of different cellular ...disruption of cells/tissues through homogenization followed by fractionating steps (centrifugations) that separates different organelles by their physical properties, ... See full document
57
Characterization, subsite mapping and N-terminal sequence of miliin, a serine-protease isolated from the latex of Euphorbia milii
... functioning of multicellular ...aspects of the plant life cycle involving a variety of functions, from mobilization of storage pro- teins during seed germination to the initiation of ... See full document
5
Purification and characterization of a serine protease from Alternaria alternata
... type of reaction the IgE binds to high affinity receptors (FcεRI) on mast cells and ...activation of complement by IgG or IgM binding to an antigen on a ...cell with altered ...examples of ... See full document
67
Synthesis, structural and spectroscopic characterization of novel zinc(II) complexes with N-methylsulfonyldithiocarbimato and N-methylsulfonyltrithiocarbimato ligands
... determined with a Mettler FP5 ...absorption with a Hitachi Z-8200 Atomic Absorption ...recorded with a Perkin–Elmer 283 B infrared spectrophotometer using CsI ...recorded with a Bruker Advance ... See full document
6
Characterization, subsite mapping and N-terminal sequence of miliin, a serine-protease isolated from the latex of Euphorbia milii
... functioning of multicellular ...aspects of the plant life cycle involving a variety of functions, from mobilization of storage pro- teins during seed germination to the initiation of ... See full document
5
Identification and characterization of a novel factor XIIa inhibitor in the hematophagous insect, Triatoma infestans (Hemiptera : Reduviidae)
... targets of hematophagous animals. Factor XIIa, a serine protease of the contact phase of blood coagulation, is involved in the inflammation process [12] and is also an important ac- ... See full document
5
Tryptogalinin is a tick Kunitz serine protease inhibitor with a unique intrinsic disorder.
... together with TdPI, another potent human b-tryptase inhibitor from the hard tick Rhipicephalus appendiculatus ...lack of an alpha-helix, shortening of a loop region, differences in disulfide-bridges ... See full document
12
Structural and functional characterization of cleavage and inactivation of human serine protease inhibitors by the bacterial SPATE protease EspPα from enterohemorrhagic E. coli.
... react with target ...consists of a Leu-Ser motif which is also located in the exposed RCL. Cleavage of the non-inhibitory AGT shows that a reactive bond is not strictly required for substrate ... See full document
12
Clinical and Biochemical Evaluation of HIV-Related Lipodystrophy in an Ambulatory Population from the Hospital Universitário Cassiano Antonio de Morais, Vitória, ES, Brazil
... HIV-related lipodistrophy was first described in 1998 [9,10], following a Federal Drug Administration (FDA) warning that anti-retrovirals were associated with hyperglycemia. It is characterized by dorsocervical ... See full document
5
Synthesis and structural characterization of palladium and platinum mono- and bimetallic complexes with ligands containing nitrogen and sulfur.
... spectroscopic characterization of the monometallic complexes shows that the metal centre are coordinated through the N-endocyclic (L=2-aminothiazol; benzothiazol) and through the sulphur when ... See full document
6
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.
... inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic ...treatment with inhibitors and knockdown ... See full document
18
The Place of protease inhibitors in antiretroviral treatment
... 1996, with the introduction of highly active antiretroviral (ARV) therapy (HAART), a number of drugs have been ...transcriptase inhibitors (NNRTI)-based therapies and ritonavir-boosted ... See full document
4
PURIFICATION AND PARTIAL CHARACTERIZATION OF A COAGULANT SERINE PROTEASE FROM THE VENOM OF THE IRANIAN SNAKE Agkistrodon halys
... one of several dangerous snake species in ...stage of purification, 0.82 mg of purified enzyme was obtained from ...venom of the Iranian snake Agkistrodon halys contains about ... See full document
13
Structural bioinformatics study of cyclin-dependent kinases complexed with inhibitors
... method of choice when there is a clear relationship of homology between the sequence of a target pro- tein and at least one known ...structures of two proteins will be simi- lar if their ... See full document
9
Perspectives of digestive pest control with proteinase inhibitors that mainly affect the trypsin-like activity of Anticarsia gemmatalis Hübner (Lepidoptera: Noctuidae)
... agree with those reported by Oliveira et ...sensitivity of the proteolytic activity of the partially purified fraction to BZD than to ...absence of important effects of other compounds ... See full document
9
José Andrés Morgado-Díaz+ , Raquel Elisa da Silva-Lopez, Carlos Roberto Alves, Maurilio José Soares, Suzana Corte-Real, Salvatore Giovanni De Simone
... distribution of serine protease in ...fraction. Protease activity was also recovered in the crude plasma membrane fraction, but in minor amounts, indicating that the enzyme may, in some way, ... See full document
8
J. Braz. Chem. Soc. vol.21 número1
... aspartic protease inhibitors, conjugates of ferrocene with statine were designed and synthesized by coupling reaction using the standard N,N’-dicyclohexylcarbodiimide (DCC) and ... See full document
8
Microwave synthesis, spectral, thermal, and antimicrobial activities of some transition metal complexes involving 5-bromosalicylaldehyde moiety
... course of microwave assisted synthesis, it was observed that the reaction time decreased from hours to minutes and availability of the product with better yield as compared to the conventional ...Use ... See full document
12
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